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ES455177A1 - Un procedimiento para la preparacion de nuevos derivados de 3-aciloximetil-alfa2-cefema. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 3-aciloximetil-alfa2-cefema.

Info

Publication number
ES455177A1
ES455177A1 ES455177A ES455177A ES455177A1 ES 455177 A1 ES455177 A1 ES 455177A1 ES 455177 A ES455177 A ES 455177A ES 455177 A ES455177 A ES 455177A ES 455177 A1 ES455177 A1 ES 455177A1
Authority
ES
Spain
Prior art keywords
acycloxymethyl
preparing
cephem compounds
acyl chloride
cephem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES455177A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES455177A1 publication Critical patent/ES455177A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Nuevo procedimiento caracterizado por hacer reaccionar un éster de sulfóxido de 3-exometilencefama con una mezcla de un ácido carboxílico C1-C4 y un anhídrido de ácido C1-C4 correspondiente a una temperatura de 70ºC a 130ºC aproximadamente, para producir la correspondiente 3-aciloximetil-delta2-cefema, que es útil como intermediario en la preparación de cefalosporinas antibióticamente activas. Los antibióticos de cefalosporina con un grupo aciloximetilo en el átomo de carbono C3 del núcleo de cefema son muy conocidos en el campo de las cefalosporinas. Esta invención está dirigida a un procedimiento para preparar compuestos de 3-aciloximetil-delta2-cefema, cuyos compuestos se pueden convertir fácilmente, por medio de técnicas conocidas, en los antibióticos de 3-aciloximetilcefalosporina mencionadas anteriormente.
ES455177A 1976-01-19 1977-01-19 Un procedimiento para la preparacion de nuevos derivados de 3-aciloximetil-alfa2-cefema. Expired ES455177A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/650,585 US4031082A (en) 1976-01-19 1976-01-19 Process for preparing 3-acycloxymethyl-2-cephem compounds

Publications (1)

Publication Number Publication Date
ES455177A1 true ES455177A1 (es) 1978-04-16

Family

ID=24609491

Family Applications (1)

Application Number Title Priority Date Filing Date
ES455177A Expired ES455177A1 (es) 1976-01-19 1977-01-19 Un procedimiento para la preparacion de nuevos derivados de 3-aciloximetil-alfa2-cefema.

Country Status (3)

Country Link
US (1) US4031082A (es)
CA (1) CA1073899A (es)
ES (1) ES455177A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500010A (en) * 1975-10-01 1978-02-08 Pierrel Spa 3,7-disubstituted cephalosporins and their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929775A (en) * 1970-12-08 1975-12-30 Takeda Chemical Industries Ltd Process for producing cephalosporin derivatives
US3932393A (en) * 1971-02-25 1976-01-13 Eli Lilly And Company 3-Methylenecephalosporins and process for production thereof

Also Published As

Publication number Publication date
US4031082A (en) 1977-06-21
CA1073899A (en) 1980-03-18

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