ES438602A1 - Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining new diazepine derivatives of general formula I **(See formula)** wherein R1 signifies hydrogen or an alkyl group with 1 to 3 carbon atoms and R2 and R3 signify hydrogen, alkyl groups with 1 to 6 carbon atoms or hydroxyalkyl groups with 2 to 6 carbon atoms, dialkylaminoalkyl groups with a total of 4 to 7 carbon atoms, or aralkyl groups with 7 to 9 carbon atoms, with the lower alkyl groups R2 and R3 being in the β or γ position be linked together directly or also through an oxygen atom, the imino group, an alkyloimino or hydroxyalkyloimino group with a maximum of 4 carbon atoms to a bivalent residue with a total of a maximum of 10 carbon atoms and rings A and B can be substituted by halogen up to atomic number 35, alkyl or alkoxy groups, in each case with 1 to 6 carbon atoms, trifluoromethyl groups or nitro groups, as well as the 5-oxides and addition salts of the compounds of the general formula I with inorganic or organic acids, characterized in that an aldehyde of general formula II **(See formula)** Where R1 has the meaning indicated under formula I and rings A and B may be substituted as indicated therein, it is reacted with a compound of general formula **(See formula)** where R2 and R2 have the meaning indicated under formula I, in the presence of an alkali metal cyanide and a selective oxidation agent and the reaction product, if desired, is transformed by oxidation into its 5-oxide or, in if desired, in an addition salt with an inorganic or organic acid. (Machine-translation by Google Translate, not legally binding)