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ES2021944A6 - New derivatives of 1,3,5-triamino-2,4,6-triiodobenzene and method for the preparation thereof - Google Patents

New derivatives of 1,3,5-triamino-2,4,6-triiodobenzene and method for the preparation thereof

Info

Publication number
ES2021944A6
ES2021944A6 ES9000432A ES9000432A ES2021944A6 ES 2021944 A6 ES2021944 A6 ES 2021944A6 ES 9000432 A ES9000432 A ES 9000432A ES 9000432 A ES9000432 A ES 9000432A ES 2021944 A6 ES2021944 A6 ES 2021944A6
Authority
ES
Spain
Prior art keywords
preparation
triiodobenzene
triamino
derivatives
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9000432A
Other languages
Spanish (es)
Inventor
Mateo Ana Calvo
Morales Manuel Esteban
Camara M Teresa Gallego
Munoz Manuel Munoz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Farma SA
Original Assignee
Rhone Poulenc Farma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Farma SA filed Critical Rhone Poulenc Farma SA
Priority to ES9000432A priority Critical patent/ES2021944A6/en
Priority to AU71899/91A priority patent/AU7189991A/en
Priority to PCT/ES1991/000008 priority patent/WO1991012231A1/en
Priority to JP3503749A priority patent/JPH04505461A/en
Publication of ES2021944A6 publication Critical patent/ES2021944A6/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

New derivatives of 1,3,5-triamino-2,4,6-triiodobenzene and method for the preparation of such derivatives. Said derivatives have the formula (V and VI) wherein the various radicals have the signification indicated in the description. The preparation method for (V) consists in reacting compounds of formula (VII) wherein R<4> has the significations given in the description with compounds of formula Z-R<10> wherein Z and R<10> have also the significations given in the description. The compounds (V and VI) find application as non ionic contrast agents for radiological clinical diagnosis.
ES9000432A 1990-02-14 1990-02-14 New derivatives of 1,3,5-triamino-2,4,6-triiodobenzene and method for the preparation thereof Expired - Lifetime ES2021944A6 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES9000432A ES2021944A6 (en) 1990-02-14 1990-02-14 New derivatives of 1,3,5-triamino-2,4,6-triiodobenzene and method for the preparation thereof
AU71899/91A AU7189991A (en) 1990-02-14 1991-02-04 New derivatives of 1,3,5-triamino-2,4,6-triiodobenzene and method for the preparation thereof
PCT/ES1991/000008 WO1991012231A1 (en) 1990-02-14 1991-02-04 New derivatives of 1,3,5-triamino-2,4,6-triiodobenzene and method for the preparation thereof
JP3503749A JPH04505461A (en) 1990-02-14 1991-02-04 A novel derivative of 1,3,5-triamino-2,4,6-triiodobenzene and its production method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9000432A ES2021944A6 (en) 1990-02-14 1990-02-14 New derivatives of 1,3,5-triamino-2,4,6-triiodobenzene and method for the preparation thereof

Publications (1)

Publication Number Publication Date
ES2021944A6 true ES2021944A6 (en) 1991-11-16

Family

ID=8265921

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9000432A Expired - Lifetime ES2021944A6 (en) 1990-02-14 1990-02-14 New derivatives of 1,3,5-triamino-2,4,6-triiodobenzene and method for the preparation thereof

Country Status (4)

Country Link
JP (1) JPH04505461A (en)
AU (1) AU7189991A (en)
ES (1) ES2021944A6 (en)
WO (1) WO1991012231A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9303992D0 (en) * 1993-02-26 1993-04-14 Nycomed Imaging As Contrast agents
WO1994022810A1 (en) * 1993-04-01 1994-10-13 Centro Investigacion Justesa Imagen, S.A. New non-ionic iodine-containing dimers useful as x-rays contrast agents, method for the preparation thereof, and galenical compositions containing them
CA2514034C (en) 2003-02-14 2013-04-16 Ciba Specialty Chemicals Holding Inc. Resin compositions containing amides as nucleating agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2313917A1 (en) * 1975-06-10 1977-01-07 Cortial Beta-amino propionic acid contrast agents - with (N)-acetyl-(N)-(3,5)-diamino-(2,4,6)-triiodo-phenyl substituents for intravenous cholecystography
FR2571367B1 (en) * 1984-10-09 1987-02-13 Guerbet Sa IODATED AND / OR BROMINATED TRIAMINOBENZENIC COMPOUNDS, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN CONTRAST PRODUCTS

Also Published As

Publication number Publication date
WO1991012231A1 (en) 1991-08-22
JPH04505461A (en) 1992-09-24
AU7189991A (en) 1991-09-03

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Legal Events

Date Code Title Description
FA2A Application withdrawn

Effective date: 19920504