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ES418014A1 - A PROCEDURE FOR PREPARING BENZODIAZEPINE DERIVATIVES. - Google Patents

A PROCEDURE FOR PREPARING BENZODIAZEPINE DERIVATIVES.

Info

Publication number
ES418014A1
ES418014A1 ES418014A ES418014A ES418014A1 ES 418014 A1 ES418014 A1 ES 418014A1 ES 418014 A ES418014 A ES 418014A ES 418014 A ES418014 A ES 418014A ES 418014 A1 ES418014 A1 ES 418014A1
Authority
ES
Spain
Prior art keywords
procedure
general formula
benzodiazepine derivatives
formula
indicated above
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES418014A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES418014A1 publication Critical patent/ES418014A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A procedure for preparing benzodiazepine derivatives of the general formula ** (See formula) ** in which R1 represents hydrogen, halogen, nitro or trifluorornetyl, R2 represents hydrogen or lower alkyl and R3 represents phenyl, o-halophenyl or 2-pyridyl, characterized by comprising reacting a compound of the general formula ** (See formula) ** in which R1, R2 and R3 have the meaning indicated above, and X represents chlorine, bromine or iodine, with hexamethylenetetramine in an inert organic solvent, with the possible isolation of an intermediate of the general formula ** (See formula) ** in which R1, R2, R3 X have the meaning indicated above, so ammonia is used in the procedure. (Machine-translation by Google Translate, not legally binding)
ES418014A 1972-08-21 1973-08-20 A PROCEDURE FOR PREPARING BENZODIAZEPINE DERIVATIVES. Expired ES418014A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28221772A 1972-08-21 1972-08-21
US35981473A 1973-05-14 1973-05-14

Publications (1)

Publication Number Publication Date
ES418014A1 true ES418014A1 (en) 1976-03-16

Family

ID=26961312

Family Applications (1)

Application Number Title Priority Date Filing Date
ES418014A Expired ES418014A1 (en) 1972-08-21 1973-08-20 A PROCEDURE FOR PREPARING BENZODIAZEPINE DERIVATIVES.

Country Status (24)

Country Link
JP (1) JPS5911589B2 (en)
AR (1) AR198108A1 (en)
AT (1) AT341527B (en)
AU (1) AU472777B2 (en)
CA (1) CA1012535A (en)
CH (1) CH578544A5 (en)
DD (1) DD107040A5 (en)
DE (1) DE2340159A1 (en)
DK (1) DK155326C (en)
ES (1) ES418014A1 (en)
FI (1) FI57939C (en)
FR (1) FR2197003B1 (en)
GB (1) GB1392681A (en)
HU (1) HU170153B (en)
IE (1) IE38091B1 (en)
IL (1) IL42947A (en)
LU (1) LU68269A1 (en)
NL (1) NL179582C (en)
NO (1) NO139481C (en)
PH (1) PH13640A (en)
PL (1) PL99162B1 (en)
SE (1) SE408302B (en)
SU (1) SU550980A3 (en)
YU (1) YU219873A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334792A (en) * 1976-09-13 1978-03-31 Scherico Ltd Production of 1*44 benzodiazepines and 1*44 benzodiazepinee22ones
RU2120441C1 (en) * 1996-10-18 1998-10-20 Олег Иванович Лукашов Method of preparing 7-bromo-1,3-dihydro-5-[2- chlorophenyl]-2h-1,4-benzdiazepin-2-one, 5-bromo-2-[2- chloroacetamido]-2′-clorobenzophenone
RU2150467C1 (en) * 1998-01-06 2000-06-10 Петрунин Александр Иванович Method of synthesis of 1,3-dihydro-7-nitro-5-phenyl-2h-1,4- -benzodiazepine-2-one (nitrazepam) (variants)
CN113149915B (en) * 2021-03-01 2024-03-15 中国科学院成都有机化学有限公司 Method for synthesizing clonazepam compound
CN116023342B (en) * 2021-10-26 2024-06-25 江苏昱林生物科技有限公司 Preparation method of high-purity clonazepam

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1136709B (en) * 1959-12-10 1962-09-20 Hoffmann La Roche Process for the preparation of 2-oxo-1, 2-dihydro-1, 4-benzodiazepines
CH537393A (en) * 1969-10-16 1973-05-31 Hoffmann La Roche Process for the preparation of 1,4-benzodiazepine derivatives
BE785962A (en) * 1971-07-08 1973-01-08 Hoffmann La Roche PROCESS FOR THE PREPARATION OF BENZODIAZEPINE DERIVATIVES

Also Published As

Publication number Publication date
PL99162B1 (en) 1978-06-30
AT341527B (en) 1978-02-10
HU170153B (en) 1977-04-28
ATA720773A (en) 1977-06-15
NO139481B (en) 1978-12-11
NO139481C (en) 1979-03-21
CH578544A5 (en) 1976-08-13
FR2197003B1 (en) 1978-01-13
IE38091B1 (en) 1977-12-21
DE2340159A1 (en) 1974-03-07
JPS5911589B2 (en) 1984-03-16
LU68269A1 (en) 1975-05-21
IE38091L (en) 1974-02-21
IL42947A0 (en) 1973-11-28
NL7311507A (en) 1974-02-25
DD107040A5 (en) 1974-07-12
AU472777B2 (en) 1976-06-03
YU219873A (en) 1982-06-30
DK155326C (en) 1989-08-14
SU550980A3 (en) 1977-03-15
CA1012535A (en) 1977-06-21
PH13640A (en) 1980-08-18
AU5918073A (en) 1975-02-13
NL179582B (en) 1986-05-01
GB1392681A (en) 1975-04-30
DE2340159C2 (en) 1989-01-19
JPS4956992A (en) 1974-06-03
SE408302B (en) 1979-06-05
FI57939B (en) 1980-07-31
FR2197003A1 (en) 1974-03-22
NL179582C (en) 1986-10-01
FI57939C (en) 1980-11-10
DK155326B (en) 1989-03-28
AR198108A1 (en) 1974-05-31
IL42947A (en) 1977-01-31

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