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ES2010114A6 - Procedimiento de preparacion de derivados de los acidos 1,4-dihidro-4-oxoquinolein-3-carboxilicos. - Google Patents

Procedimiento de preparacion de derivados de los acidos 1,4-dihidro-4-oxoquinolein-3-carboxilicos.

Info

Publication number
ES2010114A6
ES2010114A6 ES8900318A ES8900318A ES2010114A6 ES 2010114 A6 ES2010114 A6 ES 2010114A6 ES 8900318 A ES8900318 A ES 8900318A ES 8900318 A ES8900318 A ES 8900318A ES 2010114 A6 ES2010114 A6 ES 2010114A6
Authority
ES
Spain
Prior art keywords
dihydro
preparation
oxoquinoline
azetidinyl
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8900318A
Other languages
English (en)
Inventor
Juan Pares Corominas
Jordi Frigola Constansa
Pinol Augusto Colombo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8718289A external-priority patent/FR2625200A1/fr
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2010114A6 publication Critical patent/ES2010114A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE LOS ACIDOS 1,4-DIHIDRO-4-OXOQUINOLEIN-3-CARBOXILICOS QUE RESPONDEN A LA FORMULA GENERAL (I) EN EL QUE SE HACE REACCIONAR UN COMPUESTO HETEROCICLICO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) ESTANDO LOS SIGNIFICADOS EXPLICADOS EN EL TEXTO. LOS COMPUESTOS PREPARADOS SEGUN LA INVENCION SON APLICABLES PARA EL TRATAMIENTO DE INFECCIONES CAUSADAS POR MICROORGANISMOS GRAM-POSITIVOS Y GRAM-NEGATIVOS.
ES8900318A 1987-12-29 1988-12-28 Procedimiento de preparacion de derivados de los acidos 1,4-dihidro-4-oxoquinolein-3-carboxilicos. Expired ES2010114A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8718289A FR2625200A1 (en) 1987-12-29 1987-12-29 7-(1-Azetidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their application as medicaments
FR888809816A FR2634483B2 (fr) 1987-12-29 1988-07-20 Derives des acides 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoleine-3-carboxyliques, leur preparation et leur application en tant que medicaments

Publications (1)

Publication Number Publication Date
ES2010114A6 true ES2010114A6 (es) 1989-10-16

Family

ID=26226417

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8900318A Expired ES2010114A6 (es) 1987-12-29 1988-12-28 Procedimiento de preparacion de derivados de los acidos 1,4-dihidro-4-oxoquinolein-3-carboxilicos.

Country Status (14)

