ES417461A1 - 6-alpha-amidino-and imidoylaminoalkanoyl-amino-penicillanic acids - Google Patents
6-alpha-amidino-and imidoylaminoalkanoyl-amino-penicillanic acidsInfo
- Publication number
- ES417461A1 ES417461A1 ES417461A ES417461A ES417461A1 ES 417461 A1 ES417461 A1 ES 417461A1 ES 417461 A ES417461 A ES 417461A ES 417461 A ES417461 A ES 417461A ES 417461 A1 ES417461 A1 ES 417461A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- thienyl
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 150000001447 alkali salts Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- -1 pyrrile Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure for preparing a compound of the formula: **(See formula)** and the pharmaceutically acceptable basic salts thereof wherein Ar is phenyl, 4-hydroxyphenyl, 2-thienyl, or 3-thienyl: Z is **(See formula)** where A is 1,4-phenylene, alkylene containing 1 to 3 carbon atoms, or alkylidene containing 2 to 3 carbon atoms; R1 and R2 when considered separately, each is hydrogen or alkyl containing 1 to 3 carbon atoms; R1 and R4 each are hydrogen, alkyl containing 1 to 3 carbon atoms, naphthyl, thienyl, pyrrile, furyl, pyridyl, phenyl, benzyl, substituted phenyl or substituted benzyl where the substituent is chlorine, bromine, fluorine, methyl, methoxy, trifluomethyl, 3,4-dichloro or 3,5-dichloro; R1 and R2 when considered together are alkylene containing from 2 to 6 carbon atoms; R1 and R2 when considered together are alkylene containing from 2 to 4 carbon atoms; and R2 and R4 when considered together are alkylene containing from 3 to 5 carbon atoms, characterized by react a compound of the formula **(See formula)** or a salt thereof, with a compound of the formula Z-X where Z is as defined above, and X is -OH or Cl in the presence of a cleaner to remove the elements from the water or HCl, respectively, and if desired, form the pharmaceutically acceptable basic salts thereof. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27706472A | 1972-08-02 | 1972-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES417461A1 true ES417461A1 (en) | 1976-03-01 |
Family
ID=23059254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES417461A Expired ES417461A1 (en) | 1972-08-02 | 1973-08-01 | 6-alpha-amidino-and imidoylaminoalkanoyl-amino-penicillanic acids |
Country Status (30)
| Country | Link |
|---|---|
| JP (1) | JPS5318039B2 (en) |
| AR (1) | AR206879A1 (en) |
| AT (1) | AT327382B (en) |
| AU (1) | AU472676B2 (en) |
| BE (1) | BE803094A (en) |
| BG (1) | BG25798A3 (en) |
| CA (1) | CA1015355A (en) |
| CH (1) | CH574447A5 (en) |
| CS (1) | CS168459B2 (en) |
| DD (1) | DD106849A5 (en) |
| DE (1) | DE2338389A1 (en) |
| DK (1) | DK137047B (en) |
| EG (1) | EG10896A (en) |
| ES (1) | ES417461A1 (en) |
| FI (1) | FI56840C (en) |
| FR (1) | FR2194415B1 (en) |
| GB (1) | GB1418656A (en) |
| HU (1) | HU167653B (en) |
| IE (1) | IE37961B1 (en) |
| IL (1) | IL42820A (en) |
| LU (1) | LU68143A1 (en) |
| NL (1) | NL7310696A (en) |
| NO (1) | NO144831C (en) |
| PH (1) | PH12770A (en) |
| PL (1) | PL96500B1 (en) |
| RO (2) | RO68719A2 (en) |
| SE (1) | SE415977B (en) |
| SU (2) | SU576944A3 (en) |
| YU (1) | YU36966B (en) |
| ZA (1) | ZA735236B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024130A (en) * | 1975-03-31 | 1977-05-17 | Pfizer Inc. | Process for the manufacture of alkali metal salts of 6-[2-phenyl-2-(imidoylaminoalkanoylamino)acetamido]penicillanic acids |
| US4073780A (en) * | 1976-06-03 | 1978-02-14 | Pfizer Inc. | 4-Pyridylformimidoylglycyl-D-phenylglycine |
-
1972
- 1972-12-27 GB GB5971172A patent/GB1418656A/en not_active Expired
-
1973
- 1973-01-01 AR AR249414A patent/AR206879A1/en active
- 1973-07-09 SE SE7309644A patent/SE415977B/en unknown
- 1973-07-24 AU AU58433/73A patent/AU472676B2/en not_active Expired
- 1973-07-25 IL IL42820A patent/IL42820A/en unknown
- 1973-07-28 DE DE19732338389 patent/DE2338389A1/en not_active Withdrawn
