ES435756A1 - Procedure for the preparation of aromatic amidas of heterociclic compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of aromatic amidas of heterociclic compounds. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES435756A1 ES435756A1 ES435756A ES435756A ES435756A1 ES 435756 A1 ES435756 A1 ES 435756A1 ES 435756 A ES435756 A ES 435756A ES 435756 A ES435756 A ES 435756A ES 435756 A1 ES435756 A1 ES 435756A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- preparation
- legally binding
- google translate
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 241000670727 Amida Species 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000008430 aromatic amides Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- -1 hydroxy, nitro, amino Chemical group 0.000 abstract 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 abstract 1
- 229910001507 metal halide Inorganic materials 0.000 abstract 1
- 150000005309 metal halides Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
Process for the preparation of aromatic amides of heterocyclic compounds of general structure (i-a): ** (see formula) ** Where X is chlorine or bromine; R'1 is lower alkyl or lower alkenyl; Alk is a straight or branched chain alkyl or alkenyl containing up to 6 carbon atoms; and r'3, r'4 and r'5 which may be different from each other, are selected from hydrogen, halogen, lower alkoxy, hydroxy, nitro, amino, mono- or dialkylamino, trifluoro-alkyl, or two of them together they form a motilen dioxi group, Characterized in that the reaction is carried out between the N- [4 '- (1'-arylalkyl) piporidyl] -4-amino-2-alkoxy bonzamides of structure (II): ** (see formula) ** Where r 1, r 3, r 4, r 5 and alk have been defined above, with a halogen (chlorine or bromine) in a solvent such as acetic acid and in the presence of a metal halide heavy as ferric chloride or aluminum chloride and at a temperature between 5 and 50º c; and once the reaction is completed, the mixture is poured into water, alkalized and the insoluble product is separated. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB12572/74A GB1507462A (en) | 1974-03-21 | 1974-03-21 | N-heterocyclic substituted benzamides methods for their preparation and compositions containing them |
| GB3540274 | 1974-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES435756A1 true ES435756A1 (en) | 1977-04-01 |
Family
ID=26249107
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES435753A Expired ES435753A1 (en) | 1974-03-21 | 1975-03-18 | PROCEDURE FOR THE PREPARATION OF AROMATIC AMIDES OF HETEROCICLIC COMPOUNDS. |
| ES435757A Expired ES435757A1 (en) | 1974-03-21 | 1975-03-18 | PROCEDURE FOR THE PREPARATION OF AROMATIC AMIDES OF HETEROCICLIC COMPOUNDS. |
| ES435756A Expired ES435756A1 (en) | 1974-03-21 | 1975-03-18 | Procedure for the preparation of aromatic amidas of heterociclic compounds. (Machine-translation by Google Translate, not legally binding) |
| ES435754A Expired ES435754A1 (en) | 1974-03-21 | 1975-03-18 | PROCEDURE FOR THE PREPARATION OF AROMATIC AMIDES OF HETEROCICLIC COMPOUNDS. |
| ES435755A Expired ES435755A1 (en) | 1974-03-21 | 1975-03-18 | PROCEDURE FOR THE PREPARATION OF AROMATIC AMIDES OF HETEROCICLIC COMPOUNDS. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES435753A Expired ES435753A1 (en) | 1974-03-21 | 1975-03-18 | PROCEDURE FOR THE PREPARATION OF AROMATIC AMIDES OF HETEROCICLIC COMPOUNDS. |
| ES435757A Expired ES435757A1 (en) | 1974-03-21 | 1975-03-18 | PROCEDURE FOR THE PREPARATION OF AROMATIC AMIDES OF HETEROCICLIC COMPOUNDS. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES435754A Expired ES435754A1 (en) | 1974-03-21 | 1975-03-18 | PROCEDURE FOR THE PREPARATION OF AROMATIC AMIDES OF HETEROCICLIC COMPOUNDS. |
