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ES438695A1 - A procedure for the preparation of prostate acid derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of prostate acid derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES438695A1
ES438695A1 ES438695A ES438695A ES438695A1 ES 438695 A1 ES438695 A1 ES 438695A1 ES 438695 A ES438695 A ES 438695A ES 438695 A ES438695 A ES 438695A ES 438695 A1 ES438695 A1 ES 438695A1
Authority
ES
Spain
Prior art keywords
formula
products
mixture
translation
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES438695A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES438695A1 publication Critical patent/ES438695A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A process for the preparation of the prostanoic acid derivatives of formula i: ** (see formula) ** Wherein r represents a hydrogen atom or an alkyl radical having 1 to 4 carbon atoms, m is an integer equal to 3, 4 or 5, n is an integer equal to 2, 3 or 4, r is either a straight or branched alkyl radical, saturated or unsaturated, having 1 to 4 carbon atoms, or a cycloalkyl radical having from 3 to 6 carbon atoms, and which may, optionally, contain a double bond, and its salts when r represents hydrogen, which is characterized by reacting a product of formula ii ** (see formula) ** Wherein r, m and n have the above meaning, with an oxidation agent, to obtain a product of formula iii: ** (see formula) ** Where r, m and n have the above meaning, treat it with an organomagnesium derivative of formula R' mg x Wherein x represents a halogen atom and r 'has the meaning already given, to obtain a mixture of products having the formula iv ** (see formula) ** Mixture that can be divided into each of the products that make it up, and then treat the previous mixture of the products of formula iv, or one of these products, with an acid, to obtain a mixture of products that have the same formulas ** (see formula) ** Corresponding to products of formula i, or to obtain one of these products, the mixture possibly being divided into each of the products that make it up, mixture or products that are salified, if desired, when r = h. (Machine-translation by Google Translate, not legally binding)
ES438695A 1974-06-20 1975-06-19 A procedure for the preparation of prostate acid derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES438695A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7421424A FR2275438A1 (en) 1974-06-20 1974-06-20 Prostanoic acid derivs - as hypotensives, contractors of smooth muscle and antagonists of bronchoconstriction (DK160276)

Publications (1)

Publication Number Publication Date
ES438695A1 true ES438695A1 (en) 1977-04-01

Family

ID=9140296

Family Applications (1)

Application Number Title Priority Date Filing Date
ES438695A Expired ES438695A1 (en) 1974-06-20 1975-06-19 A procedure for the preparation of prostate acid derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (6)

Country Link
JP (1) JPS5134130A (en)
CA (1) CA1073453A (en)
CH (1) CH605730A5 (en)
DK (1) DK279575A (en)
ES (1) ES438695A1 (en)
FR (1) FR2275438A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4498523A (en) * 1983-05-12 1985-02-12 Aluminum Company Of America Continuous method for reclaiming, melting and casting aluminum scrap
IT1226969B (en) * 1984-01-05 1991-02-26 Istituto Biochimico Italiano PERFECTED PROCEDURE FOR THE PREPARATION OF 7- (2) HEXYL-5- HYDROXY- CYCLOPENTYL) -EPTANOIC ACID
JPS61133334A (en) * 1984-11-30 1986-06-20 Hitachi Cable Ltd Recovering method of silver
JPH01188637A (en) * 1988-01-21 1989-07-27 Shintouyou Kinzoku Kogyo Kk Treatment of aluminum can scrap

Also Published As

Publication number Publication date
CA1073453A (en) 1980-03-11
CH605730A5 (en) 1978-10-13
JPS5134130A (en) 1976-03-23
FR2275438A1 (en) 1976-01-16
DK279575A (en) 1975-12-21
FR2275438B1 (en) 1978-01-13

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