ES396212A1 - Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos. - Google Patents
Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos.Info
- Publication number
- ES396212A1 ES396212A1 ES396212A ES396212A ES396212A1 ES 396212 A1 ES396212 A1 ES 396212A1 ES 396212 A ES396212 A ES 396212A ES 396212 A ES396212 A ES 396212A ES 396212 A1 ES396212 A1 ES 396212A1
- Authority
- ES
- Spain
- Prior art keywords
- ring
- bicyclic aryl
- racemic
- acid addition
- optically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000005877 1,4-benzodioxanyl group Chemical group 0.000 abstract 1
- -1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002366 halogen compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/56—Radicals substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2037852A DE2037852C3 (de) | 1970-07-30 | 1970-07-30 | Neue Piperazinderivate und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES396212A1 true ES396212A1 (es) | 1974-04-16 |
Family
ID=5778382
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES393738A Expired ES393738A1 (es) | 1970-07-30 | 1971-07-29 | Procedimiento para la preparacion de derivados de piperazi-na. |
| ES396212A Expired ES396212A1 (es) | 1970-07-30 | 1971-10-21 | Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos. |
| ES396215A Expired ES396215A1 (es) | 1970-07-30 | 1971-10-21 | Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos. |
| ES396216A Expired ES396216A1 (es) | 1970-07-30 | 1971-10-21 | Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos. |
| ES396214A Expired ES396214A1 (es) | 1970-07-30 | 1971-10-21 | Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos. |
| ES396213A Expired ES396213A1 (es) | 1970-07-30 | 1971-10-21 | Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES393738A Expired ES393738A1 (es) | 1970-07-30 | 1971-07-29 | Procedimiento para la preparacion de derivados de piperazi-na. |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES396215A Expired ES396215A1 (es) | 1970-07-30 | 1971-10-21 | Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos. |
| ES396216A Expired ES396216A1 (es) | 1970-07-30 | 1971-10-21 | Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos. |
| ES396214A Expired ES396214A1 (es) | 1970-07-30 | 1971-10-21 | Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos. |
| ES396213A Expired ES396213A1 (es) | 1970-07-30 | 1971-10-21 | Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3808212A (es) |
| JP (1) | JPS5716989B1 (es) |
| AT (6) | AT311976B (es) |
| AU (1) | AU463957B2 (es) |
| BE (1) | BE770800A (es) |
| BG (5) | BG19598A3 (es) |
| CH (6) | CH565165A5 (es) |
| CS (1) | CS172929B2 (es) |
| DE (1) | DE2037852C3 (es) |
| DK (1) | DK137990C (es) |
| ES (6) | ES393738A1 (es) |
| FR (1) | FR2100972B1 (es) |
| GB (1) | GB1344720A (es) |
| NL (1) | NL173643C (es) |
| PL (6) | PL84610B1 (es) |
| RO (6) | RO60596A (es) |
| SE (2) | SE375308B (es) |
| SU (4) | SU437290A3 (es) |
| YU (7) | YU34530B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940396A (en) * | 1973-02-28 | 1976-02-24 | Uniroyal Inc. | 1,2,3,4,4A,5,7,7A-Octahydrothieno[3,4-b]pyrazines 6,6-dioxides |
| US3991036A (en) * | 1973-02-28 | 1976-11-09 | Uniroyal Inc. | Preparation of polyurethane using 1,2,3,4,4a,5,7,7a-Octahydrothieno[3,4-b]py |
| GB1407552A (en) * | 1973-04-02 | 1975-09-24 | Science Union & Cie | Disubstituted piperazines processes for their preparation and pharmaceutical compositions containing them |
| GB1432660A (en) * | 1973-10-30 | 1976-04-22 | Science Union & Cie | Piperazine derivatives processes for their preparation and and pharamacueitcal compositions containing them |
| US3960863A (en) * | 1974-06-25 | 1976-06-01 | Sankyo Company Limited | Pyrido[1,2-a]pyrimidinone derivatives |
| DE2604838A1 (de) * | 1976-02-07 | 1977-08-11 | Knoll Ag | Alkylendioxypiperazinderivate |
| FI843507L (fi) * | 1983-01-21 | 1984-09-07 | Fisons Plc | Aromatiska aminer. |
| ATE44528T1 (de) * | 1984-12-21 | 1989-07-15 | Duphar Int Res | Arzneimittel mit antipsychotischer wirkung. |
| FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| CA2144669A1 (en) * | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Biphenyl derivatives |
| FR2734819B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant |
