ES366173A1 - Antacid composition - Google Patents
Antacid compositionInfo
- Publication number
- ES366173A1 ES366173A1 ES366173A ES366173A ES366173A1 ES 366173 A1 ES366173 A1 ES 366173A1 ES 366173 A ES366173 A ES 366173A ES 366173 A ES366173 A ES 366173A ES 366173 A1 ES366173 A1 ES 366173A1
- Authority
- ES
- Spain
- Prior art keywords
- antacid
- composition
- viscosity
- gelation agent
- gelation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title abstract 6
- 229940069428 antacid Drugs 0.000 title abstract 6
- 239000003159 antacid agent Substances 0.000 title abstract 6
- 230000001458 anti-acid effect Effects 0.000 title abstract 6
- 239000003795 chemical substances by application Substances 0.000 abstract 5
- 238000001879 gelation Methods 0.000 abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 2
- 239000007900 aqueous suspension Substances 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
- 239000010452 phosphate Substances 0.000 abstract 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910020335 Na3 PO4.12H2 O Inorganic materials 0.000 abstract 1
- JPKKQJKQTPNWTR-KQAYXBCTSA-N [(1r,5s)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2r)-3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate Chemical compound O.OS(O)(=O)=O.C1([C@H](CO)C(=O)OC2C[C@H]3CC[C@@H](C2)N3C)=CC=CC=C1.C1([C@H](CO)C(=O)OC2C[C@H]3CC[C@@H](C2)N3C)=CC=CC=C1 JPKKQJKQTPNWTR-KQAYXBCTSA-N 0.000 abstract 1
- 229940124326 anaesthetic agent Drugs 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229940124575 antispasmodic agent Drugs 0.000 abstract 1
- GUBNMFJOJGDCEL-UHFFFAOYSA-N dicyclomine hydrochloride Chemical compound [Cl-].C1CCCCC1C1(C(=O)OCC[NH+](CC)CC)CCCCC1 GUBNMFJOJGDCEL-UHFFFAOYSA-N 0.000 abstract 1
- 229940110321 dicyclomine hydrochloride Drugs 0.000 abstract 1
- 238000007865 diluting Methods 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000002772 monosaccharides Chemical class 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 229940072358 xylocaine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
An antacid composition comprises an antacid and at least one pharmaceutically acceptable gelation agent which is a waterdispersible colloidal anionic ether and/or ester of a polymer of a monosaccharide, wherein the gelation agent and the antacid are selected and the proportion thereof are such that: (1) the composition contains a major proportion of antacid and a minor proportion of gelation agent based on the combined total weight of the antacid and gelation agent in the composition, (2) the composition, when prepared in aqueous suspension so as to attain a viscosity of 300 cps. at 25 C, must be capable of containing a greater total antacid-solids concentration than that attainable without inclusion of gelation agents, and, (3) upon the progressive addition of less than 2 cc. increments of phosphate solution, having the composition defined below, per 100 grams of an aqueous suspension of fluid consistency of the formulation meeting the criteria 1 and 2, an increase in viscosity to a viscosity greater than the initial viscosity of the suspension of fluid consistency is obtained, said phosphate solution prepared by dissolving 41.6 gm. of Na 3 PO 4 .12H 2 O and 55.3 gm. NaH 2 PO 4 .H 2 O is approximately 25 ml. of hot distilled water and diluting the resulting solution to a 100 ml. volume. The composition may also contain other therapeutic substances such as anti-spasmodics, e.g. dicyclomine hydrochloride or atropine sulphate sedatives tranquillizers anti-depressants or topical anaesthetics such as xylocaine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72217668A | 1968-04-18 | 1968-04-18 | |
| US78572768A | 1968-12-20 | 1968-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES366173A1 true ES366173A1 (en) | 1971-04-01 |
Family
ID=27110553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES366173A Expired ES366173A1 (en) | 1968-04-18 | 1969-04-17 | Antacid composition |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS4621672B1 (en) |