Country Link
US (1) US4927926A (es)
EP (1) EP0324298B1 (es)
JP (1) JPH0813811B2 (es)
KR (1) KR920004136B1 (es)
AU (1) AU617735B2 (es)
DE (1) DE3876969T2 (es)
DK (1) DK726188A (es)
ES (1) ES2010114A6 (es)
FR (1) FR2634483B2 (es)
GR (1) GR3006664T3 (es)
HU (1) HU206206B (es)
NO (1) NO176605C (es)
PT (1) PT89352B (es)
YU (1) YU47124B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839355A (en) * 1987-09-09 1989-06-13 Sterling Drug Inc. Tricyclic-pyridinylquinoline compounds, their preparation and use
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
DE3814517A1 (de) * 1988-02-05 1989-08-17 Bayer Ag Chinolon- und naphthyridoncarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende antibakterielle mittel und futterzusatzstoffe
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
EP0997466A1 (en) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
FR2649106A2 (fr) * 1989-06-29 1991-01-04 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament
FR2644455B1 (fr) * 1989-03-16 1994-09-23 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicaments
FR2654728B2 (fr) * 1989-03-16 1994-09-23 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament.
NO177302C (no) * 1989-03-16 1995-08-23 Esteve Labor Dr Analogifremgangsmåte til fremstilling av terapeutisk aktive substituerte azetidinylkinolon(naftyridon)karboksylsyrederivater
IE912902A1 (en) * 1990-08-24 1992-02-26 Abbott Lab Quinbenzoxazine, quinobenzothiazine, and pyrido-acridine¹antineoplastic agents
FR2676445B1 (fr) * 1991-05-16 1995-02-03 Esteve Labor Dr Derives de pyridone amino acide azetidinyl substitues, leur preparation et leur application en tant que medicaments.
US5556861A (en) * 1991-10-01 1996-09-17 Laboratoire Roger Bellon 1,8 benzonaphthyridine derivatives and antimicrobial compositions
FR2690161B1 (fr) * 1992-04-16 1995-06-30 Esteve Labor Dr Derives de pyridone azetidinyl substitues avec activite antimicrobienne.
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
JP2005097116A (ja) * 1999-11-11 2005-04-14 Wakunaga Pharmaceut Co Ltd キノリンカルボン酸誘導体アルカリ金属塩及びこれを用いたキノリンカルボン酸誘導体の精製法
WO2005026146A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Azetidinyl quinolones as antibacterial agents
JP2008508359A (ja) * 2004-08-02 2008-03-21 グラクソ グループ リミテッド 抗菌剤
WO2013080036A1 (en) 2011-12-01 2013-06-06 Purdue Pharma L.P. Azetidine-substituted quinoxaline-type piperidine compounds and uses thereof
BR112015008515A2 (pt) 2012-10-16 2017-07-04 Janssen Pharmaceutica Nv moduladores de ror t de quinolinila ligada à heteroarila
AU2013331496B2 (en) 2012-10-16 2017-07-27 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of ROR-gamma-t
CA2888485C (en) 2012-10-16 2021-01-26 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of ror.gamma.t
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
JP6423423B2 (ja) 2013-10-15 2018-11-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｒｏｒγｔのアルキル結合キノリニルモジュレーター
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
EP3057422B1 (en) 2013-10-15 2019-05-15 Janssen Pharmaceutica NV Quinolinyl modulators of ror(gamma)t
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
EP4236928A4 (en) * 2020-10-30 2024-08-28 1Cbio, Inc. ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP1) INHIBITORS AND THEIR USES
CN113045539B (zh) * 2021-03-30 2021-12-07 苏州大学 2-(4,4-二氯-1-(8-喹啉基)-2-氮杂环丁基)羧酸酯衍生物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
US4540690A (en) * 1982-02-09 1985-09-10 The Upjohn Company 2-(Phenylmethylene)cycloalkylamines and -azetidines
US4777175A (en) * 1982-09-09 1988-10-11 Warner-Lambert Company Antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
JPS6089480A (ja) * 1983-10-21 1985-05-20 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体
JPS60126284A (ja) * 1983-12-09 1985-07-05 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体およびその塩
JPH0665676B2 (ja) * 1984-04-26 1994-08-24 アボツト ラボラトリーズ キノリン‐ベノキサジン抗菌性化合物
US4588263A (en) * 1984-05-02 1986-05-13 International Business Machines Corporation An adjustable-optical prism with integral-polarizing beam splitter and applications thereof
JPS61137885A (ja) * 1984-12-08 1986-06-25 Dainippon Pharmaceut Co Ltd １，８−ナフチリジン誘導体、そのエステルおよびその塩
US4617308A (en) * 1985-01-25 1986-10-14 Warner-Lambert Company 7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents
NO871333L (no) * 1986-03-31 1987-10-01 Sankyo Co Kinolin-3-karboksylsyrederivater, fremgangsmaate til fremstilling og anvendelse derav.
US5039683A (en) * 1987-10-26 1991-08-13 Pfizer Inc. Azetidinyl quinolone carboxylic acids and esters
AU603936B2 (en) * 1988-02-04 1990-11-29 Chenault D. Lee Disposable vaginal speculum

Also Published As

Publication number Publication date
NO176605B (no) 1995-01-23
FR2634483B2 (fr) 1994-03-04
DE3876969T2 (de) 1993-05-19
NO885797L (no) 1989-06-30
NO176605C (no) 1995-05-03
JPH0813811B2 (ja) 1996-02-14
KR920004136B1 (ko) 1992-05-25
PT89352B (pt) 1993-09-30
AU617735B2 (en) 1991-12-05
US4927926A (en) 1990-05-22
AU2757888A (en) 1989-06-29
YU237088A (en) 1990-12-31
PT89352A (pt) 1989-12-29
EP0324298A1 (fr) 1989-07-19
YU47124B (sh) 1994-12-28
DE3876969D1 (de) 1993-02-04
FR2634483A2 (fr) 1990-01-26
EP0324298B1 (fr) 1992-12-23
DK726188A (da) 1989-06-30
DK726188D0 (da) 1988-12-28
GR3006664T3 (es) 1993-06-30
NO885797D0 (no) 1988-12-28
HU206206B (en) 1992-09-28
KR890009911A (ko) 1989-08-04
JPH01301677A (ja) 1989-12-05
HUT50467A (en) 1990-02-28

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2008-12-28