ES423746A1 - Procedure for preparing 2-aminoindane derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparing 2-aminoindane derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES423746A1 ES423746A1 ES423746A ES423746A ES423746A1 ES 423746 A1 ES423746 A1 ES 423746A1 ES 423746 A ES423746 A ES 423746A ES 423746 A ES423746 A ES 423746A ES 423746 A1 ES423746 A1 ES 423746A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- phenyl
- aminoindane
- procedure
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- LMHHFZAXSANGGM-UHFFFAOYSA-N 2-aminoindane Chemical class C1=CC=C2CC(N)CC2=C1 LMHHFZAXSANGGM-UHFFFAOYSA-N 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- MHVHCDLCLNXADJ-UHFFFAOYSA-N n-phenyl-2,3-dihydro-1h-inden-2-amine Chemical compound C1C2=CC=CC=C2CC1NC1=CC=CC=C1 MHVHCDLCLNXADJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for preparing 2-aminoindane derivatives of formula: **(See formula)** where n is equal to 2 or 3, with the group (CH2) n having a straight or branched chain, R1 and R2 represent a lower alcohol radical containing 1 to 3 carbon atoms, where R1 and R2 can also form together with the atom of adjacent nitrogen a nitrogenous heterocyclic ring, A is an unsubstituted phenyl radical or a phenyl radical substituted with at least one substituent at the ortho, meta and/or para positions of the phenyl radical, and B represents hydrogen, an alkoxy radical containing 1 to 3 carbon atoms, or a group of the formula (see formula), where R3 and R4, which may be identical or different, represent an alcoholic or lower hydroxyalkyl radical, where R3 can also represent hydrogen, while R3 and R4 can also form a heterocyclic ring with the attached nitrogen atom Nitrogen, as well as the acid addition salts of said compounds, said procedure comprising the following steps: reacting an N-phenyl-2-aminoindane of the formula: **(See formula)** with a bromo-chloroalkane of the formula: Br- (CH2) n-Cl (III) to obtain an intermediate product, that is, an N-phenyl-N-chloroalcoMl-2-aminoindane of formula: **(See formula)** and reacting the N-phenyl-N-chloroalcohyl-2-aminoindane of formula (IV) with an amine of the following formula: **(See formula)** n, R1, R2, A and B having the above meanings in formula (II), (III), (IV) and (V), and if desired, converting the compound of formula I obtained into an addition salt of acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB998773*[A GB1405444A (en) | 1972-09-18 | 1973-03-01 | 2-aminoindane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES423746A1 true ES423746A1 (en) | 1976-05-01 |
Family
ID=9882457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES423746A Expired ES423746A1 (en) | 1973-03-01 | 1974-02-28 | Procedure for preparing 2-aminoindane derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5029541A (en) |
| AR (1) | AR208282A1 (en) |
| AT (1) | AT330166B (en) |
| CA (1) | CA997765A (en) |
| CH (1) | CH587796A5 (en) |
| DD (1) | DD110649A5 (en) |
| ES (1) | ES423746A1 (en) |
| HU (1) | HU167911B (en) |
| IL (1) | IL44291A (en) |
| LU (1) | LU69495A1 (en) |
| NL (1) | NL7402731A (en) |
| ZA (1) | ZA741196B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7718674B2 (en) | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
| WO2008011161A2 (en) | 2006-07-21 | 2008-01-24 | Bridge Pharma, Inc. | Dermal anesthetic compounds |
| TWI603957B (en) * | 2012-08-15 | 2017-11-01 | 阿沙納生物科學有限責任公司 | Use of aminoindane compounds in treating overactive bladder and interstitial cystitis |
-
1974
- 1974-01-01 AR AR252560A patent/AR208282A1/en active
- 1974-02-22 ZA ZA00741196A patent/ZA741196B/en unknown
- 1974-02-26 JP JP49022702A patent/JPS5029541A/ja active Pending
- 1974-02-26 IL IL44291A patent/IL44291A/en unknown
- 1974-02-27 LU LU69495A patent/LU69495A1/xx unknown
- 1974-02-28 CA CA193,775A patent/CA997765A/en not_active Expired
- 1974-02-28 HU HUCI1457A patent/HU167911B/hu unknown
- 1974-02-28 CH CH283674A patent/CH587796A5/en not_active IP Right Cessation
- 1974-02-28 NL NL7402731A patent/NL7402731A/xx not_active Application Discontinuation
- 1974-02-28 ES ES423746A patent/ES423746A1/en not_active Expired
- 1974-02-28 DD DD176870A patent/DD110649A5/xx unknown
- 1974-03-01 AT AT170474A patent/AT330166B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5029541A (en) | 1975-03-25 |
| NL7402731A (en) | 1974-09-03 |
| ZA741196B (en) | 1975-01-29 |
| HU167911B (en) | 1976-01-28 |
| CH587796A5 (en) | 1977-05-13 |
| ATA170474A (en) | 1975-09-15 |
| AT330166B (en) | 1976-06-25 |
| AR208282A1 (en) | 1976-12-20 |
| IL44291A (en) | 1977-03-31 |
| DD110649A5 (en) | 1975-01-05 |
| LU69495A1 (en) | 1974-06-05 |
| AU6607374A (en) | 1975-08-28 |
| CA997765A (en) | 1976-09-28 |
| IL44291A0 (en) | 1974-05-16 |
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