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ES2010284A6 - PROCEDURE FOR PREPARING DERIVATIVES OF THIOUREA. - Google Patents

PROCEDURE FOR PREPARING DERIVATIVES OF THIOUREA.

Info

Publication number
ES2010284A6
ES2010284A6 ES8802065A ES8802065A ES2010284A6 ES 2010284 A6 ES2010284 A6 ES 2010284A6 ES 8802065 A ES8802065 A ES 8802065A ES 8802065 A ES8802065 A ES 8802065A ES 2010284 A6 ES2010284 A6 ES 2010284A6
Authority
ES
Spain
Prior art keywords
thiourea
procedure
preparing derivatives
hydrogen
4alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8802065A
Other languages
Spanish (es)
Inventor
Kay Judith Masdin
Christopher S J Walpole
Roger Wrigglesworth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2010284A6 publication Critical patent/ES2010284A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula I < IMAGE > wherein R1 is halogen, C1-4alkyl, phenyl, benzyl, benzyloxy, nitro, cyano, trifluoromethyl, formylamino or C1-16 alkoxy R2 is hydrogen or has any one of the meanings given for R1 R3 is hydrogen or C1-4 alkyl and n is 1 or 2, physiologically-hydrolysable and -acceptable esters and salts thereof are indicated as analgesic and anti-inflammatory agents.
ES8802065A 1987-06-30 1988-06-30 PROCEDURE FOR PREPARING DERIVATIVES OF THIOUREA. Expired ES2010284A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878715357A GB8715357D0 (en) 1987-06-30 1987-06-30 Organic compounds

Publications (1)

Publication Number Publication Date
ES2010284A6 true ES2010284A6 (en) 1989-11-01

Family

ID=10619833

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802065A Expired ES2010284A6 (en) 1987-06-30 1988-06-30 PROCEDURE FOR PREPARING DERIVATIVES OF THIOUREA.

Country Status (16)

Country Link
JP (1) JPS6426551A (en)
KR (1) KR890000417A (en)
AU (1) AU1846488A (en)
DE (1) DE3821317A1 (en)
DK (1) DK356588A (en)
ES (1) ES2010284A6 (en)
FI (1) FI883097A7 (en)
FR (1) FR2617477A1 (en)
GB (2) GB8715357D0 (en)
IL (1) IL86890A0 (en)
IT (1) IT1219676B (en)
LU (1) LU87261A1 (en)
NL (1) NL8801659A (en)
PT (1) PT87854B (en)
SE (1) SE8802412L (en)
ZA (1) ZA884693B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5099030A (en) * 1987-03-09 1992-03-24 The Procter & Gamble Company Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain
US5045565A (en) * 1987-03-09 1991-09-03 The Procter & Gamble Company Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain
US5461075A (en) * 1988-06-17 1995-10-24 The Procter & Gamble Company Use of vanilloids for the prevention of lesions due to herpes simplex infections
GR880100400A (en) * 1988-06-21 1990-05-11 Sandoz Ag Thiourea derivatives
HU206082B (en) * 1988-12-23 1992-08-28 Sandoz Ag Process for producing capsaicin derivatives and pharmaceutical compositions comprising such compounds
US5403868A (en) * 1988-12-23 1995-04-04 Sandoz Ltd. Capsaicin derivatives
HU210683B (en) * 1990-06-18 1995-06-28 Sandoz Ag Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same
TW476996B (en) 2000-02-28 2002-02-21 Mitsubishi Material Silicon Semiconductor manufacturing method and semiconductor manufacturing apparatus
US6313172B1 (en) * 2000-04-13 2001-11-06 Allergan Sales, Inc. Methods and compositions for modulating alpha adrenergic receptor activity
US6545182B2 (en) * 2000-04-13 2003-04-08 Allergan Sales, Inc. Methods and compositions for modulating alpha adrenergic receptor activity
KR100453078B1 (en) * 2000-08-21 2004-10-15 주식회사 태평양 Novel thiourea compounds and the pharmaceutical compositions containing the same
JP5001505B2 (en) * 2000-08-21 2012-08-15 株式會社アモーレパシフィック Novel thiourea derivative and pharmaceutical composition containing the same
ITMI20041231A1 (en) * 2004-06-18 2004-09-18 Pharmeste Srl VANILLOID RECEPTOR ANTAGONISTS TRPV1
EP1939173A1 (en) * 2006-12-21 2008-07-02 Pharmeste S.r.l. O-substituted-dibenzyl urea- or thiourea- derivatives as trpv1 receptor antagonists

Also Published As

Publication number Publication date
IT1219676B (en) 1990-05-24
KR890000417A (en) 1989-03-14
IT8848132A0 (en) 1988-06-28
DK356588A (en) 1988-12-31
LU87261A1 (en) 1989-03-08
AU1846488A (en) 1989-01-05
NL8801659A (en) 1989-01-16
ZA884693B (en) 1990-03-28
FI883097A7 (en) 1988-12-31
SE8802412D0 (en) 1988-06-28
JPS6426551A (en) 1989-01-27
GB2206347A (en) 1989-01-05
GB8715357D0 (en) 1987-08-05
FR2617477A1 (en) 1989-01-06
DE3821317A1 (en) 1989-01-12
IL86890A0 (en) 1988-11-30
SE8802412L (en) 1988-12-31
PT87854A (en) 1988-07-01
FI883097A0 (en) 1988-06-28
DK356588D0 (en) 1988-06-28
GB8815258D0 (en) 1988-08-03
PT87854B (en) 1992-10-30

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