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ES2009949A6 - New derivatives of aryl heteroaryl ketones, process for preparing them as well as their application as medicinal product - Google Patents

New derivatives of aryl heteroaryl ketones, process for preparing them as well as their application as medicinal product

Info

Publication number
ES2009949A6
ES2009949A6 ES8802032A ES8802032A ES2009949A6 ES 2009949 A6 ES2009949 A6 ES 2009949A6 ES 8802032 A ES8802032 A ES 8802032A ES 8802032 A ES8802032 A ES 8802032A ES 2009949 A6 ES2009949 A6 ES 2009949A6
Authority
ES
Spain
Prior art keywords
radical
preparing
well
application
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8802032A
Other languages
Spanish (es)
Inventor
Pinol Augusto Colombo
Corominas Juan Pares
Constansa Jordi Frigola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2009949A6 publication Critical patent/ES2009949A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS DE ARIL-HETEROARILCETONAS, QUE RESPONDEN A LA FORMULA GENERAL (I), EN LA CUAL: R1 A R3, IDENTICOS O DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO, UN HALOGENO, UN RADICAL ALQUILO, UN GRUPO ARILO, UN RADICAL ALCOXI, UN RADICAL NITRO, UN RADICAL AMINO O UN RADICAL CIANO; HET REPRESENTA UN AZOL. EL PROCEDIMIENTO INCLUYE CONDENSAR UN COMPUESTO DE LA FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III) LOS NUEVOS DERIVADOS SON APROPIADOS PARA PREVENIR O TRATAR EL DOLOR DE INTENSIDAD MEDIA O FUERTE.PROCEDURE FOR THE PREPARATION OF NEW ARIL-HETEROARYL KETONE DERIVATIVES, RESPONDING TO THE GENERAL FORMULA (I), IN WHICH: R1 TO R3, IDENTICAL OR DIFFERENT, REPRESENT AN ATOMO OF HYDROGEN, A HALOGEN, A RADICAL ALKYL, A A RADICAL ALCOXI, A RADICAL NITRO, A RADICAL AMINO OR A RADICAL CIANO; HET REPRESENTS AN AZOL. THE PROCEDURE INCLUDES CONDENSING A COMPOUND OF THE GENERAL FORMULA (II) WITH A COMPOUND OF THE GENERAL FORMULA (III) THE NEW DERIVATIVES ARE APPROPRIATE TO PREVENT OR TREAT MEDIUM OR STRONG PAIN PAIN.

ES8802032A 1987-07-01 1988-06-29 New derivatives of aryl heteroaryl ketones, process for preparing them as well as their application as medicinal product Expired ES2009949A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8709301A FR2617478B1 (en) 1987-07-01 1987-07-01 NOVEL ARYL-HETEROARYL CETONES DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS

Publications (1)

Publication Number Publication Date
ES2009949A6 true ES2009949A6 (en) 1989-10-16

Family

ID=9352739

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802032A Expired ES2009949A6 (en) 1987-07-01 1988-06-29 New derivatives of aryl heteroaryl ketones, process for preparing them as well as their application as medicinal product

Country Status (2)

Country Link
ES (1) ES2009949A6 (en)
FR (1) FR2617478B1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4546589B2 (en) * 1998-04-23 2010-09-15 武田薬品工業株式会社 Naphthalene derivatives
WO1999054309A1 (en) * 1998-04-23 1999-10-28 Takeda Chemical Industries, Ltd. Naphthalene derivatives, their production and use
KR101605210B1 (en) 2007-06-21 2016-03-21 케러 테라퓨틱스, 인코포레이티드 Substituted imidazoheterocycles
US8859538B2 (en) 2007-06-21 2014-10-14 Cara Therapeutics, Inc. Uses of substituted imidazoheterocycles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT227693B (en) * 1960-11-23 1963-06-10 Donau Pharmazie Gmbh Process for the preparation of new, 1-substituted 2- (α-oxo-aralkyl) -benzimidazoles
BE788548A (en) * 1971-09-10 1973-03-08 Bayer Ag NEW 2-IMIDAZOLYL-CARBONYL-BENZOIC ACIDS, THEIR ESTERS AND THEIR SALTS, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS PLANT GROWTH REGULATORS
US4194049A (en) * 1979-03-29 1980-03-18 Hoffmann-La Roche Inc. 2-[[2-Methyl-1-[2-benzoyl(or benzyl)phenyl]-1H-imidazol-5-yl]methyl]-1H-isoindole-1,3(2H)-diones
GR78209B (en) * 1982-04-15 1984-09-26 May & Baker Ltd

Also Published As

Publication number Publication date
FR2617478A1 (en) 1989-01-06
FR2617478B1 (en) 1990-01-05

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