ES401033A1 - Water-soluble iodomethane sulphonamide useful as non-ionic x-ray contrast compounds and process for their production - Google Patents
Water-soluble iodomethane sulphonamide useful as non-ionic x-ray contrast compounds and process for their productionInfo
- Publication number
- ES401033A1 ES401033A1 ES401033A ES401033A ES401033A1 ES 401033 A1 ES401033 A1 ES 401033A1 ES 401033 A ES401033 A ES 401033A ES 401033 A ES401033 A ES 401033A ES 401033 A1 ES401033 A1 ES 401033A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- soluble
- formula
- water
- ray contrast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FDGDRDDFTVNCGU-UHFFFAOYSA-N iodomethanesulfonamide Chemical compound NS(=O)(=O)CI FDGDRDDFTVNCGU-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- -1 β-hydroxyethyl Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- RDFJFVXMRYVOAC-UHFFFAOYSA-N methiodal Chemical class OS(=O)(=O)CI RDFJFVXMRYVOAC-UHFFFAOYSA-N 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedure for the preparation of new iodomethanesulfonamides easily soluble in water capable of being used as shadow-supplying components in X-ray contrast agents, of the general formula I **(See formula)** wherein R preferably stands for hydrogen or also the methyl group and stands for the group β-hydroxyethyl, β- (β'-hydroxyethoxy) -ethyl, β, γ -dihydroxypropyl, or α, γ -dihydroxyisopropyl, characterized in that react a reactive iodomethanesulfonic acid derivative of the general formula: I-CH2-SO2-x with a reactive compound of the formula Y-R1' where X and Y are reactive radicals that form the group **(See formula)** and one of the symbols X and Y represents a halogen, chlorine, bromine or iodine radical, or an alcohol-sulfonyloxy- or arylsulfonyloxy radical and the other represents a group (see formula), in which R means hydrogen or methyl R'1 means the group β-hydroxyethyl, β- (β-hydroxyethoxy) -ethyl, β, γ -dihydroxypropyl, or α, γ -dihydroxyisopropyl, and may be masked hydroxyl functions by means of protecting groups, which can be easily separated by careful hydrolysis or hydrogenolysis, and by isolating the desired water-soluble iodomethanesulfonic acid amide, if necessary with release of the protected hydroxyl functions during main reaction by hydrolysis or selective hydrogenolysis. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH431771*[A CH550003A (en) | 1971-03-23 | 1971-03-23 | N-hydroxyalkyl-iodomethanesulphonamides - which are non-ionogenic water-soluble radiopaque substances |
| CH1674671 | 1971-11-17 | ||
| CH1674771 | 1971-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES401033A1 true ES401033A1 (en) | 1972-10-16 |
Family
ID=27174801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES401033A Expired ES401033A1 (en) | 1971-03-23 | 1972-03-21 | Water-soluble iodomethane sulphonamide useful as non-ionic x-ray contrast compounds and process for their production |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5113128B1 (en) |
| AR (2) | AR194119A1 (en) |
| BE (1) | BE780901A (en) |
| CA (1) | CA970390A (en) |
| DD (1) | DD96401A5 (en) |
| DE (1) | DE2201578A1 (en) |
| DK (1) | DK128109B (en) |
| ES (1) | ES401033A1 (en) |
| FR (1) | FR2130221B1 (en) |
| GB (1) | GB1359908A (en) |
| IL (1) | IL38909A (en) |
| NL (1) | NL7203414A (en) |
| SE (1) | SE380521B (en) |
| SU (1) | SU458128A3 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53145735U (en) * | 1977-04-23 | 1978-11-16 | ||
| US4304721A (en) | 1979-09-06 | 1981-12-08 | Hoffmann-La Roche Inc. | Adrenergic blocking agents |
| US5166431A (en) * | 1988-11-30 | 1992-11-24 | Elf Atochem North America, Inc. | Preparation of alkanesulfonamides |
| US4970339A (en) * | 1988-11-30 | 1990-11-13 | Atochem North America, Inc. | Preparation of alkanesulfonamides |
-
1972
- 1972-01-13 DE DE19722201578 patent/DE2201578A1/en active Pending
- 1972-02-08 CA CA134,236A patent/CA970390A/en not_active Expired
- 1972-02-25 SE SE7202353A patent/SE380521B/en unknown
- 1972-03-03 GB GB1006872A patent/GB1359908A/en not_active Expired
- 1972-03-06 IL IL38909A patent/IL38909A/en unknown
- 1972-03-10 JP JP47024053A patent/JPS5113128B1/ja active Pending
- 1972-03-14 FR FR7208869A patent/FR2130221B1/fr not_active Expired
- 1972-03-15 NL NL7203414A patent/NL7203414A/xx unknown
- 1972-03-17 BE BE780901A patent/BE780901A/en unknown
- 1972-03-21 ES ES401033A patent/ES401033A1/en not_active Expired
- 1972-03-22 SU SU1762976A patent/SU458128A3/en active
- 1972-03-22 DD DD161724A patent/DD96401A5/xx unknown
- 1972-03-22 DK DK136472AA patent/DK128109B/en unknown
- 1972-06-30 AR AR242856A patent/AR194119A1/en active
-
1973
- 1973-02-28 AR AR240739A patent/AR193638A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| SE380521B (en) | 1975-11-10 |
| SU458128A3 (en) | 1975-01-25 |
| IL38909A0 (en) | 1972-05-30 |
| JPS5113128B1 (en) | 1976-04-26 |
| BE780901A (en) | 1972-07-18 |
| DK128109B (en) | 1974-03-04 |
| DD96401A5 (en) | 1973-03-20 |
| FR2130221A1 (en) | 1972-11-03 |
| FR2130221B1 (en) | 1975-04-25 |
| NL7203414A (en) | 1972-09-26 |
| AR193638A1 (en) | 1973-05-11 |
| AR194119A1 (en) | 1973-06-22 |
| CA970390A (en) | 1975-07-01 |
| GB1359908A (en) | 1974-07-17 |
| DE2201578A1 (en) | 1972-10-05 |
| IL38909A (en) | 1974-12-31 |
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