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ES2039299A1 - Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales. - Google Patents

Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.

Info

Publication number
ES2039299A1
ES2039299A1 ES9102196A ES9102196A ES2039299A1 ES 2039299 A1 ES2039299 A1 ES 2039299A1 ES 9102196 A ES9102196 A ES 9102196A ES 9102196 A ES9102196 A ES 9102196A ES 2039299 A1 ES2039299 A1 ES 2039299A1
Authority
ES
Spain
Prior art keywords
group
substituted
obtaining
halogen atoms
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9102196A
Other languages
English (en)
Other versions
ES2039299B1 (es
Inventor
Pinilla Paloma Esteban
Jose Fernandez-Simon
Pablo Bernard
Martin Juan Antonio Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AsturPharma SA
Original Assignee
AsturPharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AsturPharma SA filed Critical AsturPharma SA
Priority to ES9102196A priority Critical patent/ES2039299B1/es
Publication of ES2039299A1 publication Critical patent/ES2039299A1/es
Application granted granted Critical
Publication of ES2039299B1 publication Critical patent/ES2039299B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESTERES DEL ACIDO 1, 1-DROXOPENICILANICO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES DE FORMULA I (ESQUEMA I), DONDE R REPRESENTA UN ANILLO AROMATICO O HETEROAROMATICO, SUSTITUIDO O NO POR GRUPOS ALQUILO INFERIOR, HIDROXILO, ALCOXILO INFERIOR, CARBOXILO Y/O ARILO, SUSTITUIDO O NO, A SU VEZ, POR ATOMOS DE HALOGENO, O UN RESTO DEL TIPO R1R2CH-, DONDE R1 REPRESENTA UN ATOMO DE HIDROGENO, UN RESTO ALQUILO INFERIOR O UN GRUPO ARILO O HETEROARILO SUSTITUIDO O NO POR RESTOS HIDROXILO O ATOMOS DE HALOGENO, Y R2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALCOXILO INFERIOR, ARILOXI, AMINO, CARBOXILO O UN GRUPO DEL TIPO -COOR3 DONDE R3 REPRESENTA UN GRUPO FENILO O CICLOPENTAFENILO. SE OBTIENE HACIENDO REACCIONAR EL COMPUESTO II, DONDE X REPRESENTA UN ATOMO BROMO CON METAL REDUCTOR EN POLVO EN MEDIO ACUOSO/ORGANICO. SON UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS.
ES9102196A 1991-10-04 1991-10-04 Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales. Expired - Fee Related ES2039299B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9102196A ES2039299B1 (es) 1991-10-04 1991-10-04 Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9102196A ES2039299B1 (es) 1991-10-04 1991-10-04 Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.

Publications (2)

Publication Number Publication Date
ES2039299A1 true ES2039299A1 (es) 1993-09-16
ES2039299B1 ES2039299B1 (es) 1994-05-16

Family

ID=8273730

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9102196A Expired - Fee Related ES2039299B1 (es) 1991-10-04 1991-10-04 Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.

Country Status (1)

Country Link
ES (1) ES2039299B1 (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2100125A1 (es) * 1995-06-02 1997-06-01 Asturpharma S A Procedimiento de preparacion de esteres de matanodiol de acido dioxopeneicilanico.
WO2000034289A1 (en) * 1998-12-08 2000-06-15 Eli Lilly And Company Process of preparing esters of penicillanic acid sulfoxide
EP1041075A1 (en) * 1999-03-03 2000-10-04 Alex-Gyogyszer Kutatási Procedure for the preparation of dioxopenicillanic acid derivatives
WO2007004239A1 (en) * 2005-07-06 2007-01-11 Morepen Laboratories Limited New polymorphic form of sultamicillin tosylate and a process therefor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8305767A1 (es) * 1981-03-23 1983-04-16 Pfizer Un procedimiento para la preparacion de derivados de 1,1-dioxido del acido penicilanico.
ES8403132A1 (es) * 1981-03-23 1984-03-01 Pfizer Un procedimiento para la preparacion de bis-esteres de metanodiol.
ES8405019A1 (es) * 1982-04-19 1984-05-16 Gist Brocades Nv Procedimiento de preparacion de 1,1-dioxidos de acido penicilanico y derivados del mismo.
ES8504824A1 (es) * 1982-12-06 1985-05-01 Pfizer Un procedimiento para la preparacion de un compuesto de sultamicilina

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8305767A1 (es) * 1981-03-23 1983-04-16 Pfizer Un procedimiento para la preparacion de derivados de 1,1-dioxido del acido penicilanico.
ES8403132A1 (es) * 1981-03-23 1984-03-01 Pfizer Un procedimiento para la preparacion de bis-esteres de metanodiol.
ES8405019A1 (es) * 1982-04-19 1984-05-16 Gist Brocades Nv Procedimiento de preparacion de 1,1-dioxidos de acido penicilanico y derivados del mismo.
ES8504824A1 (es) * 1982-12-06 1985-05-01 Pfizer Un procedimiento para la preparacion de un compuesto de sultamicilina

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2100125A1 (es) * 1995-06-02 1997-06-01 Asturpharma S A Procedimiento de preparacion de esteres de matanodiol de acido dioxopeneicilanico.
WO2000034289A1 (en) * 1998-12-08 2000-06-15 Eli Lilly And Company Process of preparing esters of penicillanic acid sulfoxide
EP1041075A1 (en) * 1999-03-03 2000-10-04 Alex-Gyogyszer Kutatási Procedure for the preparation of dioxopenicillanic acid derivatives
WO2007004239A1 (en) * 2005-07-06 2007-01-11 Morepen Laboratories Limited New polymorphic form of sultamicillin tosylate and a process therefor

Also Published As

Publication number Publication date
ES2039299B1 (es) 1994-05-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041005