ES423978A1 - PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. - Google Patents

Abstract

Procedure for the preparation of new benzylamines of the general formula I, **(See formula)** where Hal signifies a chlorine or bromine atom, R1 signifies a hydrogen, chlorine or bromine atom, signifies the morpholinocarbonylmethyl radical, a branched alcohol radical with 3 to 5 carbon atoms optionally substituted with 1 to 3 hydroxyl groups, or a group of the formula **(See formula)** where R3 signifies a hydrogen atom, a hydroxy group or an alcohol group with 1 to 4 carbon atoms, n signifies the numbers 0, 1 or 2 and the two radicals A and B signify hydrogen atoms or together the group **(See formula)** where R5 represents a hydrogen atom or a lower alcohol radical with 1 or 2 carbon atoms and m means the numbers 1 or 2, means a straight chain or branched alcohol radical with 1 to 4 carbon atoms, an alkenyl radical with 2 to 4 carbon atoms, a cycloalkyl radical with 3 or 4 carbon atoms or also a hydrogen atom, if R3 does not represent any hydrogen atom or R2 represents a branched alcohol radical with 3 to 5 carbon atoms, possibly substituted by 1 to 3 hydroxyl groups, and l means the numbers 1 or 2, as well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of the general formula II is reacted **(See formula)** wherein R1, Hal and l are as initially defined and signify an alcoholic, aryl or aralcohyl radical, with an amine of the general formula III, **(See formula)** wherein R2 and R4 are as initially defined and thereafter the reaction product obtained is hydrolyzed; and a compound of the general formula I, obtained according to the procedure, is subsequently transformed, if desired, into its physiologically compatible salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)