ES439073A1 - Manufacture of novel phenothiazine derivative - Google Patents
Manufacture of novel phenothiazine derivativeInfo
- Publication number
- ES439073A1 ES439073A1 ES439073A ES439073A ES439073A1 ES 439073 A1 ES439073 A1 ES 439073A1 ES 439073 A ES439073 A ES 439073A ES 439073 A ES439073 A ES 439073A ES 439073 A1 ES439073 A1 ES 439073A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- radical
- part contains
- general formula
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000001484 phenothiazinyl group Chemical class C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- -1 methylthio, methylsulfonyl Chemical group 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for preparing phenothiazine derivatives, of general formula: **(See formula)** in which X represents a methylthio, methylsulfonyl or dimethylsulfamoyl radical, A represents a radical - (CH2) 3- or -CH- (CH3) -CH2-, R1 represents a hydrogen atom or an alkanoyl radical whose alkyl part contains 1 to 16 carbon atoms, alkenoyl whose alkenyl part contains 2 to 16 carbon atoms; as well as its addition salts with acids; characterized in that a product of general formula is treated in an acid medium: **(See formula)** in which X, A and R1 are defined as above and R represents an alkyl radical containing 1 to 10 carbon atoms or phenylalkyl whose alkyl part contains 1 to 4 carbon atoms or tetrahydropyranyl, and then the product obtained is eventually transformed into an addition salt with an acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7437295A FR2290907A2 (en) | 1974-11-12 | 1974-11-12 | 10-((4-hydroxyethylpiperidino)alkyl)-phenothiazines - with antiemetic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES439073A1 true ES439073A1 (en) | 1977-03-01 |
Family
ID=9144859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439073A Expired ES439073A1 (en) | 1974-11-12 | 1975-07-02 | Manufacture of novel phenothiazine derivative |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS54109988A (en) |
| AR (1) | AR206441A1 (en) |
| CH (1) | CH599955A5 (en) |
| ES (1) | ES439073A1 (en) |
| FR (1) | FR2290907A2 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1212031A (en) * | 1957-10-21 | 1960-03-21 | Rhone Poulenc Sa | Phenothiazine derivatives substituted on nitrogen with a basic chain comprising a heterocycle and their preparation |
-
1974
- 1974-11-12 FR FR7437295A patent/FR2290907A2/en active Granted
-
1975
- 1975-01-01 AR AR260779A patent/AR206441A1/en active
- 1975-01-21 CH CH1069577A patent/CH599955A5/xx not_active IP Right Cessation
- 1975-07-02 ES ES439073A patent/ES439073A1/en not_active Expired
-
1978
- 1978-05-22 JP JP6008178A patent/JPS54109988A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AR206441A1 (en) | 1976-07-23 |
| FR2290907B2 (en) | 1978-08-18 |
| FR2290907A2 (en) | 1976-06-11 |
| CH599955A5 (en) | 1978-06-15 |
| JPS54109988A (en) | 1979-08-29 |
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