ES425303A1 - Un procedimiento de fabricacion de sales de heparina sim- ples. - Google Patents
Un procedimiento de fabricacion de sales de heparina sim- ples.Info
- Publication number
- ES425303A1 ES425303A1 ES425303A ES425303A ES425303A1 ES 425303 A1 ES425303 A1 ES 425303A1 ES 425303 A ES425303 A ES 425303A ES 425303 A ES425303 A ES 425303A ES 425303 A1 ES425303 A1 ES 425303A1
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- sodium
- salt
- mixed
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 5
- 229910052708 sodium Inorganic materials 0.000 abstract 5
- 239000011734 sodium Substances 0.000 abstract 5
- 229920000669 heparin Polymers 0.000 abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229960002897 heparin Drugs 0.000 abstract 2
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- -1 optionally Chemical class 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UN procedimiento de fabricación de sales de heparina simples que contienen cationes metálicos distinto del sodio, o sales de heparina mixtas, que comprende, en una primera fase, una puesta en contacto de una sal simple inicial de la heparina con una sal del metal que se desea sustituya al contenido en el heparinato inicial, caracterizado por el hecho de que se procede a continuación, en una segunda fase, al menos una vez, al ciclo de operaciones que comprenden la separación de los iones metálicos libres del heparinato obtenido, y la nueva puesta en contacto del heparinato obtenido con la sal que contiene el metal de sustitución
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7313581A FR2225149A1 (en) | 1973-04-13 | 1973-04-13 | Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects |
| FR7313580A FR2225406A1 (en) | 1973-04-13 | 1973-04-13 | Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES425303A1 true ES425303A1 (es) | 1976-12-16 |
Family
ID=26217686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES425303A Expired ES425303A1 (es) | 1973-04-13 | 1974-04-13 | Un procedimiento de fabricacion de sales de heparina sim- ples. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4168377A (es) |
| JP (1) | JPS5052217A (es) |
| AR (1) | AR210456A1 (es) |
| AU (1) | AU504218B2 (es) |
| BE (1) | BE813707A (es) |
| CA (1) | CA1042001A (es) |
| CH (1) | CH597259A5 (es) |
| DE (1) | DE2417859C2 (es) |
| ES (1) | ES425303A1 (es) |
| GB (1) | GB1471482A (es) |
| IT (1) | IT1100950B (es) |
| NL (1) | NL7405033A (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110878129A (zh) * | 2019-12-06 | 2020-03-13 | 中国科学院烟台海岸带研究所 | 一种氨基葡萄糖肝素盐及其应用 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2400036A1 (fr) * | 1977-08-08 | 1979-03-09 | Choay Sa | Heparines purifiees et leur preparation |
| SE449753B (sv) * | 1978-11-06 | 1987-05-18 | Choay Sa | Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav |
| US4500519A (en) * | 1978-11-06 | 1985-02-19 | Choay S.A. | Mucopolysaccharides having biological properties, preparation and method of use |
| US4692435A (en) * | 1978-11-06 | 1987-09-08 | Choay, S.A. | Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation |
| FR2440376A1 (fr) * | 1978-11-06 | 1980-05-30 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
| IT1141263B (it) * | 1980-02-29 | 1986-10-01 | Italfarmaco Spa | Metodo per la preparazione di eparinato di calcio |
| US4405612A (en) * | 1980-05-23 | 1983-09-20 | Riker Laboratories, Inc. | Heparin web compositions |
| US4479799A (en) * | 1981-05-21 | 1984-10-30 | Riker Laboratories, Inc. | Hypodermic syringe containing microfibers of an amorphous heparin salt |
| SE8702254D0 (sv) * | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | Novel heparin derivatives |
| US20050090662A1 (en) * | 1997-01-15 | 2005-04-28 | Beavers Ellington M. | Method of making free acids from polysaccharide salts |
| US6969705B2 (en) | 2000-07-21 | 2005-11-29 | Aventis Pharma S.A. | Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
| US20040171819A1 (en) * | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
| US7956046B2 (en) * | 2003-07-24 | 2011-06-07 | Aventis Pharma S.A. | Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them |
| CN105218704A (zh) * | 2015-09-29 | 2016-01-06 | 山东绅联生物科技有限公司 | 一种肝素钙的制备方法 |
| EP3791884A1 (en) | 2019-09-16 | 2021-03-17 | Oskar Bunz | Combination of heparin and magnesium salt for the treatment of viral infections |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2623001A (en) * | 1949-04-07 | 1952-12-23 | Bengt E G V Sylven | Preparing heparin |
| US3192114A (en) * | 1952-06-21 | 1965-06-29 | Leo Ab | Preparations with protracted acth-effect |
| AT222807B (de) * | 1960-08-26 | 1962-08-10 | Fo We Forschungs Und Verwertun | Verfahren zur Herstellung eines therapeutisch wirksamen Produktes |
| US3482014A (en) * | 1966-06-29 | 1969-12-02 | Canada Packers Ltd | Orally active heparin and method for making and using same |
| US3506642A (en) * | 1967-07-03 | 1970-04-14 | Canada Packers Ltd | Stable orally active heparinoid complexes |
