ES252321A1 - Procedimiento para la obtenciën de nuevos compuestos esteroides - Google Patents
Procedimiento para la obtenciën de nuevos compuestos esteroidesInfo
- Publication number
- ES252321A1 ES252321A1 ES0252321A ES252321A ES252321A1 ES 252321 A1 ES252321 A1 ES 252321A1 ES 0252321 A ES0252321 A ES 0252321A ES 252321 A ES252321 A ES 252321A ES 252321 A1 ES252321 A1 ES 252321A1
- Authority
- ES
- Spain
- Prior art keywords
- dialkyl
- bismethylenedioxy
- alkyl
- pregnene
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- 238000000034 method Methods 0.000 abstract 6
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- -1 alkyl radical Chemical class 0.000 abstract 3
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 abstract 2
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 abstract 2
- SUPOKHOQAKXOHJ-BYZMTCBYSA-N (8s,9s,10r,13r,14s,17s)-17-ethyl-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene Chemical compound C1CC2=CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC)[C@@]1(C)CC2 SUPOKHOQAKXOHJ-BYZMTCBYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000004791 alkyl magnesium halides Chemical class 0.000 abstract 1
- SMZOGRDCAXLAAR-UHFFFAOYSA-N aluminium isopropoxide Chemical compound [Al+3].CC(C)[O-].CC(C)[O-].CC(C)[O-] SMZOGRDCAXLAAR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 229940117975 chromium trioxide Drugs 0.000 abstract 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N chromium trioxide Inorganic materials O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 abstract 1
- GAMDZJFZMJECOS-UHFFFAOYSA-N chromium(6+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Cr+6] GAMDZJFZMJECOS-UHFFFAOYSA-N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 235000011056 potassium acetate Nutrition 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para la obtención de nuevos compuestos esteroides, que comprende la reacción de 21-acilato de 16 alfa-alquil-5,¿-dihalo-3 beta,17 alfa, 21-trihidroxi 20-pregnanona con un reductor, para formar 21- acilato de 16 alfa-alquil-3 beta,17 alfa, 21-trihidroxi-5-pregnen-20-ona.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US760562A US3094523A (en) | 1958-09-12 | 1958-09-12 | 6alpha, 16alpha-dialkyl steroid intermediates and proceses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES252321A1 true ES252321A1 (es) | 1960-02-01 |
Family
ID=25059481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0252321A Expired ES252321A1 (es) | 1958-09-12 | 1959-09-12 | Procedimiento para la obtenciën de nuevos compuestos esteroides |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3094523A (es) |
| BE (1) | BE582617A (es) |
| CH (1) | CH392502A (es) |
| CU (1) | CU31485A (es) |
| ES (1) | ES252321A1 (es) |
| GB (2) | GB934802A (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3201429A (en) * | 1958-07-12 | 1965-08-17 | Syntex Corp | 17, 21-diesters of 6alpha, 16alpha-dimethyl-delta4-pregnen-17alpha-21-diol-3, 20-dione and process therefor |
| US3186985A (en) * | 1963-05-07 | 1965-06-01 | Schering Corp | Novel 6-keto-4-dehydro-steroids and processes for their manufacture |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2602769A (en) * | 1952-02-23 | 1952-07-08 | Upjohn Co | Oxygenation of steroids by mucorales fungi |
| US2805230A (en) * | 1952-08-02 | 1957-09-03 | Syntex Sa | Esters of 17alpha-hydroxy progesterone |
| US2658023A (en) * | 1953-04-21 | 1953-11-03 | Pfizer & Co C | Oxygenation of steroids |
| US2786053A (en) * | 1953-04-23 | 1957-03-19 | Merck & Co Inc | Process of converting delta9(11)-7-keto-steroids to the corresponding 11-keto-steroids |
| US2859223A (en) * | 1955-01-25 | 1958-11-04 | Merck & Co Inc | delta4, 7-3, 20-diketo-17-hydroxy-11, 21-bis-oxygenated pregnadienes and processes of preparing the same |
| US2813882A (en) * | 1955-01-25 | 1957-11-19 | Merck & Co Inc | delta-3, 20-diketo-17-hydroxy-11, 21-bis oxygenated-pregnadiene compounds and processes of preparing the same |
| US2866799A (en) * | 1957-01-02 | 1958-12-30 | Merck & Co Inc | Method for converting a 17-20, 20-21 bismethylenedioxy or a 17-20, 20-21 bis-substituted methylenedioxy steroid of the pregnane series to a 17alpha, 21-dihydroxy-20-ketosteroid of the pregnane series |
| US2888457A (en) * | 1958-08-18 | 1959-05-26 | Merck & Co Inc | Bismethylenedioxy steroids and methods of making same |
-
1958
- 1958-09-12 US US760562A patent/US3094523A/en not_active Expired - Lifetime
-
1959
- 1959-08-25 CU CU5931485A patent/CU31485A/es unknown
- 1959-09-08 GB GB12543/63A patent/GB934802A/en not_active Expired
- 1959-09-08 GB GB30629/59A patent/GB934801A/en not_active Expired
- 1959-09-11 CH CH7812559A patent/CH392502A/de unknown
- 1959-09-12 BE BE582617A patent/BE582617A/fr unknown
- 1959-09-12 ES ES0252321A patent/ES252321A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB934801A (en) | 1963-08-21 |
| US3094523A (en) | 1963-06-18 |
| CU31485A (en) | 1981-12-04 |
| BE582617A (fr) | 1960-03-14 |
| GB934802A (en) | 1963-08-21 |
| CH392502A (de) | 1965-05-31 |
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