ES428622A1 - Procedure for obtaining derivatives of 1,4-benzodiazepina. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for obtaining derivatives of 1,4-benzodiazepina. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES428622A1 ES428622A1 ES428622A ES428622A ES428622A1 ES 428622 A1 ES428622 A1 ES 428622A1 ES 428622 A ES428622 A ES 428622A ES 428622 A ES428622 A ES 428622A ES 428622 A1 ES428622 A1 ES 428622A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- translation
- morpholino
- procedure
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 2-pyridinium Chemical group 0.000 abstract 7
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical class OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000004658 ketimines Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 230000002269 spontaneous effect Effects 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procedure for obtaining 1,4-benzodiazepine derivatives, characterized essentially by obtaining compounds of general formula I: **(See formula)** where R1 is hydrogen, methyl, chlorine, bromine or nitro, R2 is cyclohexyl, 2-pyridinium, phenyl unsubstituted or substituted by fluorine or chlorine in position 2, R3 is hydrogen or methyl and is methyl, ethyl, 2-morpholinoethyl, 2-dimethyl-amino-ethyl, 2-diethylamino-propyl, 2-piperidinoethyl, 6-morpholino-n-hexyl, 4-morpholino-n-butyl or 3-morpholino-propyl, and characterized by the reaction of the compounds of general formula II: **(See formula)** with derivatives of malonic acid whose general structure is III **(See formula)** where X and Y are the same or different halogen atoms, preferably chlorine and bromine, followed by spontaneous cyclization, in the same reaction medium, of the resulting ketimine IV: **(See formula)** to give the compounds of formula I. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES428622A ES428622A1 (en) | 1974-07-24 | 1974-07-24 | Procedure for obtaining derivatives of 1,4-benzodiazepina. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES428622A ES428622A1 (en) | 1974-07-24 | 1974-07-24 | Procedure for obtaining derivatives of 1,4-benzodiazepina. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES428622A1 true ES428622A1 (en) | 1976-08-16 |
Family
ID=8467256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES428622A Expired ES428622A1 (en) | 1974-07-24 | 1974-07-24 | Procedure for obtaining derivatives of 1,4-benzodiazepina. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES428622A1 (en) |
-
1974
- 1974-07-24 ES ES428622A patent/ES428622A1/en not_active Expired
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