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ES439235A1 - PROCEDURE FOR THE PREPARATION OF BUFADIENOLID-ETERES AND BUFATRIENOLID-ETERES. - Google Patents

PROCEDURE FOR THE PREPARATION OF BUFADIENOLID-ETERES AND BUFATRIENOLID-ETERES.

Info

Publication number
ES439235A1
ES439235A1 ES439235A ES439235A ES439235A1 ES 439235 A1 ES439235 A1 ES 439235A1 ES 439235 A ES439235 A ES 439235A ES 439235 A ES439235 A ES 439235A ES 439235 A1 ES439235 A1 ES 439235A1
Authority
ES
Spain
Prior art keywords
carbon atoms
radical
straight
branched
double bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES439235A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laevosan GmbH and Co KG
Original Assignee
Laevosan GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laevosan GmbH and Co KG filed Critical Laevosan GmbH and Co KG
Publication of ES439235A1 publication Critical patent/ES439235A1/en
Priority to ES470578A priority Critical patent/ES470578A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C07J19/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of bufadienolid-ethers and bufatrienolid-ethers of the general formula **(See formula)** where X represents a double bond between carbon atoms 4 and 5 or an epoxide group, R'is a methyl, formyl or methylol group, and R is hydrogen; a straight or branched alcohol radical with 1 to 16 carbon atoms; a straight or branched alkeline radical with 2 to 6 carbon atoms; an otynyl radical; a straight or branched alkoxy group with 2 to 11 carbon atoms; a cycloaliphatic radical, in which the CH2 group that is suspended from R forms with the radical R a ring of 6 to 12 carbon atoms; an aromatic or aliphatic-aromatic radical such as for example a phenyl, phenylmethyl, 2-phenylethyl or 3-phenylpropyl radical; straight or branched dialkoxylaminoalcohyl radicals with 1 to 7 carbon atoms, nitrogen being tertiary and being able to carry two alcohol radicals with 1 to 4 carbon atoms; the straight or branched aliphatic chains may in each case be substituted with nitrogen or oxygen containing heterocycles, such as, for example, pyridine, piperazine, pyrrolidine, furyl, tetrahydrofuryl or morpholino groups, or substituted with halogen such as chlorine or bromine; where, when X signifies a double bond and R'signifies a methyl group, R cannot be any hydrogen atom; which compounds are new, with the following exceptions: R'= methyl, X = double bond, R = alcohol with 4 or 5 carbon atoms; R'= formyl, X = double bond, R = II or alcohol with 1 to 5 carbon atoms, characterized in that a bufadienolid-glycoside or bufatrienolid-glycoside of the general formula is reacted **(See formula)** where X and R1 have the above meanings, with a diazoalkane of the general formula R CH N2, (III) where R has the above meanings, in an inert solvent. (Machine-translation by Google Translate, not legally binding)
ES439235A 1974-07-09 1975-07-08 PROCEDURE FOR THE PREPARATION OF BUFADIENOLID-ETERES AND BUFATRIENOLID-ETERES. Expired ES439235A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES470578A ES470578A2 (en) 1975-07-08 1978-06-07 Improvements introduced in the object of the main patent n. 439.235 submitted on 8.7.75, by: procedure for the preparation of bufadienolid-eteres and bufatrienolid-eteres (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT566274A AT349159B (en) 1974-07-09 1974-07-09 PROCESS FOR THE PREPARATION OF NEW BUFADIENOLIDE AND BUFATRIENOLIDE Aethers

Publications (1)

Publication Number Publication Date
ES439235A1 true ES439235A1 (en) 1977-02-16

Family

ID=3578264

Family Applications (1)

Application Number Title Priority Date Filing Date
ES439235A Expired ES439235A1 (en) 1974-07-09 1975-07-08 PROCEDURE FOR THE PREPARATION OF BUFADIENOLID-ETERES AND BUFATRIENOLID-ETERES.

Country Status (8)

Country Link
AT (1) AT349159B (en)
CH (1) CH615200A5 (en)
DE (1) DE2528496C3 (en)
ES (1) ES439235A1 (en)
FI (1) FI55669C (en)
FR (1) FR2277592A1 (en)
IT (1) IT7525228A1 (en)
SE (1) SE414180B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT368523B (en) * 1977-06-08 1982-10-25 Laevosan Gmbh & Co Kg METHOD FOR PRODUCING BUFADIENOLID AND BUFATRIENOLIDAETHERS
ITMI20011412A1 (en) * 2001-07-04 2003-01-04 Consiglio Nazionale Ricerche NEW DIAZODERIVATI AND PROCESS FOR THEIR PREPARATION

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130587C (en) * 1966-12-22
DE1643665B1 (en) * 1967-09-20 1971-02-18 Boehringer Mannheim Gmbh Novel digoxin ethers and processes for making the same
DE1905725A1 (en) * 1969-02-06 1970-08-20 Boehringer Mannheim Gmbh Acovenoside A derivatives and processes for making the same
DE1910207C3 (en) * 1969-02-28 1978-04-13 Knoll Ag, 6700 Ludwigshafen Process for their manufacture

Also Published As

Publication number Publication date
IT7525228A1 (en) 1977-01-09
DE2528496A1 (en) 1976-01-29
DE2528496C3 (en) 1981-07-23
FI55669C (en) 1979-09-10
DE2528496B2 (en) 1980-07-31
FR2277592A1 (en) 1976-02-06
ATA566274A (en) 1978-08-15
CH615200A5 (en) 1980-01-15
SE414180B (en) 1980-07-14
IT1054639B (en) 1981-11-30
FI55669B (en) 1979-05-31
FI751980A7 (en) 1976-01-10
FR2277592B1 (en) 1979-10-12
AT349159B (en) 1979-03-26
SE7507813L (en) 1976-01-12

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