ES455490A1 - PROCEDURE FOR OBTAINING 1- (ARALCOXIFENIL) -2- OR -3- (BIS-ARILALQUILAMINO) -ALCANOS. - Google Patents
PROCEDURE FOR OBTAINING 1- (ARALCOXIFENIL) -2- OR -3- (BIS-ARILALQUILAMINO) -ALCANOS.Info
- Publication number
- ES455490A1 ES455490A1 ES455490A ES455490A ES455490A1 ES 455490 A1 ES455490 A1 ES 455490A1 ES 455490 A ES455490 A ES 455490A ES 455490 A ES455490 A ES 455490A ES 455490 A1 ES455490 A1 ES 455490A1
- Authority
- ES
- Spain
- Prior art keywords
- amino
- bis
- procedure
- obtaining
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- -1 nitro, amino Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Procedimiento para la obtención de nuevos 1-(aralcoxifenil)-2- o -3-(bis-arilalquilamino)-alcanos de fórmula general I **(Fórmula)** donde cada uno de los símbolos Ar1, Ar2 y Ar3 significa un resto fenilo insustituido, o sustituido por uno o varios grupos alquilo inferior, alcoxi inferior, trifluormetilo, nitro, amino, mono-alquilo inferior-amino o di-alquilo inferior-amino, alcanoilo inferior-amino, ciano, carboxi, carbonalcoxi inferior, carbamoilo, aminometilo, mono-alquilo inferior-aminometilo o di-alquilo inferior-aminometilo o uno o varios átomos de halógeno, Ph significa un resto fenileno que, en caso dado, puede estar sustituido por uno de los sustituyentes mencionados para Ar1, n representa un número desde 0 a 4 y cada uno de los símbolos m y p representa un número de 1 a 4, r representa el número 1 o 2 y R1 significa hidrógeno o hidroxi, y las sales de estos compuestos.Procedure for obtaining new 1-(aralkoxyphenyl)-2- or -3-(bis-arylalkylamino)-alkanes of general formula I **(Formula)** where each of the symbols Ar1, Ar2 and Ar3 means a residue phenyl unsubstituted, or substituted by one or more lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino, mono-lower alkyl-amino or di-lower alkyl-amino, lower alkanoyl-amino, cyano, carboxy, carbon-lower alkoxy, carbamoyl, aminomethyl, mono-lower alkylaminomethyl or di-lower alkylaminomethyl or one or more halogen atoms, Ph is a phenylene radical which may be substituted, if appropriate, by one of the substituents mentioned for Ar1, n is a number from 0 to 4 and each of the symbols m and p represents a number from 1 to 4, r represents the number 1 or 2 and R1 means hydrogen or hydroxy, and the salts of these compounds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49494874A | 1974-08-05 | 1974-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES455490A1 true ES455490A1 (en) | 1978-01-01 |
Family
ID=23966620
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439997A Expired ES439997A1 (en) | 1974-08-05 | 1975-08-04 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455489A Expired ES455489A1 (en) | 1974-08-05 | 1977-01-31 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455491A Expired ES455491A1 (en) | 1974-08-05 | 1977-01-31 | PROCEDURE FOR OBTAINING 1- (ARALCOXIFENIL) -2- OR -3- (BIS-ARILALQUILAMINO) -ALCANOS. |
| ES455488A Expired ES455488A1 (en) | 1974-08-05 | 1977-01-31 | PROCEDURE FOR OBTAINING 1- (ARALCOXIFENIL) -2- OR -3- (BIS-ARILALQUILAMINO) -ALCANOS. |
| ES455490A Expired ES455490A1 (en) | 1974-08-05 | 1977-01-31 | PROCEDURE FOR OBTAINING 1- (ARALCOXIFENIL) -2- OR -3- (BIS-ARILALQUILAMINO) -ALCANOS. |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439997A Expired ES439997A1 (en) | 1974-08-05 | 1975-08-04 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455489A Expired ES455489A1 (en) | 1974-08-05 | 1977-01-31 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455491A Expired ES455491A1 (en) | 1974-08-05 | 1977-01-31 | PROCEDURE FOR OBTAINING 1- (ARALCOXIFENIL) -2- OR -3- (BIS-ARILALQUILAMINO) -ALCANOS. |
