ES458980A1 - Procedimiento de preparacion de derivados del psoraleno. - Google Patents
Procedimiento de preparacion de derivados del psoraleno.Info
- Publication number
- ES458980A1 ES458980A1 ES458980A ES458980A ES458980A1 ES 458980 A1 ES458980 A1 ES 458980A1 ES 458980 A ES458980 A ES 458980A ES 458980 A ES458980 A ES 458980A ES 458980 A1 ES458980 A1 ES 458980A1
- Authority
- ES
- Spain
- Prior art keywords
- psoralene
- hydroxy
- dermatology
- oxy
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003194 psoralenes Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- BGEBZHIAGXMEMV-UHFFFAOYSA-N 5-methoxypsoralen Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC BGEBZHIAGXMEMV-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 abstract 1
- -1 diethyl-phosphono diethylaminoethyl Chemical group 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910000104 sodium hydride Inorganic materials 0.000 abstract 1
- 239000012312 sodium hydride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Procedimiento de preparación de derivados del psoraleno, particularmente de extracción del metoxi-5 psoraleno o bergapteno de la esencia de bergamota, caracterizado porque consiste en hacer envejecer la esencia de bergamota por almacenado durante varios meses en atmósfera fría por debajo de 0ºC, en obtener así una cera constituida por una mezcla de pasta-aceite, en escurrir dicha cera con una trompa de vacío,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH668876A CH614957A5 (es) | 1976-05-28 | 1976-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES458980A1 true ES458980A1 (es) | 1978-02-16 |
Family
ID=4313469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES458980A Expired ES458980A1 (es) | 1976-05-28 | 1977-05-20 | Procedimiento de preparacion de derivados del psoraleno. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4217445A (es) |
| JP (1) | JPS52145510A (es) |
| AR (1) | AR215634A1 (es) |
| AU (1) | AU516330B2 (es) |
| BE (1) | BE854630A (es) |
| BR (1) | BR7703458A (es) |
| CA (1) | CA1079724A (es) |
| CH (1) | CH614957A5 (es) |
| DE (1) | DE2724207C2 (es) |
| EG (1) | EG13242A (es) |
| ES (1) | ES458980A1 (es) |
| FR (1) | FR2362854A1 (es) |
| GB (1) | GB1579268A (es) |
| IN (1) | IN155951B (es) |
| IT (1) | IT1085806B (es) |
| LU (1) | LU77422A1 (es) |
| NL (1) | NL7705869A (es) |
| SU (2) | SU747428A3 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5200425A (en) * | 1976-08-04 | 1993-04-06 | Goupil Jean Jacques | Drugs containing a psoralene derivative |
| US5360816A (en) * | 1977-05-05 | 1994-11-01 | Goupil Jean Jacques | 5-methoxy psoralen used to treat psoriasis |
| US4264478A (en) * | 1978-10-30 | 1981-04-28 | Amerchol Corporation | Polyol fragrance fixatives |
| US4269851A (en) * | 1979-09-10 | 1981-05-26 | Thomas C. Elder, Inc. | 8-Aminoalkyl-4-alkylpsoralens |
| US4324703A (en) * | 1979-12-26 | 1982-04-13 | Amerchol Corporation | Polyol fragrance fixatives |
| FR2695036B1 (fr) * | 1992-09-03 | 1994-10-28 | Goupil Jean Jacques | Huile contenant du 5-méthoxypsoralène à une concentration de 60 à 100 PPM et son utilisation pour le traitement du psoriasis. |
| US6613918B1 (en) | 2000-10-20 | 2003-09-02 | Bioavailability Systems, Llc | Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates |
