ES416815A1 - Benzodiazepine derivatives - Google Patents

Abstract

A method for preparing benzodiazepine derivatives constituting the active substance in pharmacological compositions with anticonvulsant, muscle relaxant and sedative properties of the general formula **(See formula)** in which Y represents one of the groups **(See formula)** R, R1 and R2 represent hydrogen or lower alkyl, R3 represents phenyl, halophanyl, dihalophenyl or pyridyl, R4 represents hydrogen, lower alkyl, hydroxy or lower alkanoyloxy, R5 and R6 represent any molecular fraction capable of being easily eliminated by traditional hydrolyzing techniques and n represents the integer 0 or 1 with the exception that n represents the integer 0 when R4 represents hydroxyl or lower alkanoyloxy, and its pharmaceutically acceptable acid addition salts, characterized in that when said compounds of the general formula, present the structure **(See formula)** in which Z represents the group **(See formula)** and n, R, R1, R2, R3, R4, R5 and R6 have the meaning indicated above, in which R7 represents lower alkyl and n, Z, R, R1, R3, R4, R5, and R6 have the meaning indicated above, with a lower alkanoyl hydrazide, and if desired, in a second phase, a compound of the general formula is hydrolyzed **(See formula)** previously obtained, where n, R, R2, R3, R4, R5 and R6 have the meaning indicated above, to achieve the compounds of the general formula in which n, R, R2, R3 and R4 also have the previously defined meaning, and in a third phase, the compound of formula Ib above is reduced, to constitute the compounds of the general formula **(See formula)** in which n, R, R2, R3 and R4 have the meaning already indicated. (Machine-translation by Google Translate, not legally binding)