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ES2038172T3 - Procedimiento para preparar carboxamidas heterociclicas. - Google Patents

Procedimiento para preparar carboxamidas heterociclicas.

Info

Publication number
ES2038172T3
ES2038172T3 ES198787303221T ES87303221T ES2038172T3 ES 2038172 T3 ES2038172 T3 ES 2038172T3 ES 198787303221 T ES198787303221 T ES 198787303221T ES 87303221 T ES87303221 T ES 87303221T ES 2038172 T3 ES2038172 T3 ES 2038172T3
Authority
ES
Spain
Prior art keywords
formula
procedure
cyclic carboxamides
hetero cyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787303221T
Other languages
English (en)
Inventor
Frederick Jeffrey Brown
Ying Kwong Yee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeneca Inc
Original Assignee
ICI Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868609175A external-priority patent/GB8609175D0/en
Priority claimed from GB868624698A external-priority patent/GB8624698D0/en
Application filed by ICI Americas Inc filed Critical ICI Americas Inc
Application granted granted Critical
Publication of ES2038172T3 publication Critical patent/ES2038172T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTA INVENCION PRESENTA UNA SERIE DE NUEVAS CARBOXAMIDAS HETEROCICLICAS DE FORMULA I EN LA CUAL EL GRUPO -Y-Z< ES SELECCIONADO DE -C(RA)=C<, -N=C<, Y -CH(RA)-CH< Y LOS OTROS RADICALES SE DEFINEN EN LA SIGUIENTE ESPECIFICACION. LOS COMPUESTOS DE FORMULA I SON ANTAGONISTAS DE LEUCOTRIENO. LA INVENCION TAMBIEN PRESENTA SALES FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS DE LA FORMULA I; COMPOSICIONES FARMACEUTICAS QUE CONTIENEN EL COMPUESTO DE FORMULA I, O SUS SALES, PARA USAR EN EL TRATAMIENTO DE, POR EJEMPLO, ENFERMEDADES ALERGICAS O INFLAMATORIAS, O CONDICIONES DE SHOCK TRAUMATICO O ENDOTOXICO, Y PROCESOS PARA LA FABRICACION DE LOS COMPUESTOS DE LA FORMULA I, ASI COMO PRODUCTOS INTERMEDIOS PARA USAR EN DICHA FABRICACION.
ES198787303221T 1986-04-15 1987-04-13 Procedimiento para preparar carboxamidas heterociclicas. Expired - Lifetime ES2038172T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868609175A GB8609175D0 (en) 1986-04-15 1986-04-15 Heterocyclic carboxamides
GB868624698A GB8624698D0 (en) 1986-10-15 1986-10-15 Heterocyclic carboxamides

Publications (1)

Publication Number Publication Date
ES2038172T3 true ES2038172T3 (es) 1993-07-16

Family

ID=26290629

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787303221T Expired - Lifetime ES2038172T3 (es) 1986-04-15 1987-04-13 Procedimiento para preparar carboxamidas heterociclicas.

Country Status (20)

