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ES430341A1 - PROCEDURE FOR THE PREPARATION OF BENZAMINES DISUSTITUTED IN POSITIONS 2 AND 5. - Google Patents

PROCEDURE FOR THE PREPARATION OF BENZAMINES DISUSTITUTED IN POSITIONS 2 AND 5.

Info

Publication number
ES430341A1
ES430341A1 ES430341A ES430341A ES430341A1 ES 430341 A1 ES430341 A1 ES 430341A1 ES 430341 A ES430341 A ES 430341A ES 430341 A ES430341 A ES 430341A ES 430341 A1 ES430341 A1 ES 430341A1
Authority
ES
Spain
Prior art keywords
formula
radical
molecular weight
low molecular
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES430341A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Original Assignee
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dEtudes Scientifiques et Industrielles de lIle de France SA filed Critical Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Publication of ES430341A1 publication Critical patent/ES430341A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Procedure for preparing disubstituted benzamides in positions 2 and 5 of the general formula **(See formula)** as well as its addition salts with pharmaceutically acceptable organic or mineral acids and its quaternary ammonium salts, being in formula (I) - A, or a low molecular weight mono- or dialcoylamino radical, in which the alcohol groups can be linked forming a cycle with or without nitrogen, oxygen or sulfur, and the nitrogen atom can, when the cycle contains it, be attached to a low molecular weight alcohol group, the rings being thus formed, for example pyrrolidinyl, piperidinyl, imidazolidinyl, piperazine, morpholino and thiazolidinyl, or a heterocyclic radical of the form **(See formula)** where R is a low molecular weight alcohol radical, or alkenyl, and m an integer of less than 4, and - B is a low molecular weight alcohol radical or an alkenyl radical, and n = lo2; y-X is an amino, mono- or dialcoylamino radical, alcoholic or alkenyl, whose process consists of starting from a benzoic acid disubstituted in positions 2 and 5, of the formula **(See formula)** where B and X have the same meanings as above, and make it react with an amine of formula H2N (CH2) nA (III) where A has the same meaning as above, in the presence of phosphoric anhydride, to obtain the desired benzamide of formula (I). (Machine-translation by Google Translate, not legally binding)
ES430341A 1973-09-28 1974-09-24 PROCEDURE FOR THE PREPARATION OF BENZAMINES DISUSTITUTED IN POSITIONS 2 AND 5. Expired ES430341A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7335095A FR2245628B1 (en) 1973-09-28 1973-09-28

Publications (1)

Publication Number Publication Date
ES430341A1 true ES430341A1 (en) 1977-05-01

Family

ID=9125782

Family Applications (1)

Application Number Title Priority Date Filing Date
ES430341A Expired ES430341A1 (en) 1973-09-28 1974-09-24 PROCEDURE FOR THE PREPARATION OF BENZAMINES DISUSTITUTED IN POSITIONS 2 AND 5.

Country Status (11)

Country Link
JP (1) JPS5715752B2 (en)
AR (1) AR205172A1 (en)
AT (1) AT338235B (en)
CA (1) CA1055502A (en)
CY (1) CY974A (en)
DE (1) DE2444587A1 (en)
ES (1) ES430341A1 (en)
FI (1) FI59087C (en)
FR (1) FR2245628B1 (en)
GB (1) GB1447329A (en)
IE (1) IE40402B1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2418226A1 (en) * 1978-02-27 1979-09-21 Synthelabo METHOXY-2 ALKYLTHIO-5 BENZAMIDES AND THEIR THERAPEUTIC APPLICATION
FR2418225A1 (en) * 1978-02-27 1979-09-21 Synthelabo N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv.
FR2447910A2 (en) * 1979-02-05 1980-08-29 Synthelabo Neuroleptics used to treat psychoses and depression - are N 1-cycloalkyl-alkyl-2-pyrrolidinyl-methyl 2-methoxy 5-alkylthio-benzamide derivs.
FR2478093A1 (en) * 1980-03-12 1981-09-18 Ile De France Prepn. of N-pyrrolidinyl methyl-2-methoxy-5-sulphamoyl benzamide cpds. - from 2-methoxy-5- chlorosulphonyl-benzoic acid cpds.
WO2003055857A1 (en) * 2001-12-28 2003-07-10 Farmaceutsko-Hemijska Industrija 'zdravlje' A process for synthesis of heterocyclic aminoalkyl benzamides

Also Published As

Publication number Publication date
IE40402L (en) 1975-03-28
AT338235B (en) 1977-08-10
FI59087B (en) 1981-02-27
ATA770474A (en) 1976-12-15
JPS5715752B2 (en) 1982-04-01
GB1447329A (en) 1976-08-25
JPS5059350A (en) 1975-05-22
FR2245628A1 (en) 1975-04-25
DE2444587A1 (en) 1975-04-03
CY974A (en) 1978-12-22
CA1055502A (en) 1979-05-29
FI276274A7 (en) 1975-03-29
FR2245628B1 (en) 1977-03-11
AR205172A1 (en) 1976-04-12
IE40402B1 (en) 1979-05-23
FI59087C (en) 1981-06-10

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