- 1973-07-31 FI FI2405/73A patent/FI56840C/en active
- 1973-07-31 IE IE1303/73A patent/IE37961B1/en unknown
- 1973-07-31 FR FR7327954A patent/FR2194415B1/fr not_active Expired
- 1973-07-31 CA CA177,719A patent/CA1015355A/en not_active Expired
- 1973-08-01 HU HUPI392A patent/HU167653B/hu unknown
- 1973-08-01 NO NO3091/73A patent/NO144831C/en unknown
- 1973-08-01 BE BE1005272A patent/BE803094A/en not_active IP Right Cessation
- 1973-08-01 ES ES417461A patent/ES417461A1/en not_active Expired
- 1973-08-01 ZA ZA735236A patent/ZA735236B/en unknown
- 1973-08-01 DD DD172673A patent/DD106849A5/xx unknown
- 1973-08-01 DK DK422873AA patent/DK137047B/en not_active IP Right Cessation
- 1973-08-01 SU SU7301949310A patent/SU576944A3/en active
- 1973-08-01 YU YU2086/73A patent/YU36966B/en unknown
- 1973-08-02 NL NL7310696A patent/NL7310696A/xx not_active Application Discontinuation
- 1973-08-02 BG BG024251A patent/BG25798A3/en unknown
- 1973-08-02 AT AT680773A patent/AT327382B/en active
- 1973-08-02 LU LU68143A patent/LU68143A1/xx unknown
- 1973-08-02 PL PL1973164483A patent/PL96500B1/en unknown
- 1973-08-02 EG EG298/73A patent/EG10896A/en active
- 1973-08-02 CH CH1124373A patent/CH574447A5/xx not_active IP Right Cessation
- 1973-08-02 RO RO7387460A patent/RO68719A2/en unknown
- 1973-08-02 CS CS5498A patent/CS168459B2/cs unknown
- 1973-08-02 JP JP8646073A patent/JPS5318039B2/ja not_active Expired
- 1973-08-02 RO RO7300075697A patent/RO63748A/en unknown
-
1975
- 1975-10-16 PH PH17666A patent/PH12770A/en unknown
- 1975-11-03 SU SU7502185959A patent/SU576945A3/en active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE37226L (en) | Piperidine derivatives. | |
| ES410729A1 (en) | Substituted piperidinoalkanone oxime derivatives | |
| ES425626A1 (en) | Acylxylidide local anaesthetics | |
| ES410731A1 (en) | Alpha-aryl-4-substituted piperidinoalkanol derivatives | |
| ES456610A1 (en) | Therapeutic sulfonamides | |
| KR900011728A (en) | Substituted indole, benzofuran and benzothiophene derivatives as 5-lipoxygenase inhibitors | |
| ES325271A1 (en) | Procedure for the preparation of new substitute phenylacetic acids (Machine-translation by Google Translate, not legally binding) | |
| ES417461A1 (en) | 6-alpha-amidino-and imidoylaminoalkanoyl-amino-penicillanic acids | |
| ES457993A1 (en) | Isothiazolo-pyridines | |
| ES413937A1 (en) | A PROCEDURE FOR PREPARING 6 - (2 - ARIL - 2 - 3 (3 - GUANIL - 1 - UREIDOALKANOILAMINO) ACETAMIDO) PENECILANICO. | |
| ES446126A1 (en) | 2-(phenoxyalkylthio)imidazoles and congeners | |
| ES436624A1 (en) | Pyrimidones | |
| ES410855A1 (en) | PROCEDURE FOR OBTAINING BENZOCYCLO-HEPTATIOPHENE DERIVATIVES. | |
| ES396415A1 (en) | A procedure for the preparation of polyarimimidazoles. (Machine-translation by Google Translate, not legally binding) | |
| ES428442A1 (en) | 1,2,3,4-tetrahydroisoquinoline derivatives and the preparation thereof | |
| JPS5318581A (en) | Novel o-nitrobutyrophenone derivatives | |
| JPS5481260A (en) | 2-4-(3-methyl-2-thienyl)phenyl propionic acid, its nontoxic salt and antiphlogistics, analgesics, and antirheumatics containing them | |
| ES381429A1 (en) | Penicillins | |
| GB1417745A (en) | Chromene compounds | |
| PT70956A (en) | NEW PENICILLINES, THEIR SALTS METHOD FOR THE PRODUCTION THEREOF, AND THE MEDICAMENTS CONTAINING THESE COMPOUNDS | |
| ES426949A1 (en) | Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding) | |
| ES399607A1 (en) | A procedure for preparing N-tienyl alcohil - beta - alcoxitrifluoro-metifenol-cohilaminas. (Machine-translation by Google Translate, not legally binding) | |
| ES450207A1 (en) | A procedure for the preparation of new salts of 4,5dihidro-2-alcoxicarbonil-amino-4-aril-imidazoles. (Machine-translation by Google Translate, not legally binding) | |
| GB1057969A (en) | Aryloxyamines and process for preparation | |
| ES362645A2 (en) | A procedure for the preparation of penicillins. (Machine-translation by Google Translate, not legally binding) |