ES2160495B1 - USE OF VIP AND PACAP PEPTIDES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES IN MAMMALS. - Google Patents
USE OF VIP AND PACAP PEPTIDES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES IN MAMMALS.Info
- Publication number
- ES2160495B1 ES2160495B1 ES9901235A ES9901235A ES2160495B1 ES 2160495 B1 ES2160495 B1 ES 2160495B1 ES 9901235 A ES9901235 A ES 9901235A ES 9901235 A ES9901235 A ES 9901235A ES 2160495 B1 ES2160495 B1 ES 2160495B1
- Authority
- ES
- Spain
- Prior art keywords
- mammals
- inflammatory
- treatment
- autoimmune diseases
- vip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 3
- 241000124008 Mammalia Species 0.000 title abstract 3
- 208000027866 inflammatory disease Diseases 0.000 title abstract 3
- 230000002757 inflammatory effect Effects 0.000 title abstract 3
- 102000002808 Pituitary adenylate cyclase-activating polypeptide Human genes 0.000 title 1
- 108010004684 Pituitary adenylate cyclase-activating polypeptide Proteins 0.000 title 1
- 206010014824 Endotoxic shock Diseases 0.000 abstract 2
- 206010040070 Septic Shock Diseases 0.000 abstract 2
- 102000004388 Interleukin-4 Human genes 0.000 abstract 1
- 108090000978 Interleukin-4 Proteins 0.000 abstract 1
- 102000004889 Interleukin-6 Human genes 0.000 abstract 1
- 108090001005 Interleukin-6 Proteins 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102000055135 Vasoactive Intestinal Peptide Human genes 0.000 abstract 1
- 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 108060000200 adenylate cyclase Proteins 0.000 abstract 1
- 102000030621 adenylate cyclase Human genes 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229940028885 interleukin-4 Drugs 0.000 abstract 1
- 229940100601 interleukin-6 Drugs 0.000 abstract 1
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Composición y método para el tratamiento del shock endotóxico y enfermedades inflamatorias y autoinmunes en mamíferos. Se describe la composición y uso de agentes terapéuticos que inhiben la producción de factor de necrosis tumoral e interleuquina 6, y que inducen elevados niveles de interleuquina 4 para el tratamiento del shock endotóxico y enfermedades inflamatorias y autoinmunes, respectivamente, en mamíferos. La composición incluye substancias tales como péptido intestinal vasoactivo, péptido activador de la adenilato ciclasa hipofisaria, sus respectivos fragmentos y derivados.Composition and method for the treatment of endotoxic shock and inflammatory and autoimmune diseases in mammals. The composition and use of therapeutic agents that inhibit the production of tumor necrosis factor and interleukin 6, and that induce high levels of interleukin 4 for the treatment of endotoxic shock and inflammatory and autoimmune diseases, respectively, in mammals, are described. The composition includes substances such as vasoactive intestinal peptide, pituitary adenylate cyclase activating peptide, their respective fragments and derivatives.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9901235A ES2160495B1 (en) | 1998-04-17 | 1999-06-04 | USE OF VIP AND PACAP PEPTIDES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES IN MAMMALS. |
| PT00931296T PT1103270E (en) | 1999-06-04 | 2000-06-02 | TREATMENT OF AUTO-IMMUNE DISEASES IN MAMMALS |
| DE60002143T DE60002143T2 (en) | 1999-06-04 | 2000-06-02 | TREATMENT OF AUTOIMMUNE DISEASES IN MAMMALS |
| CA002345030A CA2345030A1 (en) | 1999-06-04 | 2000-06-02 | Composition and method for the treatment of endotoxic shock and inflammatory and autoimmune diseases in mammals |
| AT00931296T ATE237347T1 (en) | 1999-06-04 | 2000-06-02 | TREATMENT OF AUTOIMMUNE DISEASES IN MAMMALS |
| AU49277/00A AU4927700A (en) | 1999-06-04 | 2000-06-02 | Method for treating endotoxic shock and inflammatory and autoimmune diseases in mammals |
| PCT/ES2000/000197 WO2000074708A1 (en) | 1999-06-04 | 2000-06-02 | Method for treating endotoxic shock and inflammatory and autoimmune diseases in mammals |
| EP00931296A EP1103270B1 (en) | 1999-06-04 | 2000-06-02 | Treatment of autoimmune diseases in mammals |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009800814A ES2138561B1 (en) | 1998-04-17 | 1998-04-17 | USE OF VIP PEPTIDES AND PACAP IN THE TREATMENT OF ENDOTOXIC SHOCK IN MAMMALS. |
| ES9901235A ES2160495B1 (en) | 1998-04-17 | 1999-06-04 | USE OF VIP AND PACAP PEPTIDES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES IN MAMMALS. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2160495A1 ES2160495A1 (en) | 2001-11-01 |
| ES2160495B1 true ES2160495B1 (en) | 2002-09-16 |
Family
ID=26155143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9901235A Expired - Fee Related ES2160495B1 (en) | 1998-04-17 | 1999-06-04 | USE OF VIP AND PACAP PEPTIDES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES IN MAMMALS. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2160495B1 (en) |
-
1999
- 1999-06-04 ES ES9901235A patent/ES2160495B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2160495A1 (en) | 2001-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20011101 Kind code of ref document: A1 Effective date: 20011101 |
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| FD2A | Announcement of lapse in spain |
Effective date: 20190926 |