| ES455488A Expired ES455488A1 (en) | 1974-08-05 | 1977-01-31 | PROCEDURE FOR OBTAINING 1- (ARALCOXIFENIL) -2- OR -3- (BIS-ARILALQUILAMINO) -ALCANOS. |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5141345A (en) |
| AT (1) | AT340388B (en) |
| BE (1) | BE832082A (en) |
| CA (1) | CA1069923A (en) |
| CH (5) | CH612913A5 (en) |
| DE (1) | DE2534339A1 (en) |
| DK (1) | DK317175A (en) |
| ES (5) | ES439997A1 (en) |
| FI (1) | FI752095A7 (en) |
| FR (1) | FR2281105A1 (en) |
| GB (1) | GB1504604A (en) |
| HU (1) | HU175581B (en) |
| IE (1) | IE42335B1 (en) |
| IL (1) | IL47813A (en) |
| NL (1) | NL7509270A (en) |
| NO (1) | NO752621L (en) |
| SE (1) | SE7508181L (en) |
| ZA (2) | ZA754192B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5726653A (en) * | 1980-05-09 | 1982-02-12 | Ciba Geigy Ag | Substituted phenyl ether |
| DE602005022572D1 (en) | 2004-03-12 | 2010-09-09 | Lilly Co Eli | ANTAGONISTS OF THE OPIOID RECEPTOR |
-
1975
- 1975-07-01 ZA ZA00754192A patent/ZA754192B/en unknown
- 1975-07-11 DK DK317175A patent/DK317175A/en unknown
- 1975-07-17 SE SE7508181A patent/SE7508181L/en unknown
- 1975-07-21 FI FI752095A patent/FI752095A7/fi not_active Application Discontinuation
- 1975-07-23 NO NO752621A patent/NO752621L/no unknown
- 1975-07-25 IL IL47813A patent/IL47813A/en unknown
- 1975-07-30 CH CH25579A patent/CH612913A5/en not_active IP Right Cessation
- 1975-07-30 CH CH25279A patent/CH612910A5/en not_active IP Right Cessation
- 1975-07-30 GB GB31893/75A patent/GB1504604A/en not_active Expired
- 1975-07-30 CH CH25479A patent/CH612912A5/en not_active IP Right Cessation
- 1975-07-30 CH CH25379A patent/CH612911A5/en not_active IP Right Cessation
- 1975-07-30 CH CH993575A patent/CH612909A5/en not_active IP Right Cessation
- 1975-08-01 FR FR7524088A patent/FR2281105A1/en active Granted
- 1975-08-01 DE DE19752534339 patent/DE2534339A1/en not_active Withdrawn
- 1975-08-01 CA CA232,735A patent/CA1069923A/en not_active Expired
- 1975-08-01 IE IE1724/75A patent/IE42335B1/en unknown
- 1975-08-01 HU HU75CI1597A patent/HU175581B/en unknown
- 1975-08-04 BE BE158907A patent/BE832082A/en unknown
- 1975-08-04 AT AT604275A patent/AT340388B/en not_active IP Right Cessation
- 1975-08-04 ZA ZA00755018A patent/ZA755018B/en unknown
- 1975-08-04 NL NL7509270A patent/NL7509270A/en not_active Application Discontinuation
- 1975-08-04 ES ES439997A patent/ES439997A1/en not_active Expired
- 1975-08-05 JP JP50094800A patent/JPS5141345A/en active Pending
-
1977
- 1977-01-31 ES ES455489A patent/ES455489A1/en not_active Expired
- 1977-01-31 ES ES455491A patent/ES455491A1/en not_active Expired
- 1977-01-31 ES ES455488A patent/ES455488A1/en not_active Expired
- 1977-01-31 ES ES455490A patent/ES455490A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE832082A (en) | 1976-02-04 |
| CA1069923A (en) | 1980-01-15 |
| AU8362675A (en) | 1977-02-10 |
| CH612910A5 (en) | 1979-08-31 |
| NL7509270A (en) | 1976-02-09 |
| FR2281105B1 (en) | 1980-02-08 |
| HU175581B (en) | 1980-09-28 |
| GB1504604A (en) | 1978-03-22 |
| ES455489A1 (en) | 1978-01-01 |
| ZA754192B (en) | 1976-06-30 |
| AT340388B (en) | 1977-12-12 |
| ZA755018B (en) | 1976-07-28 |
| IL47813A0 (en) | 1975-10-15 |
| DE2534339A1 (en) | 1976-02-19 |
| IL47813A (en) | 1979-07-25 |
| ES439997A1 (en) | 1977-06-16 |
| CH612913A5 (en) | 1979-08-31 |
| ES455491A1 (en) | 1978-01-01 |
| JPS5141345A (en) | 1976-04-07 |
| IE42335B1 (en) | 1980-07-16 |
| DK317175A (en) | 1976-02-06 |
| CH612911A5 (en) | 1979-08-31 |
| FI752095A7 (en) | 1976-02-06 |
| ES455488A1 (en) | 1978-01-01 |
| ATA604275A (en) | 1977-04-15 |
| SE7508181L (en) | 1976-02-06 |
| CH612912A5 (en) | 1979-08-31 |
| IE42335L (en) | 1976-02-05 |
| FR2281105A1 (en) | 1976-03-05 |
| NO752621L (en) | 1976-02-06 |
| CH612909A5 (en) | 1979-08-31 |
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