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ES2010104A6 - Procedimiento de preparacion de ureas asimetricas y utilizacion de las mismas. - Google Patents

Procedimiento de preparacion de ureas asimetricas y utilizacion de las mismas.

Info

Publication number
ES2010104A6
ES2010104A6 ES8900264A ES8900264A ES2010104A6 ES 2010104 A6 ES2010104 A6 ES 2010104A6 ES 8900264 A ES8900264 A ES 8900264A ES 8900264 A ES8900264 A ES 8900264A ES 2010104 A6 ES2010104 A6 ES 2010104A6
Authority
ES
Spain
Prior art keywords
preparation
nitrogen
ureas
asymmetrical
utilization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8900264A
Other languages
English (en)
Inventor
Meseguer Jose Diago
Bianchini Asuncion Esteve
Padro Carlos E Lenhardt
Pitarch Esteve Sans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Industrial Products SA
Original Assignee
Gema SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gema SA filed Critical Gema SA
Priority to ES8900264A priority Critical patent/ES2010104A6/es
Publication of ES2010104A6 publication Critical patent/ES2010104A6/es
Priority to EP90902257A priority patent/EP0594563A1/en
Priority to JP2502612A priority patent/JPH03503770A/ja
Priority to PCT/ES1990/000003 priority patent/WO1990008764A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UREAS ASIMETRICAS Y UTILIZACION DE LAS MISMAS, DE FORMULA DONDE R2 Y R3, IGUALES O DISTINTOS, SIGNIFICAN UN ATOMO DE HIDROGENO O UNA FRACCION ESTRUCTURAL SUSCEPTIBLE DE ESTAR ENLAZADA A UN ATOMO DE NITROGENO, APTA PARA FORMAR PARTE DE UN ANILLO DONDE EL NITROGENO ES UN ESLABON Y CON LA EXCEPCION QUE HN-R3-R2 SEA LA 4-ETIL-2,3-DIOXOPIPERACINA, EL PROCEDIMIENTO SE BASA EN LA REACCION DE UN PRIMER COMPUESTO ELEGIDO DENTRO DEL GRUPO CONSISTENTE EN CLORURO DE CARBONILO, DIFOSGENO Y UN CLOROFORMIATO ACTIVO CON UN EQUIVALENTE DE UN COMPUESTO NITROGENADO DE FORMULA Y CON UN EQUIVALENTE DE UN SEGUNDO COMPUESTO ELEGIDO DENTRO DEL GRUPO FORMADO POR 4-ETIL-2,3-DIOXOPIPERACINA Y UN DERIVADO TRIMETILSILICICO DEL MISMO. LAS UREAS ASIMETRICAS SON DE UTILIZACION PARA PREPARACION DE AMIDAS DE GRAN INTERES COMO ANTIBIOTICOS BETALACTAMICOS O COMO INTERMEDIOS PARA PREPARACION DE ESTOS ULTIMOS.
ES8900264A 1989-01-26 1989-01-26 Procedimiento de preparacion de ureas asimetricas y utilizacion de las mismas. Expired ES2010104A6 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES8900264A ES2010104A6 (es) 1989-01-26 1989-01-26 Procedimiento de preparacion de ureas asimetricas y utilizacion de las mismas.
EP90902257A EP0594563A1 (en) 1989-01-26 1990-01-23 Asymmetrical ureas, method for the preparation and utilization of the same
JP2502612A JPH03503770A (ja) 1989-01-26 1990-01-23 非対称尿素、その製造方法及び使用方法
PCT/ES1990/000003 WO1990008764A1 (es) 1989-01-26 1990-01-23 Ureas asimetricas, procedimiento de preparacion y utilizacion de las mismas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8900264A ES2010104A6 (es) 1989-01-26 1989-01-26 Procedimiento de preparacion de ureas asimetricas y utilizacion de las mismas.

Publications (1)

Publication Number Publication Date
ES2010104A6 true ES2010104A6 (es) 1989-10-16

Family

ID=8260066

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8900264A Expired ES2010104A6 (es) 1989-01-26 1989-01-26 Procedimiento de preparacion de ureas asimetricas y utilizacion de las mismas.

Country Status (4)

Country Link
EP (1) EP0594563A1 (es)
JP (1) JPH03503770A (es)
ES (1) ES2010104A6 (es)
WO (1) WO1990008764A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101508679B (zh) * 2009-03-31 2010-05-12 山西新天源医药化工有限公司 D(-)-α-(4-乙基-2,3-双氧哌嗪-1-甲酰胺基)对羟基苯乙酸的合成方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2562371A1 (en) * 2004-04-09 2005-10-20 Neuromed Pharmaceuticals Ltd. Diarylamine derivatives as calcium channel blockers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3479731D1 (en) * 1983-07-07 1989-10-19 Beecham Group Plc Substituted phenylglycine derivatives of beta-lactam antibiotics
DE3619562A1 (de) * 1986-06-11 1987-12-17 Basf Ag Verfahren zur herstellung von 2,3-dioxo-4-oxicarbonylpiperazinderivaten, neue 2,3-dioxo-4-oxicarbonylpiperazinderivate und deren verwendung
ES2005450A6 (es) * 1987-11-16 1989-03-01 Gema Sa Procedimiento para la preparacion de derivados n(4-etil-2,3-dioxo)-piperacin-1-iln-carbonilo.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101508679B (zh) * 2009-03-31 2010-05-12 山西新天源医药化工有限公司 D(-)-α-(4-乙基-2,3-双氧哌嗪-1-甲酰胺基)对羟基苯乙酸的合成方法

Also Published As

Publication number Publication date
JPH03503770A (ja) 1991-08-22
WO1990008764A1 (es) 1990-08-09
EP0594563A1 (en) 1994-05-04

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Legal Events

Date Code Title Description
PC1A Transfer granted

Owner name: BIOCHEMIE S.A.

FD1A Patent lapsed

Effective date: 20000201