Country Link
EP (1) EP0242167B1 (es)
JP (1) JPH0768211B2 (es)
KR (1) KR870010010A (es)
CN (1) CN87103504A (es)
AU (1) AU602515B2 (es)
DE (1) DE3774749D1 (es)
DK (1) DK190587A (es)
ES (1) ES2038172T3 (es)
FI (1) FI871632A7 (es)
GB (1) GB8707051D0 (es)
GR (1) GR3003209T3 (es)
HU (1) HU199791B (es)
IE (1) IE60013B1 (es)
IL (1) IL82126A0 (es)
NO (1) NO871588L (es)
NZ (1) NZ219978A (es)
PL (1) PL153341B1 (es)
PT (1) PT84681B (es)
SU (1) SU1597098A3 (es)
ZW (1) ZW6387A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3650567T2 (de) * 1985-10-17 1997-02-20 Zeneca Inc Medizinische Indol- und Indazol-Ketosulfonderivate
MY103259A (en) * 1987-04-15 1993-05-29 Ici America Inc Aliphatic carboxamides
US5281593A (en) * 1990-07-31 1994-01-25 Lilly Industries Limited Certain indole derivatives useful as leukotriene antagonists
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
GB9020338D0 (en) * 1990-09-18 1990-10-31 Lilly Industries Ltd Pharmaceutical compounds
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
NZ314601A (en) * 1996-04-19 1999-09-29 American Home Prod 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole derivatives as estrogenic agents and pharmaceutical compositions
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
BR9712782A (pt) * 1996-06-25 1999-12-07 Pfizer Derivados de indazol substituìdo e seu uso como inibidores de fosfodiesterose (pde) e fator de necrose de tumor (tnf)
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
US6069153A (en) * 1998-05-12 2000-05-30 American Home Products Corporation Indenoindoles and benzocarbazoles as estrogenic agents
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
US6159959A (en) * 1999-05-06 2000-12-12 American Home Products Corporation Combined estrogen and antiestrogen therapy
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
BRPI0507861A (pt) 2004-02-20 2007-07-17 Boehringer Ingelheim Int inibidores de polimerase viral
EP1915378A4 (en) 2005-08-12 2009-07-22 Boehringer Ingelheim Int VIRUS POLYMERASE INHIBITORS
EP1943245A2 (en) * 2005-09-07 2008-07-16 Plexxikon, Inc. 1,3-disubstituted indole derivatives for use as ppar modulators
CN101130515B (zh) * 2006-08-24 2011-06-15 中国科学院上海药物研究所 取代-1h-吲哚类化合物、其制备方法、其应用及其药物组合物
GEP20135878B (en) * 2009-08-03 2013-07-10 Aziende Chimiche Riunite Angelini Francesco A C R A F S P A It Method of 1-benzyl-3-hydroxymethyl-1h-indazole preparation, derivatives thereof, and required magnesium intermediates
CN105837477B (zh) * 2016-06-14 2017-07-21 岳阳蓬诚科技发展有限公司 一种二甲基砜的制备方法
CN105884662B (zh) * 2016-06-14 2017-07-21 岳阳蓬诚科技发展有限公司 一种二甲基砜的生产工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE738727C (de) * 1942-07-11 1943-08-30 August Engels G M B H Vorrichtung zum Entleeren von Formkaesten
US3271416A (en) * 1961-10-24 1966-09-06 Merck & Co Inc Indolyl aliphatic acids
FR4035M (es) * 1964-11-04 1966-03-28
FR7631M (es) * 1968-08-13 1970-01-26
US3470298A (en) * 1969-01-29 1969-09-30 Acraf Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
US4436746A (en) * 1982-09-30 1984-03-13 Ciba-Geigy Corporation Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
CA1241660A (en) * 1984-06-25 1988-09-06 Yvan Guindon Indole-2-alkanoic acids
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides

Also Published As

Publication number Publication date
JPH0768211B2 (ja) 1995-07-26
GB8707051D0 (en) 1987-04-29
DK190587D0 (da) 1987-04-13
FI871632A0 (fi) 1987-04-14
NO871588D0 (no) 1987-04-14
EP0242167A2 (en) 1987-10-21
HUT43819A (en) 1987-12-28
NZ219978A (en) 1990-08-28
DK190587A (da) 1987-10-16
IE60013B1 (en) 1994-05-18
EP0242167A3 (en) 1988-10-12
AU7139387A (en) 1987-10-22
HU199791B (en) 1990-03-28
PL265151A1 (en) 1989-03-06
PL153341B1 (en) 1991-04-30
ZW6387A1 (en) 1988-11-23
GR3003209T3 (en) 1993-02-17
IL82126A0 (en) 1987-10-30
AU602515B2 (en) 1990-10-18
IE870837L (en) 1987-10-15
NO871588L (no) 1987-10-16
DE3774749D1 (de) 1992-01-09
FI871632A7 (fi) 1987-10-16
JPS638369A (ja) 1988-01-14
PT84681A (en) 1987-05-01
CN87103504A (zh) 1987-12-09
PT84681B (pt) 1989-12-29
KR870010010A (ko) 1987-11-30
SU1597098A3 (ru) 1990-09-30
EP0242167B1 (en) 1991-11-27

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