| AU (1) | AU438147B2 (en) |
| BE (1) | BE731695A (en) |
| CA (1) | CA959760A (en) |
| CH (1) | CH536114A (en) |
| DE (1) | DE1919802A1 (en) |
| DK (1) | DK127269B (en) |
| ES (1) | ES366173A1 (en) |
| FI (1) | FI50831C (en) |
| FR (1) | FR2007475A1 (en) |
| GB (1) | GB1269987A (en) |
| IL (1) | IL32020A (en) |
| NL (1) | NL6906087A (en) |
| NO (1) | NO129077B (en) |
| SE (1) | SE388356B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1401256A (en) * | 1972-06-30 | 1975-07-16 | Miles Lab | Anticid tablet and preparation thereof |
| GB1601833A (en) * | 1978-02-06 | 1981-11-04 | Wellcome Found | Antacid formulation |
| SE7905972L (en) * | 1979-07-09 | 1981-01-10 | Haessle Ab | PROCEDURE FOR THE PREPARATION OF Gastric Acid-Neutralizing Agents, Gastric Acid-Neutralizing Agents, AND METHOD OF TREATING HYPERACIDITY AND RELATED DISEASE CONDITIONS |
| AU590578B2 (en) * | 1985-04-18 | 1989-11-09 | Procter & Gamble Company, The | Treatment of non-ulcer dyspepsia with bismuth salts |
| IT1215332B (en) * | 1987-01-12 | 1990-02-08 | Crinos Industria Farmaco | PHARMACEUTICAL COMPOSITION CONTAINING SULGLICOTIDE FOR THERAPY OF GASTRIC ULCER |
| DE3812378A1 (en) * | 1988-04-14 | 1989-10-26 | Theo Mertens | Mobile device for grinding and mixing harvested crops |
| US4988679A (en) * | 1989-01-03 | 1991-01-29 | Leonard Chavkin | Liquid sustained release composition |
| US4980175A (en) * | 1989-01-03 | 1990-12-25 | Leonard Chavkin | Liquid orally administrable compositions based on edible oils |
| DE4305919A1 (en) * | 1993-02-26 | 1994-09-01 | Ruediger Potthoff | Transporting hopper for plastics granulate |
| CA2474634C (en) * | 2002-02-04 | 2010-10-19 | Pharmacia Corporation | Stable pharmaceutical composition useful for treating gastrointestinal disorders |
| EP1488812A4 (en) * | 2002-03-04 | 2006-05-03 | Medrx Co Ltd | Liquid matrix undergoing phase transfer in vivo and liquid oral preparations |
| US20030232092A1 (en) * | 2002-06-14 | 2003-12-18 | Hasenmayer Donald L. | Liquid antacid compositions |
| US9486436B2 (en) | 2014-04-29 | 2016-11-08 | The Procter & Gamble Company | Method for making bismuth containing liquid pharmaceutical suspensions |
| RU2676261C2 (en) | 2014-04-29 | 2018-12-27 | Дзе Проктер Энд Гэмбл Компани | Bismuth-containing liquid pharmaceutical suspensions |
| CN114732828A (en) * | 2022-04-27 | 2022-07-12 | 广西南宁百会药业集团有限公司 | Hydrotalcite suspension and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE621147A (en) * |
-
1969
- 1969-04-14 GB GB09070/69A patent/GB1269987A/en not_active Expired
- 1969-04-14 IL IL32020A patent/IL32020A/en unknown
- 1969-04-15 NO NO1526/69A patent/NO129077B/no unknown
- 1969-04-15 FI FI691089A patent/FI50831C/en active
- 1969-04-16 CA CA048,813A patent/CA959760A/en not_active Expired
- 1969-04-16 AU AU53539/69A patent/AU438147B2/en not_active Expired
- 1969-04-17 ES ES366173A patent/ES366173A1/en not_active Expired
- 1969-04-17 DK DK209369AA patent/DK127269B/en unknown
- 1969-04-18 NL NL6906087A patent/NL6906087A/xx unknown
- 1969-04-18 JP JP3015469A patent/JPS4621672B1/ja active Pending
- 1969-04-18 SE SE6905549A patent/SE388356B/en unknown
- 1969-04-18 DE DE19691919802 patent/DE1919802A1/en not_active Ceased
- 1969-04-18 CH CH593269A patent/CH536114A/en not_active IP Right Cessation
- 1969-04-18 BE BE731695D patent/BE731695A/xx unknown
- 1969-04-18 FR FR6912182A patent/FR2007475A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4621672B1 (en) | 1971-06-19 |
| CH536114A (en) | 1973-04-30 |
| NO129077B (en) | 1974-02-25 |
| CA959760A (en) | 1974-12-24 |
| DK127269B (en) | 1973-10-15 |
| FR2007475A1 (en) | 1970-01-09 |
| FI50831C (en) | 1976-08-10 |
| BE731695A (en) | 1969-10-20 |
| AU438147B2 (en) | 1973-07-18 |
| IL32020A (en) | 1972-11-28 |
| DE1919802A1 (en) | 1969-11-06 |
| SE388356B (en) | 1976-10-04 |
| NL6906087A (en) | 1969-10-21 |
| FI50831B (en) | 1976-04-30 |
| AU5353969A (en) | 1970-10-22 |
| GB1269987A (en) | 1972-04-12 |
| IL32020A0 (en) | 1969-06-25 |
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