| ES435755A Expired ES435755A1 (en) | 1974-03-21 | 1975-03-18 | PROCEDURE FOR THE PREPARATION OF AROMATIC AMIDES OF HETEROCICLIC COMPOUNDS. |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS584019B2 (en) |
| AR (1) | AR216043A1 (en) |
| CH (1) | CH602641A5 (en) |
| DK (1) | DK147854C (en) |
| ES (5) | ES435753A1 (en) |
| FI (1) | FI60200C (en) |
| FR (1) | FR2264530A1 (en) |
| KE (1) | KE2900A (en) |
| NL (1) | NL159660B (en) |
| NO (1) | NO144108C (en) |
| SE (1) | SE427750B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1513631A (en) * | 1976-02-17 | 1978-06-07 | Gallardo Antonio Sa | Piperidine derivatives |
| GB1561023A (en) * | 1977-04-22 | 1980-02-13 | Beecham Group Ltd | 2-methoxy - 5 - chloro aniline derivatives |
| FR2446274A1 (en) * | 1979-01-15 | 1980-08-08 | Delalande Sa | 5-Acetoxy:methyl and 5-chloro:methyl 2-methoxy benzamide(s) - and related cpds. have neuroleptic activity and are used for psychic disorders |
| EP0343307A1 (en) * | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | 4-Piperidinealkanamine derivatives |
| FR2674849B1 (en) * | 1991-04-02 | 1994-12-23 | Logeais Labor Jacques | NOVEL N-CYCLOHEXYL BENZAMIDES OR THIOBENZAMIDES DERIVATIVES, THEIR PREPARATIONS AND THEIR THERAPEUTIC APPLICATIONS. |
| FR2766486B1 (en) * | 1997-07-25 | 1999-09-17 | Logeais Labor Jacques | HIGH AND LOW GASTROINTESTINAL MOTOR STIMULATING BENZAMIDE CYCLOALKYLES |
| FR2766484B1 (en) * | 1997-07-25 | 1999-09-17 | Logeais Labor Jacques | NOVEL STIMULATING BENZAMIDE DERIVATIVES OF HIGH AND LOW GASTROINTESTINAL MOTORITY |
| JP4949387B2 (en) * | 2005-06-02 | 2012-06-06 | エフ．ホフマン−ラ ロシュ アーゲー | Piperidin-4-ylamide derivatives and their use as SST receptor subtype 5 antagonists |
| KR100976063B1 (en) * | 2007-03-16 | 2010-08-17 | 동아제약주식회사 | Novel benzamide derivative compounds and preparation methods thereof |
| WO2013081400A2 (en) * | 2011-11-29 | 2013-06-06 | 주식회사 비보존 | Novel benzamide derivative and use thereof |
-
1975
- 1975-03-17 AR AR257994A patent/AR216043A1/en active
- 1975-03-18 ES ES435753A patent/ES435753A1/en not_active Expired
- 1975-03-18 ES ES435757A patent/ES435757A1/en not_active Expired
- 1975-03-18 ES ES435756A patent/ES435756A1/en not_active Expired
- 1975-03-18 ES ES435754A patent/ES435754A1/en not_active Expired
- 1975-03-18 ES ES435755A patent/ES435755A1/en not_active Expired
- 1975-03-20 SE SE7503196A patent/SE427750B/en not_active IP Right Cessation
- 1975-03-20 DK DK117675A patent/DK147854C/en not_active IP Right Cessation
- 1975-03-20 NO NO750957A patent/NO144108C/en unknown
- 1975-03-20 FI FI750825A patent/FI60200C/en not_active IP Right Cessation
- 1975-03-20 CH CH355075A patent/CH602641A5/xx not_active IP Right Cessation
- 1975-03-20 FR FR7509371A patent/FR2264530A1/en active Granted
- 1975-03-21 NL NL7503417.A patent/NL159660B/en not_active IP Right Cessation
- 1975-03-22 JP JP7534871A patent/JPS584019B2/en not_active Expired
-
1978
- 1978-11-14 KE KE2900A patent/KE2900A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES435753A1 (en) | 1977-04-01 |
| NO144108B (en) | 1981-03-16 |
| FI750825A7 (en) | 1975-09-22 |
| SE427750B (en) | 1983-05-02 |
| DK147854B (en) | 1984-12-24 |
| JPS50129573A (en) | 1975-10-13 |
| NO750957L (en) | 1975-09-23 |
| NL7503417A (en) | 1975-09-23 |
| JPS584019B2 (en) | 1983-01-24 |
| ES435755A1 (en) | 1977-04-01 |
| CH602641A5 (en) | 1978-07-31 |
| NO144108C (en) | 1981-06-24 |
| SE7503196L (en) | 1975-09-22 |
| FI60200B (en) | 1981-08-31 |
| FR2264530B1 (en) | 1978-11-10 |
| FR2264530A1 (en) | 1975-10-17 |
| ES435757A1 (en) | 1977-04-01 |
| NL159660B (en) | 1979-03-15 |
| ES435754A1 (en) | 1977-04-01 |
| FI60200C (en) | 1981-12-10 |
| DK147854C (en) | 1985-07-22 |
| KE2900A (en) | 1978-12-01 |
| DK117675A (en) | 1975-09-22 |
| AR216043A1 (en) | 1979-11-30 |
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