ES315051A1 - Method for the preparation of derivatives of natural isoflavones. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Method for the preparation of natural isoflavone derivatives of the general formula (I): ** (See formula) ** wherein R represents a hydrogen atom or a hydroxyl, represents a hydrogen atom or a methyl group, R 2 represents a dialkylaminoalkyl radical, in particular dimethylaminoethyl or diethylaminoethyl, or an alkyl group substituted or not, in particular the bromoethyl group , or the carboethoxymethyl group, and R3 represents a hydrogen atom or a methyl group, characterized in that the alkali salts with the hydroxyl in position 7 of isoflavone compounds of general formula (II) are reacted in anhydrous solvents at room temperature between room temperature and boiling point of the solvent: ** (See formula) ** wherein R, R1 and R3 have the same meanings as above, with compounds of the general formula R2X, in which R2 represents a dialkylaminoalkyl radical, in particular dimethylaminoethyl or diethylaminoethyl, or an alkyl radical substituted or not, in particular the radical bromoethyl or a carboethoxymethyl radical, while X represents a halogen atom, in particular chlorine or bromine, and, in the case where R 2 represents a halogenetyl radical, the compounds thus obtained are optionally reacted with a secondary amine, in the presence of solvents or in an excess of the same amine. (Machine-translation by Google Translate, not legally binding)