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ES421098A1 - Fluoro-substituted thiaxanthene derivatives - Google Patents

Fluoro-substituted thiaxanthene derivatives

Info

Publication number
ES421098A1
ES421098A1 ES421098A ES421098A ES421098A1 ES 421098 A1 ES421098 A1 ES 421098A1 ES 421098 A ES421098 A ES 421098A ES 421098 A ES421098 A ES 421098A ES 421098 A1 ES421098 A1 ES 421098A1
Authority
ES
Spain
Prior art keywords
formula
see formula
compound
see
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES421098A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
Kefalas AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kefalas AS filed Critical Kefalas AS
Publication of ES421098A1 publication Critical patent/ES421098A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A method for the preparation of fluorine-substituted thiaxanthenes of the formula **(See formula)** where X is (see formula) or (see formula) and Y (see formula) or (see formula), where Ac is an acyl radical or an aliphatic carboxylic acid having from one to 17 carbon atoms, inclusive, and their acid addition salts, characterized in that it comprises reacting a compound of the formula: **(See formula)** where X is as previously defined, with an amine of the formula **(See formula)** where Y is as previously defined, at elevated temperatures to obtain a compound of formula I, and isolating the compound of formula I as the free base or its non-toxic acid addition salt, and if desired, esterifying any group hydroxy present with a reactive derivative of an aliphatic carboxylic acid having 1 to 17 carbon atoms inclusive, and if desired, separating its individual isomers in a conventional manner. (Machine-translation by Google Translate, not legally binding)
ES421098A 1972-12-08 1973-12-03 Fluoro-substituted thiaxanthene derivatives Expired ES421098A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5691072A GB1453828A (en) 1972-12-08 1972-12-08 Fluoro-substituted thiaxanthene derivatives

Publications (1)

Publication Number Publication Date
ES421098A1 true ES421098A1 (en) 1976-08-01

Family

ID=10477876

Family Applications (2)

Application Number Title Priority Date Filing Date
ES421098A Expired ES421098A1 (en) 1972-12-08 1973-12-03 Fluoro-substituted thiaxanthene derivatives
ES444294A Expired ES444294A1 (en) 1972-12-08 1976-01-14 Fluoro-substituted thiaxanthene derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES444294A Expired ES444294A1 (en) 1972-12-08 1976-01-14 Fluoro-substituted thiaxanthene derivatives

Country Status (19)

Country Link
JP (1) JPS594436B2 (en)
AR (2) AR202805A1 (en)
AT (1) AT332395B (en)
BE (1) BE808347A (en)
CH (2) CH592085A5 (en)
CS (1) CS176259B2 (en)
DE (1) DE2359359C3 (en)
DK (1) DK145576C (en)
ES (2) ES421098A1 (en)
FI (1) FI57410C (en)
FR (1) FR2209573B1 (en)
GB (1) GB1453828A (en)
HU (1) HU167778B (en)
IE (1) IE38554B1 (en)
NL (1) NL7316035A (en)
NO (1) NO138806C (en)
PL (1) PL95266B1 (en)
SE (1) SE400287B (en)
ZA (1) ZA738990B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ189108A (en) * 1977-12-29 1982-02-23 Kefalas As 2-methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene and pharmaceutical compositions intermediate 2-methylthio-6-fluoro-9-(1-methyl-4-piperidyl)-thioxanthen-9-ol
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
GB8628903D0 (en) * 1986-12-03 1987-01-07 Lunbeck A S H Neuroleptic compounds
US6127385A (en) * 1999-03-04 2000-10-03 Pharmaquest Limited Method of treating depression using l-threo-methylphenidate
US6395752B1 (en) * 1999-03-04 2002-05-28 Pharmaquest Limited Method of treating depression using 1-threo-methylphenidate
WO2008080398A1 (en) * 2007-01-05 2008-07-10 Bkg Pharma Aps Anti - infective agents such as phenothiazine and thioxanthene derivates to treat infectious diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE585338A (en) * 1958-12-04
FR1463787A (en) * 1963-10-14 1966-07-22 Pfizer & Co C Aminoalkyl-trisubstituted phosphonium compounds, derivatives of such compounds, and processes for their preparation

Also Published As

Publication number Publication date
IE38554L (en) 1974-06-08
JPS594436B2 (en) 1984-01-30
DE2359359C3 (en) 1978-11-02
AR202805A1 (en) 1975-07-24
BE808347A (en) 1974-03-29
DK145576B (en) 1982-12-13
NL7316035A (en) 1974-06-11
ATA1000373A (en) 1976-01-15
PL95266B1 (en) 1977-10-31
CS176259B2 (en) 1977-06-30
FI57410B (en) 1980-04-30
ES444294A1 (en) 1977-10-01
NO138806B (en) 1978-08-07
FI57410C (en) 1980-08-11
SE400287B (en) 1978-03-20
CH592085A5 (en) 1977-10-14
DE2359359B2 (en) 1978-02-16
AT332395B (en) 1976-09-27
HU167778B (en) 1975-12-25
DE2359359A1 (en) 1974-06-27
IE38554B1 (en) 1978-04-12
DK145576C (en) 1983-06-13
FR2209573A1 (en) 1974-07-05
JPS4994691A (en) 1974-09-09
FR2209573B1 (en) 1977-12-09
NO138806C (en) 1978-11-15
AU6296673A (en) 1975-05-29
CH590272A5 (en) 1977-07-29
GB1453828A (en) 1976-10-27
ZA738990B (en) 1974-11-27
AR202672A1 (en) 1975-06-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19850211