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ES459230A1 - PROCEDURE FOR THE PREPARATION OF NEW 17BETA-ESTERS OF TESTOSTERONE AND 5ALFA-DIHYDROTESTOSTERONE. - Google Patents

PROCEDURE FOR THE PREPARATION OF NEW 17BETA-ESTERS OF TESTOSTERONE AND 5ALFA-DIHYDROTESTOSTERONE.

Info

Publication number
ES459230A1
ES459230A1 ES459230A ES459230A ES459230A1 ES 459230 A1 ES459230 A1 ES 459230A1 ES 459230 A ES459230 A ES 459230A ES 459230 A ES459230 A ES 459230A ES 459230 A1 ES459230 A1 ES 459230A1
Authority
ES
Spain
Prior art keywords
dihydrotestosterone
testosterone
esters
preparation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES459230A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/691,103 external-priority patent/US4098802A/en
Application filed by Akzo NV filed Critical Akzo NV
Publication of ES459230A1 publication Critical patent/ES459230A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0025—Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento para la preparación de nuevos 17 beta-ésteres de testoterona y 5 alfa-dihidrotestosterona, caracterizado porque el alcohol esteroide es hecho reaccionar con un ácido monocarboxílico alifático que tiene 8-16 átomos de carbono o un derivado funcional del mismo, teniendo dicho ácido la fórmula en la que n=0 ó 1; R1=alcohilo (1-5); y R2=alcohilo (3-10 C), con la condición de que R2 no es alcohilo (3-6 C), cuando R1=alcohilo (1-2 C), *** Ver imagenProcess for the preparation of new 17 beta-esters of testosterone and 5 alpha-dihydrotestosterone, characterized in that the steroid alcohol is reacted with an aliphatic monocarboxylic acid having 8-16 carbon atoms or a functional derivative thereof, said acid having the formula where n=0 or 1; R1=alkyl (1-5); and R2=alkyl (3-10 C), with the proviso that R2 is not alkyl (3-6 C), when R1=alkyl (1-2 C), *** See image

ES459230A 1976-05-28 1977-05-27 PROCEDURE FOR THE PREPARATION OF NEW 17BETA-ESTERS OF TESTOSTERONE AND 5ALFA-DIHYDROTESTOSTERONE. Expired ES459230A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/691,103 US4098802A (en) 1975-02-18 1976-05-28 Oral pharmaceutical preparation having androgenic activity

Publications (1)

Publication Number Publication Date
ES459230A1 true ES459230A1 (en) 1978-11-16

Family

ID=24775172

Family Applications (1)

Application Number Title Priority Date Filing Date
ES459230A Expired ES459230A1 (en) 1976-05-28 1977-05-27 PROCEDURE FOR THE PREPARATION OF NEW 17BETA-ESTERS OF TESTOSTERONE AND 5ALFA-DIHYDROTESTOSTERONE.

Country Status (12)

Country Link
JP (1) JPS52148060A (en)
AR (1) AR214323A1 (en)
BE (1) BE855163A (en)
CH (1) CH627761A5 (en)
DE (1) DE2723876C2 (en)
DK (1) DK146096C (en)
ES (1) ES459230A1 (en)
FI (1) FI57597C (en)
FR (1) FR2352832A1 (en)
GB (1) GB1567515A (en)
NL (1) NL7705790A (en)
SE (1) SE425493B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001291775B2 (en) * 2000-08-23 2005-09-08 N.V. Organon Testosterone ester formulation for human use
JO2505B1 (en) 2003-03-14 2009-10-05 باير شيرنغ فارما اكتنجيسيلشافت method and pharmaceutical compositions for reliable achievements of acceptable serum testosterone levels
GB0807605D0 (en) * 2008-04-28 2008-06-04 Diurnal Ltd Lipid composition
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
TW201521731A (en) * 2013-03-15 2015-06-16 利波辛股份有限公司 Lipobalanced long chain testosterone esters for oral delivery
WO2016205423A2 (en) 2015-06-15 2016-12-22 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy
US12150945B2 (en) 2018-07-20 2024-11-26 Lipocine Inc. Liver disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189235C (en) * 1974-02-28 1993-02-16 Akzo Nv METHOD FOR THE PREPARATION OF AN ORAL PHARMACEUTICAL PREPARATION WITH ANDROGENIC ACTION

Also Published As

Publication number Publication date
FR2352832A1 (en) 1977-12-23
FI57597B (en) 1980-05-30
DK236877A (en) 1977-11-29
JPS52148060A (en) 1977-12-08
FI57597C (en) 1980-09-10
DE2723876C2 (en) 1986-10-30
AR214323A1 (en) 1979-05-31
SE425493B (en) 1982-10-04
DK146096C (en) 1983-11-21
SE7706235L (en) 1977-11-29
JPS6145637B2 (en) 1986-10-08
GB1567515A (en) 1980-05-14
NL7705790A (en) 1977-11-30
CH627761A5 (en) 1982-01-29
FI771684A7 (en) 1977-11-29
BE855163A (en) 1977-11-28
DK146096B (en) 1983-06-27
DE2723876A1 (en) 1977-12-15
FR2352832B1 (en) 1980-07-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103