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ES286808A1 - A PROCEDURE FOR THE PREPARATION OF BENZOXAZEPIN DERIVATIVES - Google Patents

A PROCEDURE FOR THE PREPARATION OF BENZOXAZEPIN DERIVATIVES

Info

Publication number
ES286808A1
ES286808A1 ES286808A ES286808A ES286808A1 ES 286808 A1 ES286808 A1 ES 286808A1 ES 286808 A ES286808 A ES 286808A ES 286808 A ES286808 A ES 286808A ES 286808 A1 ES286808 A1 ES 286808A1
Authority
ES
Spain
Prior art keywords
preparation
halogen
derivatives
formula
benzoxazepin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES286808A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES286808A1 publication Critical patent/ES286808A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A process for the preparation of benzoxazepine derivatives, characterized in comprising the cyclization of a compound of the formula ** (See formula) ** where R1 represents hydrogen or lower alkyl, R2 represents hydrogen or halogen, R3 represents hydrogen, halogen or sulfamyl and X represents halogen, by intramolecular elimination of hydrogen halide, converting it into a compound of the formula ** (See formula) ** where R1, R2 and R3 have the same meaning as before, and, if the conversion of the latter compound into a salt is desired. (Machine-translation by Google Translate, not legally binding)
ES286808A 1962-04-06 1963-04-05 A PROCEDURE FOR THE PREPARATION OF BENZOXAZEPIN DERIVATIVES Expired ES286808A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18551262A 1962-04-06 1962-04-06

Publications (1)

Publication Number Publication Date
ES286808A1 true ES286808A1 (en) 1963-11-16

Family

ID=22681287

Family Applications (2)

Application Number Title Priority Date Filing Date
ES286808A Expired ES286808A1 (en) 1962-04-06 1963-04-05 A PROCEDURE FOR THE PREPARATION OF BENZOXAZEPIN DERIVATIVES
ES0286809A Expired ES286809A1 (en) 1962-04-06 1963-04-05 Novel benzoxazepine derivatives and a process for the manufacture thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES0286809A Expired ES286809A1 (en) 1962-04-06 1963-04-05 Novel benzoxazepine derivatives and a process for the manufacture thereof

Country Status (5)

Country Link
BE (1) BE630572A (en)
BR (1) BR6348190D0 (en)
CH (1) CH428741A (en)
ES (2) ES286808A1 (en)
GB (2) GB980592A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906635A (en) * 1983-11-25 1990-03-06 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents
US5017567A (en) * 1983-11-25 1991-05-21 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents
US4778795A (en) * 1983-11-25 1988-10-18 Schering Corporation Carboxyalkyl dipeptides as antiglaucoma agents

Also Published As

Publication number Publication date
ES286809A1 (en) 1963-10-16
BR6348190D0 (en) 1973-07-03
GB980593A (en) 1965-01-13
CH428741A (en) 1967-01-31
BE630572A (en) 1963-11-04
GB980592A (en) 1965-01-13

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