| US6002005A (en) * | 1995-06-02 | 1999-12-14 | Neurogen Corporation | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands |
| FR2737724B1 (fr) * | 1995-08-09 | 1997-09-05 | Synthelabo | Derives de 1-[2-(2,3-dihydro-1h-inden-1-yl)ethyl]-4- (naphtalen-1-yl) piperazine, leur preparation et leur application en therapeutique |
| JPH09124643A (ja) * | 1995-08-14 | 1997-05-13 | Bristol Myers Squibb Co | 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体 |
| US6040448A (en) * | 1997-10-24 | 2000-03-21 | Neurogen Corporation | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands |
| MA41169A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL132357C (es) * | 1966-09-03 |
-
1970
- 1970-07-30 DE DE2037852A patent/DE2037852C3/de not_active Expired
-
1971
- 1971-06-23 RO RO69217A patent/RO60596A/ro unknown
- 1971-06-23 RO RO69222A patent/RO60599A/ro unknown
- 1971-06-23 RO RO69219A patent/RO60597A/ro unknown
- 1971-06-23 RO RO67429A patent/RO59997A/ro unknown
- 1971-06-23 RO RO69218A patent/RO61040A/ro unknown
- 1971-06-23 RO RO69220A patent/RO60598A/ro unknown
- 1971-07-08 US US00160891A patent/US3808212A/en not_active Expired - Lifetime
- 1971-07-27 CH CH523875A patent/CH565165A5/xx not_active IP Right Cessation
- 1971-07-27 CH CH524275A patent/CH575412A5/xx not_active IP Right Cessation
- 1971-07-27 CH CH524075A patent/CH565166A5/xx not_active IP Right Cessation
- 1971-07-27 CH CH523975A patent/CH565781A5/xx not_active IP Right Cessation
- 1971-07-27 CH CH524175A patent/CH565167A5/xx not_active IP Right Cessation
- 1971-07-27 CH CH1106871A patent/CH565780A5/xx not_active IP Right Cessation
- 1971-07-28 BG BG21487A patent/BG19598A3/xx unknown
- 1971-07-28 BG BG018177A patent/BG21029A3/xx unknown
- 1971-07-28 JP JP5608071A patent/JPS5716989B1/ja active Pending
- 1971-07-28 BG BG021484A patent/BG20369A3/xx unknown
- 1971-07-28 BG BG21486A patent/BG20594A3/xx unknown
- 1971-07-28 SU SU1815878A patent/SU437290A3/ru active
- 1971-07-28 SU SU1688445A patent/SU416945A3/ru active
- 1971-07-28 CS CS5538A patent/CS172929B2/cs unknown
- 1971-07-28 BG BG021488A patent/BG20370A3/xx unknown
- 1971-07-28 SU SU1815881A patent/SU437292A3/ru active
- 1971-07-28 SU SU1815880A patent/SU437291A3/ru active
- 1971-07-29 YU YU1986/71A patent/YU34530B/xx unknown
- 1971-07-29 AT AT664271A patent/AT311976B/de active
- 1971-07-29 AT AT1100172A patent/AT311985B/de not_active IP Right Cessation
- 1971-07-29 AT AT1100472A patent/AT311988B/de active
- 1971-07-29 PL PL1971178481A patent/PL84610B1/pl unknown
- 1971-07-29 PL PL1971178479A patent/PL84348B1/pl unknown
- 1971-07-29 ES ES393738A patent/ES393738A1/es not_active Expired
- 1971-07-29 AT AT1100072A patent/AT311984B/de not_active IP Right Cessation
- 1971-07-29 PL PL1971149717A patent/PL84664B1/pl unknown
- 1971-07-29 AT AT1100272A patent/AT311986B/de not_active IP Right Cessation
- 1971-07-29 PL PL1971182554A patent/PL91965B1/pl unknown
- 1971-07-29 PL PL1971178480A patent/PL84347B1/pl unknown
- 1971-07-29 GB GB3577271A patent/GB1344720A/en not_active Expired
- 1971-07-29 AT AT1100372A patent/AT311987B/de active
- 1971-07-29 DK DK373271A patent/DK137990C/da active
- 1971-07-29 PL PL1971178478A patent/PL84349B1/pl unknown
- 1971-07-29 SE SE7109767A patent/SE375308B/xx unknown
- 1971-07-29 AU AU31772/71A patent/AU463957B2/en not_active Expired
- 1971-07-30 FR FR7128074A patent/FR2100972B1/fr not_active Expired
- 1971-07-30 BE BE770800A patent/BE770800A/xx not_active IP Right Cessation
- 1971-07-30 NL NLAANVRAGE7110538,A patent/NL173643C/xx not_active IP Right Cessation
- 1971-10-21 ES ES396212A patent/ES396212A1/es not_active Expired
- 1971-10-21 ES ES396215A patent/ES396215A1/es not_active Expired
- 1971-10-21 ES ES396216A patent/ES396216A1/es not_active Expired
- 1971-10-21 ES ES396214A patent/ES396214A1/es not_active Expired
- 1971-10-21 ES ES396213A patent/ES396213A1/es not_active Expired
-
1974
- 1974-06-27 SE SE7408533A patent/SE403288B/xx unknown
-
1978
- 1978-03-13 YU YU598/78A patent/YU34889B/xx unknown
- 1978-03-13 YU YU599/78A patent/YU34890B/xx unknown
- 1978-03-13 YU YU596/78A patent/YU34888B/xx unknown
- 1978-03-13 YU YU60078A patent/YU34891B/xx unknown
- 1978-03-13 YU YU597/78A patent/YU35248B/xx unknown
- 1978-06-12 YU YU01388/78A patent/YU138878A/xx unknown
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