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ES457421A1 - A PROCEDURE FOR THE PREPARATION OF NEW PYRIDINE DERIVATIVES. - Google Patents

A PROCEDURE FOR THE PREPARATION OF NEW PYRIDINE DERIVATIVES.

Info

Publication number
ES457421A1
ES457421A1 ES457421A ES457421A ES457421A1 ES 457421 A1 ES457421 A1 ES 457421A1 ES 457421 A ES457421 A ES 457421A ES 457421 A ES457421 A ES 457421A ES 457421 A1 ES457421 A1 ES 457421A1
Authority
ES
Spain
Prior art keywords
pyridine derivatives
procedure
preparation
new pyridine
ono2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES457421A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP51036101A external-priority patent/JPS5817463B2/en
Priority claimed from JP8245876A external-priority patent/JPS6052685B2/en
Priority claimed from JP8352276A external-priority patent/JPS539775A/en
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of ES457421A1 publication Critical patent/ES457421A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Pyridine derivatives of the formula < IMAGE > wherein R5 denotes hydrogen, lower alkyl, hydroxyl or an -ONO2 group and R6 denotes hydroxyl or a -CH2OH, -ONO2 or -CH2ONO2 group, and salts of these compounds, are prepared by reacting nicotinic acid or a reactive derivative thereof with an appropriate amine or a reactive derivative of the amine. The compounds obtained may be used for the treatment of circulatory disorders.
ES457421A 1976-04-02 1977-03-31 A PROCEDURE FOR THE PREPARATION OF NEW PYRIDINE DERIVATIVES. Expired ES457421A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP51036101A JPS5817463B2 (en) 1976-04-02 1976-04-02 Nicotinic acid amide derivatives
JP8245876A JPS6052685B2 (en) 1976-07-13 1976-07-13 Cardiovascular disease treatment
JP8352276A JPS539775A (en) 1976-07-15 1976-07-15 Pyridine derivatives and their preparation

Publications (1)

Publication Number Publication Date
ES457421A1 true ES457421A1 (en) 1978-11-16

Family

ID=27288973

Family Applications (2)

Application Number Title Priority Date Filing Date
ES457421A Expired ES457421A1 (en) 1976-04-02 1977-03-31 A PROCEDURE FOR THE PREPARATION OF NEW PYRIDINE DERIVATIVES.
ES468462A Expired ES468462A1 (en) 1976-04-02 1978-03-31 A procedure for the preparation of new derivatives of pyridine. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES468462A Expired ES468462A1 (en) 1976-04-02 1978-03-31 A procedure for the preparation of new derivatives of pyridine. (Machine-translation by Google Translate, not legally binding)

Country Status (13)

Country Link
AR (2) AR217423A1 (en)
AT (1) AT360532B (en)
AU (1) AU509591B2 (en)
CA (1) CA1088944A (en)
CH (1) CH633535A5 (en)
DE (1) DE2714713C3 (en)
DK (1) DK145608C (en)
ES (2) ES457421A1 (en)
FI (1) FI66598C (en)
FR (1) FR2346334A1 (en)
MX (1) MX5534E (en)
NL (2) NL176674C (en)
SE (1) SE436029B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0653658B2 (en) * 1984-12-17 1994-07-20 中外製薬株式会社 Stable tablet manufacturing method
EP0223811A1 (en) * 1985-05-22 1987-06-03 Beecham Group Plc Use of nicorandil or pinacidil for the treatment of peripheral vascular disease
AU3693789A (en) * 1988-05-10 1989-11-29 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) New ophthalmic preparation for treating glaucoma
US4973565A (en) * 1989-07-17 1990-11-27 Corning Incorporated Fluoroborosilicate glass and clad article
ZA91291B (en) * 1990-01-16 1991-09-25 Hoechst Ag Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof
US6417207B1 (en) 1999-05-12 2002-07-09 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
US20110082177A1 (en) * 2008-07-01 2011-04-07 Jerzy Gebicki N'-nitroxyalkylnicotinamides for the treatment of cardiovascular diseases
IT1403890B1 (en) 2010-12-28 2013-11-08 Procos Spa NICORANDIL PRODUCTION PROCESS

Also Published As

Publication number Publication date
DK145608B (en) 1982-12-27
AU2353277A (en) 1978-09-28
NL176674C (en) 1985-05-17
SE7703868L (en) 1977-10-03
CH633535A5 (en) 1982-12-15
SE436029B (en) 1984-11-05
DK145608C (en) 1983-07-11
NL930042I2 (en) 1993-09-16
FI66598B (en) 1984-07-31
ATA235077A (en) 1980-06-15
NL176674B (en) 1984-12-17
AR220907A1 (en) 1980-12-15
DK128277A (en) 1977-10-03
MX5534E (en) 1983-09-27
FR2346334A1 (en) 1977-10-28
NL7703624A (en) 1977-10-04
AR217423A1 (en) 1980-03-31
DE2714713A1 (en) 1977-10-20
FI771024A7 (en) 1977-10-03
DE2714713B2 (en) 1980-02-21
FI66598C (en) 1984-11-12
ES468462A1 (en) 1979-10-01
DE2714713C3 (en) 1980-10-16
CA1088944A (en) 1980-11-04
NL930042I1 (en) 1993-08-02
AU509591B2 (en) 1980-05-15
FR2346334B1 (en) 1980-02-01
AT360532B (en) 1981-01-12

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