ES419264A1 - Thiosubstituted szetidinones and other antibiotic precursors - Google Patents
Thiosubstituted szetidinones and other antibiotic precursorsInfo
- Publication number
- ES419264A1 ES419264A1 ES419264A ES419264A ES419264A1 ES 419264 A1 ES419264 A1 ES 419264A1 ES 419264 A ES419264 A ES 419264A ES 419264 A ES419264 A ES 419264A ES 419264 A1 ES419264 A1 ES 419264A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- araliphatic
- aliphatic
- formula
- szetidinones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003115 biocidal effect Effects 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A procedure for the preparation of azetidin-2-one derivatives of general formula IV **(See formula)** where R1 is a blocked amino or amino group and R2a is a hydrogen atom or an aliphatic, araliphatic or aromatic group and R4 is an aliphatic, araliphatic, cycloaliphatic or aromatic hydrocarbyl group or an acyl group or R2a and R4 together form a group divalent hydrocarbyl, which comprises reacting a compound of formula I **(See formula)** (where R is hydrogen or the remainder of the 6-acylamino side chain of penicillin and R2 is a hydrogen atom or an aliphatic, araliphatic or aromatic group), with an S-etherifying or S-esterifying reagent. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5228670A GB1368234A (en) | 1970-11-03 | 1970-11-03 | Thiosubstituted szetidinones and other antibiotic precursors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES419264A1 true ES419264A1 (en) | 1976-11-01 |
Family
ID=10463345
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES393804A Expired ES393804A1 (en) | 1970-11-03 | 1971-07-30 | Thiosubstituted szetidinones and other antibiotic precursors |
| ES419264A Expired ES419264A1 (en) | 1970-11-03 | 1973-10-02 | Thiosubstituted szetidinones and other antibiotic precursors |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES393804A Expired ES393804A1 (en) | 1970-11-03 | 1971-07-30 | Thiosubstituted szetidinones and other antibiotic precursors |
Country Status (9)
| Country | Link |
|---|---|
| AU (1) | AU475747B2 (en) |
| BE (1) | BE770730A (en) |
| CH (2) | CH589622A5 (en) |
| DE (1) | DE2138320A1 (en) |
| ES (2) | ES393804A1 (en) |
| FR (1) | FR2112411B1 (en) |
| GB (1) | GB1368234A (en) |
| NL (1) | NL7110615A (en) |
| SE (1) | SE7414854L (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789021A (en) * | 1971-09-21 | 1973-03-20 | Glaxo Lab Ltd | PROCESS FOR PREPARING AZETIDIN-2-ONES |
| BE794659A (en) * | 1972-01-28 | 1973-07-30 | Glaxo Lab Ltd | PROCESS FOR PREPARING INTERMEDIATE COMPOUNDS FOR OBTAINING BETA-LACTAM TYPE ANTIBIOTICS |
| US4301278A (en) | 1974-02-26 | 1981-11-17 | Ciba-Geigy Corporation | Process for the manufacture of enol derivatives |
| US4147864A (en) | 1975-02-20 | 1979-04-03 | Ciba-Geigy Corporation | Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds |
| IT1058858B (en) | 1976-02-23 | 1982-05-10 | Snam Progetti | 5.6 DEHYDROPENICILLINS PROCESS FOR THEIR PREPARATION AND INTERMEDIATES OBTAINED IN THAT PROCESS |
| US4115383A (en) | 1976-02-23 | 1978-09-19 | Eli Lilly And Company | Alkoxycarbonyl-ethylthio-azetidinones and process for their preparation |
-
1970
- 1970-11-03 GB GB5228670A patent/GB1368234A/en not_active Expired
-
1971
- 1971-07-30 ES ES393804A patent/ES393804A1/en not_active Expired
- 1971-07-30 DE DE19712138320 patent/DE2138320A1/en not_active Withdrawn
- 1971-07-30 BE BE770730A patent/BE770730A/en unknown
- 1971-07-30 CH CH1129671A patent/CH589622A5/xx not_active IP Right Cessation
- 1971-07-30 FR FR7128116A patent/FR2112411B1/fr not_active Expired
- 1971-07-30 AU AU31846/71A patent/AU475747B2/en not_active Expired
- 1971-07-30 NL NL7110615A patent/NL7110615A/xx not_active Application Discontinuation
-
1973
- 1973-10-02 ES ES419264A patent/ES419264A1/en not_active Expired
-
1974
- 1974-11-26 SE SE7414854A patent/SE7414854L/xx unknown
-
1976
- 1976-03-22 CH CH1129671A patent/CH586675A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH589622A5 (en) | 1977-07-15 |
| NL7110615A (en) | 1972-05-05 |
| BE770730A (en) | 1972-01-31 |
| GB1368234A (en) | 1974-09-25 |
| AU475747B2 (en) | 1976-09-02 |
| AU3184671A (en) | 1973-02-01 |
| CH586675A5 (en) | 1977-04-15 |
| DE2138320A1 (en) | 1972-05-04 |
| SE7414854L (en) | 1974-11-26 |
| FR2112411B1 (en) | 1975-11-28 |
| FR2112411A1 (en) | 1972-06-16 |
| ES393804A1 (en) | 1974-07-16 |
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