| FR1538204A (fr) * | 1967-09-27 | 1968-08-30 | Canada Packers Ltd | Dérivés de l'héparine et procédés pour leur préparation |
| FR6853M (es) * | 1967-12-08 | 1969-04-08 |
-
1974
- 1974-04-09 CA CA197,189A patent/CA1042001A/en not_active Expired
- 1974-04-10 US US05/459,712 patent/US4168377A/en not_active Expired - Lifetime
- 1974-04-10 AR AR253259A patent/AR210456A1/es active
- 1974-04-11 DE DE2417859A patent/DE2417859C2/de not_active Expired
- 1974-04-11 GB GB1620974A patent/GB1471482A/en not_active Expired
- 1974-04-11 CH CH511774A patent/CH597259A5/xx not_active IP Right Cessation
- 1974-04-11 NL NL7405033A patent/NL7405033A/xx not_active Application Discontinuation
- 1974-04-11 AU AU67836/74A patent/AU504218B2/en not_active Expired
- 1974-04-12 JP JP49040463A patent/JPS5052217A/ja active Pending
- 1974-04-12 BE BE143197A patent/BE813707A/xx not_active IP Right Cessation
- 1974-04-13 ES ES425303A patent/ES425303A1/es not_active Expired
-
1978
- 1978-11-27 IT IT30216/78A patent/IT1100950B/it active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110878129A (zh) * | 2019-12-06 | 2020-03-13 | 中国科学院烟台海岸带研究所 | 一种氨基葡萄糖肝素盐及其应用 |
| CN110878129B (zh) * | 2019-12-06 | 2022-02-01 | 中国科学院烟台海岸带研究所 | 一种氨基葡萄糖肝素盐及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU504218B2 (en) | 1979-10-04 |
| CH597259A5 (es) | 1978-03-31 |
| DE2417859C2 (de) | 1984-09-20 |
| JPS5052217A (es) | 1975-05-09 |
| AR210456A1 (es) | 1977-08-15 |
| NL7405033A (es) | 1974-10-15 |
| BE813707A (fr) | 1974-10-14 |
| DE2417859A1 (de) | 1974-10-24 |
| IT1100950B (it) | 1985-09-28 |
| US4168377A (en) | 1979-09-18 |
| GB1471482A (en) | 1977-04-27 |
| AU6783674A (en) | 1975-10-16 |
| IT7830216A0 (it) | 1978-11-27 |
| CA1042001A (en) | 1978-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES425303A1 (es) | Un procedimiento de fabricacion de sales de heparina sim- ples. | |
| PT78191A (en) | Process for preparing novel salts of omeprazole and of pharmaceutical compositions containing the same | |
| GB2094145B (en) | Stabilized insulin preparations and method for their production | |
| DE2965725D1 (en) | Biodegradable nanoparticles, pharmaceutical compositions containing them and process for their preparation | |
| PT83509A (en) | Process for the preparation of pharmaceutical compositions with controlled release of metoprolol | |
| IL47860A0 (en) | Novel 5,9 beta-disubstituted 2-tetrahydrofuryl-6,7-benzomorphans and their salts,their production and pharmaceutical compositions containing them | |
| ES447803A2 (es) | Procedimiento de obtencion de un activador del plasminogeno. | |
| ES475633A1 (es) | Procedimiento para la obtencion de derivados de 1-n-4,6-di-0-(aminoglicosil)-1,3-diamino-ciclitol. | |
| DE2963990D1 (en) | Analgesic tablet and process for its preparation | |
| IL51857A (en) | Bid-quaternary pyridinium-2-aldoxime salts,process for their preparation and pharmaceutical compositions containing them | |
| ES458967A1 (es) | Un procedimiento para la preparacion de una composicion de prostaglandina estabilizada. | |
| HU913011D0 (en) | Method for producing inhibitors of calcium ingestion | |
| ES8503512A1 (es) | Complejos de prostaglandinas | |
| IL43927A0 (en) | Lysino-calcium chloride and acid addition salts thereof,their preparation and pharmaceutical compositions containing them | |
| IL48352A (en) | 4-o-(2',6-diamino-2',3-,6'-tridesoxy a-dribohexopyranosyl)-6-o-(3''-methyl amino-3'',4'',6''-tridesoxy- ,d-xylohexopyranosyl)-2-desoxystreptamine and its salts,process for por preparing them and pharmaceutical compositions containing them | |
| ES486556A1 (es) | Procedimiento de preparacion de nuevos poli (h-) sulfatos derutina y sales de los mismos | |
| IL48189A (en) | Substituted iminodiacetic acids,process for their preparation,chelating agents containing said substituted iminodiacetic acids and pharmaceutical compositions for treatment of renal calcule containing them | |
| IL48208A (en) | L -fluoro-21-hydroxy-16 -methyl- 1,4,8-pregnatriene derivatives,process for their preparation and pharmaceutical compositions containing them | |
| IL47212A0 (en) | Cephalosporin derivatives,process for their preparation and pharmaceutical compositions containing them | |
| GB1492180A (en) | Pharmaceutical composition for the treatment of hyperammoniemia | |
| IL42865A (en) | Plant growth regulating compositions containing 2,3,4,6-di-o-aliphatylidene-a-lxylo-2-hexulofuranosonic acid derivatives,their preparation and some new such compounds | |
| GB1514838A (en) | Stable suspension of calcium-magnesium oxytetracycline for intrauterine administration in the treatment of bovine metritis | |
| ES425264A3 (es) | Procedimiento para la obtencion de un preparado de insuli- na. | |
| ES374950A2 (es) | Un procedimiento para la preparacion de beta-naftilacetami-dina. | |
| IL45759A0 (en) | Novel imidazopyrimidine derivatives,their production and pharmaceutical compositions containing them |