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ES446598A1 - Piperazine derivatives - Google Patents

Piperazine derivatives

Info

Publication number
ES446598A1
ES446598A1 ES446598A ES446598A ES446598A1 ES 446598 A1 ES446598 A1 ES 446598A1 ES 446598 A ES446598 A ES 446598A ES 446598 A ES446598 A ES 446598A ES 446598 A1 ES446598 A1 ES 446598A1
Authority
ES
Spain
Prior art keywords
hydrogen
formula
see formula
alcoholic
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES446598A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parcor SARL
Original Assignee
Parcor SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parcor SARL filed Critical Parcor SARL
Publication of ES446598A1 publication Critical patent/ES446598A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for preparing piperazine compounds of formula: **(See formula)** in which R1 is halogen, alcoholic, alkoxy or trifluoromethyl, R2 is hydrogen and R3 is an alcoholic or cycloalkoxy radical or R2 and R3 form, together with the nitrogen atom to which they are attached a saturated heterocycle of 4 to 8 chains that they may have, as a second heteroatom, an oxygen or nitrogen atom, characterized in that it consists of condensing a phenylpiperizine of the formula: **(See formula)** on a reagent B, in which: A is hydrogen when B is (see formula), while A is - (CH2) 3- X when B is (see formula), being X a halogen and, only in the case in which R2 is hydrogen, A is - (CH2) 3NH2 when B is R4 = 0, being the divalent radical derived from R3 by removal of a hydrogen in the atom of root carbon, followed by condensation, in the latter case, of a reduction of the imine obtained by means of a reducing agent. (Machine-translation by Google Translate, not legally binding)
ES446598A 1975-04-07 1976-04-01 Piperazine derivatives Expired ES446598A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7510729A FR2306694A1 (en) 1975-04-07 1975-04-07 DERIVATIVES OF PIPERAZINE

Publications (1)

Publication Number Publication Date
ES446598A1 true ES446598A1 (en) 1977-06-16

Family

ID=9153579

Family Applications (1)

Application Number Title Priority Date Filing Date
ES446598A Expired ES446598A1 (en) 1975-04-07 1976-04-01 Piperazine derivatives

Country Status (10)

Country Link
JP (1) JPS51118780A (en)
BE (1) BE840326A (en)
DE (1) DE2609746A1 (en)
DK (1) DK140142B (en)
ES (1) ES446598A1 (en)
FR (1) FR2306694A1 (en)
GB (1) GB1490507A (en)
IE (1) IE43222B1 (en)
LU (1) LU74701A1 (en)
NL (1) NL7603508A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU532411B2 (en) * 1979-03-01 1983-09-29 Duphar International Research B.V. Phenyl piperazine derivatives
US4452798A (en) * 1982-06-22 1984-06-05 Warner-Lambert Company 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents
US4457931A (en) * 1982-09-27 1984-07-03 Selvi & C. S.P.A. Piperazine derivatives with anticholinergic and/or antihistaminic activity
IL162859A0 (en) * 2002-02-05 2005-11-20 Novo Nordisk As Novel aryl-and heteroarylpiperazines
CN103110635A (en) 2005-07-04 2013-05-22 海波因特制药有限责任公司 Histamine H3 receptor antagonist
WO2007135111A1 (en) 2006-05-23 2007-11-29 High Point Pharmaceuticals, Llc 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ' ] -bipyridine and its use as a medicament
ATE538116T1 (en) 2006-05-29 2012-01-15 High Point Pharmaceuticals Llc 3-(1,3-BENYODIOXOL-5-YL)-6-(4-CYCLOPROPYLPIPERAZINE-1-YL)-PYRIDAZINE, ITS SALTS AND SOLVATES AND THEIR USE AS A HISTAMINE H3 RECEPTOR ANTAGONIST
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists

Also Published As

Publication number Publication date
JPS51118780A (en) 1976-10-18
NL7603508A (en) 1976-10-11
DE2609746A1 (en) 1976-10-14
DK140142B (en) 1979-06-25
FR2306694B1 (en) 1980-01-04
BE840326A (en) 1976-10-04
GB1490507A (en) 1977-11-02
DK125476A (en) 1976-10-08
IE43222B1 (en) 1981-01-14
DK140142C (en) 1979-11-19
FR2306694A1 (en) 1976-11-05
LU74701A1 (en) 1976-11-11
IE43222L (en) 1976-10-07

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