ES2035767A1 - Procedimiento de obtencion de 2-hidroximetil-3,5-dimetilpiridinas 4-sustituidas. - Google Patents
Procedimiento de obtencion de 2-hidroximetil-3,5-dimetilpiridinas 4-sustituidas.Info
- Publication number
- ES2035767A1 ES2035767A1 ES9100890A ES9100890A ES2035767A1 ES 2035767 A1 ES2035767 A1 ES 2035767A1 ES 9100890 A ES9100890 A ES 9100890A ES 9100890 A ES9100890 A ES 9100890A ES 2035767 A1 ES2035767 A1 ES 2035767A1
- Authority
- ES
- Spain
- Prior art keywords
- dimethyl
- pyridine
- hydroxymethyl
- obtaining
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 4-substituted 2-hydroxymethyl-3,5- dimethyl pyridines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract 1
- SIOXPEMLGUPBBT-UHFFFAOYSA-N Picolinic acid Natural products OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006392 deoxygenation reaction Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229960000381 omeprazole Drugs 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-M oxidooxomethyl Chemical compound [O-][C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-M 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE 2-HIDROXIMETIL-3,5-DIMETIL-4-R-PIRIDINA, DE FORMULA I FORMULA DONDE R ES UN GRUPO NITRO O METOXILO, QUE COMPRENDE: A) DESOXIGENACION E INTRODUCCION DE UN GRUPO CIANO EN POSICION 2 DEL N-OXIDO DE 3,5-DIMETIL-4-R-PIRIDINA, DE FORMULA III, OBTENIENDO EL 3,5-DIMETIL-4-R-PIRIDIN-2-CARBONITRILO; B) HIDROLISIS DEL GRUPO CIANO DE ESTE ULTIMO COMPUESTO, RINDIENDO EL ACIDO 3,5-DIMETIL-4-R-PIRIDIN-2-CARBOXILICO, Y C) REDUCCION DEL RADICAL CARBOXILO DEL ANTERIOR ACIDO, RINDIENDO EL COMPUESTO DE FORMULA I. EL COMPUESTO DE FORMULA I ES UN INTERMEDIO DE LA SINTESIS DEL OMEPRAZOL, EL CUAL ES UN MEDICAMENTO MUY EFICAZ.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9100890A ES2035767B1 (es) | 1991-04-05 | 1991-04-05 | Procedimiento de obtencion de 2-hidroximetil-3,5-dimetilpiridinas 4-sustituidas. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9100890A ES2035767B1 (es) | 1991-04-05 | 1991-04-05 | Procedimiento de obtencion de 2-hidroximetil-3,5-dimetilpiridinas 4-sustituidas. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2035767A1 true ES2035767A1 (es) | 1993-04-16 |
| ES2035767B1 ES2035767B1 (es) | 1994-02-01 |
Family
ID=8271987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9100890A Expired - Fee Related ES2035767B1 (es) | 1991-04-05 | 1991-04-05 | Procedimiento de obtencion de 2-hidroximetil-3,5-dimetilpiridinas 4-sustituidas. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2035767B1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2097089A1 (es) * | 1995-02-01 | 1997-03-16 | Esteve Quimica Sa | Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina. |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9717849D0 (en) * | 1997-08-23 | 1997-10-29 | Seal Sands Chemicals Limited | Preparation of pyridene derivatives |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0369208A1 (de) * | 1988-11-15 | 1990-05-23 | Hafslund Nycomed Pharma Aktiengesellschaft | Verfahren zur Herstellung von 3,5-Dimethyl-4-methoxypyridinderivaten sowie neues Zwischenprodukt hierfür |
-
1991
- 1991-04-05 ES ES9100890A patent/ES2035767B1/es not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0369208A1 (de) * | 1988-11-15 | 1990-05-23 | Hafslund Nycomed Pharma Aktiengesellschaft | Verfahren zur Herstellung von 3,5-Dimethyl-4-methoxypyridinderivaten sowie neues Zwischenprodukt hierfür |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2097089A1 (es) * | 1995-02-01 | 1997-03-16 | Esteve Quimica Sa | Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina. |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2035767B1 (es) | 1994-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000201 |