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ES2012578A6 - Procedimiento para preparar la sal de trometamina de 1-metil-beta-oxo-alfa- (fenilcarbamoil)-2-pirrolpropiontrilo. - Google Patents

Procedimiento para preparar la sal de trometamina de 1-metil-beta-oxo-alfa- (fenilcarbamoil)-2-pirrolpropiontrilo.

Info

Publication number
ES2012578A6
ES2012578A6 ES888803830A ES8803830A ES2012578A6 ES 2012578 A6 ES2012578 A6 ES 2012578A6 ES 888803830 A ES888803830 A ES 888803830A ES 8803830 A ES8803830 A ES 8803830A ES 2012578 A6 ES2012578 A6 ES 2012578A6
Authority
ES
Spain
Prior art keywords
oxo
beta
alpha
methyl
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES888803830A
Other languages
English (en)
Inventor
Gordon N Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES2012578A6 publication Critical patent/ES2012578A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR SAL DE TROMETAMINA DE 1-METIL-BETA-OXO-ALFA-(FENILCARBAMOIL)-2-PIRROLPROPIONITRILO, DE FORMULA II
ES888803830A 1987-12-18 1988-12-16 Procedimiento para preparar la sal de trometamina de 1-metil-beta-oxo-alfa- (fenilcarbamoil)-2-pirrolpropiontrilo. Expired - Lifetime ES2012578A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/003413 WO1989005798A1 (en) 1987-12-18 1987-12-18 TROMETHAMINE SALT OF 1-METHYL-beta-OXO-alpha-(PHENYLCARBAMOYL)-2-PYRROLEPROPIONITRILE

Publications (1)

Publication Number Publication Date
ES2012578A6 true ES2012578A6 (es) 1990-04-01

Family

ID=22202723

Family Applications (1)

Application Number Title Priority Date Filing Date
ES888803830A Expired - Lifetime ES2012578A6 (es) 1987-12-18 1988-12-16 Procedimiento para preparar la sal de trometamina de 1-metil-beta-oxo-alfa- (fenilcarbamoil)-2-pirrolpropiontrilo.

Country Status (22)

Country Link
US (1) US4977181A (es)
JP (1) JPH02502534A (es)
KR (1) KR890009868A (es)
AT (1) AT390437B (es)
AU (1) AU3596889A (es)
DD (1) DD283375A5 (es)
DE (1) DE3842250A1 (es)
DK (1) DK704188A (es)
ES (1) ES2012578A6 (es)
FI (1) FI885828L (es)
FR (1) FR2624856A1 (es)
GB (1) GB2211187A (es)
HU (1) HU199788B (es)
IL (1) IL88654A0 (es)
IT (1) IT1235336B (es)
LU (1) LU87406A1 (es)
NL (1) NL8803092A (es)
NO (1) NO885576L (es)
PT (1) PT88104A (es)
WO (1) WO1989005798A1 (es)
YU (1) YU227788A (es)
ZA (1) ZA889355B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058024A1 (es) * 1992-11-10 1994-10-16 Menarini Lab Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02502534A (ja) * 1987-12-18 1990-08-16 チバ‐ガイギー　アクチェンゲゼルシャフト １‐メチル‐β‐オキソ‐α‐（フェニルカルバモイル）‐２‐ピロールプロピオニトリルのトロメタミン塩
US5431717A (en) * 1993-12-03 1995-07-11 Geobiotics, Inc. Method for rendering refractory sulfide ores more susceptible to biooxidation
US7008979B2 (en) 2002-04-30 2006-03-07 Hydromer, Inc. Coating composition for multiple hydrophilic applications
KR100576332B1 (ko) 2004-07-16 2006-05-03 강승우 신규한 글라이세리드 유도체 및 이를 포함하는 통증완화용조성물
SI2854768T1 (sl) 2012-05-30 2017-08-31 Fresenius Kabi Oncology Limited Farmacevtski sestavki pemetrekseda
WO2021233854A1 (en) * 2020-05-20 2021-11-25 F. Hoffmann-La Roche Ag New malonitrile derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4028772A (en) * 1971-04-02 1973-09-27 Merck & Co., Inc Chemical processes
GB1398072A (en) * 1971-06-14 1975-06-18 May & Baker Ltd Cyclopentane derivatives
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4256759A (en) * 1979-06-11 1981-03-17 Ciba-Geigy Corporation Alphacarbamoyl-pyrrolpropionitriles
EP0143142A3 (de) * 1979-06-11 1985-07-17 Ciba-Geigy Ag Alphacarbamoyl-pyrrolpropionitrile, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung
HU185926B (en) * 1979-09-27 1985-04-28 Agostne Kahan Process for preparing water soluble derivatives of non-steroid antiinflammatory compositions and pharmaceutical compositins containing such derivatives
US4644010A (en) * 1982-09-28 1987-02-17 Ciba-Geigy Corporation Certain β-oxo-α-carbamoylpyrrolepropionitriles
JPH02502534A (ja) * 1987-12-18 1990-08-16 チバ‐ガイギー　アクチェンゲゼルシャフト １‐メチル‐β‐オキソ‐α‐（フェニルカルバモイル）‐２‐ピロールプロピオニトリルのトロメタミン塩

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058024A1 (es) * 1992-11-10 1994-10-16 Menarini Lab Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.

Also Published As

Publication number Publication date
GB8829136D0 (en) 1989-01-25
GB2211187A (en) 1989-06-28
IT1235336B (it) 1992-06-30
DK704188D0 (da) 1988-12-16
US4977181A (en) 1990-12-11
HUT48582A (en) 1989-06-28
DK704188A (da) 1989-06-19
YU227788A (en) 1990-08-31
AU3596889A (en) 1990-01-11
IT8848657A0 (it) 1988-12-15
AT390437B (de) 1990-05-10
WO1989005798A1 (en) 1989-06-29
IL88654A0 (en) 1989-07-31
JPH02502534A (ja) 1990-08-16
PT88104A (pt) 1989-09-14
NL8803092A (nl) 1989-07-17
FR2624856A1 (en) 1989-06-23
NO885576L (no) 1989-06-19
ZA889355B (en) 1989-10-25
FI885828A7 (fi) 1989-06-19
ATA307488A (de) 1989-10-15
KR890009868A (ko) 1989-08-04
FI885828A0 (fi) 1988-12-16
LU87406A1 (de) 1990-02-28
FI885828L (fi) 1989-06-19
HU199788B (en) 1990-03-28
DE3842250A1 (de) 1989-06-29
NO885576D0 (no) 1988-12-15
DD283375A5 (de) 1990-10-10

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