| WO2004037827A1 (en) | 2000-10-20 | 2004-05-06 | Bioavailability Systems, Llc | Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates |
| KR100488493B1 (ko) * | 2002-04-22 | 2005-05-11 | 한국생명공학연구원 | 궁궁이로부터 분리한 멜라닌 생합성 저해활성을 가지는화합물 및 이를 포함하는 피부미백제 |
| US7914821B2 (en) * | 2008-03-07 | 2011-03-29 | KO DA Pharmaceuticals Co., Ltd. | Pharmaceutical composition for prevention and/or treatment of bone loss |
| CN112898263B (zh) * | 2021-01-28 | 2022-03-08 | 江西中医药大学 | 一种从佛手中分离的香豆素骈木脂素化合物及其保肝用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3244729A (en) * | 1966-04-05 | Dimethoxy-x-methyl-g,y-furanocou- marin compounds | ||
| US2345635A (en) * | 1942-04-11 | 1944-04-04 | Wisconsin Alumni Res Found | Di-esters of 3,3'-methylenebis (4-hydroxycoumarin) and process of making them |
| US2889337A (en) * | 1956-07-19 | 1959-06-02 | William L Stanley | Isolation of furocoumarins |
| US3201421A (en) * | 1962-05-09 | 1965-08-17 | Dept Of Chemistry | Preparation of alkyl psoralens |
| US3553236A (en) * | 1968-12-06 | 1971-01-05 | Franco Indian Pharmaceuticals | Psoralene and isopsoralene, process for their isolation and separation |
| US3985896A (en) * | 1975-07-15 | 1976-10-12 | Smithkline Corporation | Benzophenalenofurans |
-
1976
- 1976-05-28 CH CH668876A patent/CH614957A5/xx not_active IP Right Cessation
-
1977
- 1977-05-13 BE BE177575A patent/BE854630A/xx not_active IP Right Cessation
- 1977-05-18 FR FR7715234A patent/FR2362854A1/fr active Granted
- 1977-05-20 ES ES458980A patent/ES458980A1/es not_active Expired
- 1977-05-26 LU LU77422A patent/LU77422A1/xx unknown
- 1977-05-26 US US05/800,782 patent/US4217445A/en not_active Expired - Lifetime
- 1977-05-26 IT IT24034/77A patent/IT1085806B/it active
- 1977-05-27 DE DE2724207A patent/DE2724207C2/de not_active Expired
- 1977-05-27 BR BR7703458A patent/BR7703458A/pt unknown
- 1977-05-27 SU SU772484403A patent/SU747428A3/ru active
- 1977-05-27 NL NL7705869A patent/NL7705869A/xx not_active Application Discontinuation
- 1977-05-27 CA CA279,373A patent/CA1079724A/en not_active Expired
- 1977-05-27 GB GB22601/77A patent/GB1579268A/en not_active Expired
- 1977-05-27 IN IN800/CAL/77A patent/IN155951B/en unknown
- 1977-05-27 JP JP6132077A patent/JPS52145510A/ja active Pending
- 1977-05-28 EG EG323/77A patent/EG13242A/xx active
- 1977-05-30 AU AU25607/77A patent/AU516330B2/en not_active Expired
- 1977-05-30 AR AR267838A patent/AR215634A1/es active
-
1978
- 1978-12-12 SU SU782697600A patent/SU810698A1/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| NL7705869A (nl) | 1977-11-30 |
| CA1079724A (en) | 1980-06-17 |
| BE854630A (fr) | 1977-09-01 |
| DE2724207A1 (de) | 1977-12-15 |
| SU810698A1 (ru) | 1981-03-07 |
| LU77422A1 (es) | 1977-10-10 |
| AU516330B2 (en) | 1981-05-28 |
| BR7703458A (pt) | 1978-03-14 |
| GB1579268A (en) | 1980-11-19 |
| US4217445A (en) | 1980-08-12 |
| FR2362854B1 (es) | 1980-11-14 |
| JPS52145510A (en) | 1977-12-03 |
| DE2724207C2 (de) | 1981-12-03 |
| AU2560777A (en) | 1978-12-07 |
| SU747428A3 (ru) | 1980-07-23 |
| FR2362854A1 (fr) | 1978-03-24 |
| IN155951B (es) | 1985-03-30 |
| AR215634A1 (es) | 1979-10-31 |
| IT1085806B (it) | 1985-05-28 |
| CH614957A5 (es) | 1979-12-28 |
| EG13242A (en) | 1981-03-31 |
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