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ES2009236A6 - 4-(2-Pyrimidinyl)-piperazine derivatives - Google Patents

4-(2-Pyrimidinyl)-piperazine derivatives

Info

Publication number
ES2009236A6
ES2009236A6 ES8800543A ES8800543A ES2009236A6 ES 2009236 A6 ES2009236 A6 ES 2009236A6 ES 8800543 A ES8800543 A ES 8800543A ES 8800543 A ES8800543 A ES 8800543A ES 2009236 A6 ES2009236 A6 ES 2009236A6
Authority
ES
Spain
Prior art keywords
formula
compound
pyrimidinyl
anxioselective
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800543A
Other languages
Spanish (es)
Inventor
Zoltan Budai
Livia Gregor
Tibor Mezei
Klara Reiter
Eva Judit Tajhy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU71787A external-priority patent/HU198204B/en
Priority claimed from HU71887A external-priority patent/HU198477B/en
Priority claimed from HU71687A external-priority patent/HU197313B/en
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES2009236A6 publication Critical patent/ES2009236A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a new and improved process for the preparation of 8-{4-[4-(2-pyrimidinyl)--1- piperazinyl]-butyl}-8-aza-spiro[4.5]decane-7,9--dione of the Formula I < IMAGE > and pharmaceutically acceptable acid addition salts thereof, which comprises hydrogenating a compound of the general Formula II < IMAGE > (wherein A stands for -C IDENTICAL C- or CH=CH-) and, if desired, converting the compound of the Formula I thus obtained into a pharmaceuticaily acceptable acid additfon salt thereof. The compound of the Formula I is a known anxioselective agent. The invention also relates to intermediates of Formula II used in the above process and a method for the preparation thereof. These compounds also have anxioselective action.
ES8800543A 1987-02-25 1988-02-25 4-(2-Pyrimidinyl)-piperazine derivatives Expired ES2009236A6 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU71787A HU198204B (en) 1987-02-25 1987-02-25 Process for production of derivatives of piperasine
HU71887A HU198477B (en) 1987-02-25 1987-02-25 Process for producing pyrimidinyl piperazine derivatives
HU71687A HU197313B (en) 1987-02-25 1987-02-25 Process for producing 8-azaspiro <4.5> decane-7,9-dione-8-propine-/2/

Publications (1)

Publication Number Publication Date
ES2009236A6 true ES2009236A6 (en) 1989-09-16

Family

ID=27269942

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800543A Expired ES2009236A6 (en) 1987-02-25 1988-02-25 4-(2-Pyrimidinyl)-piperazine derivatives

Country Status (20)

Country Link
KR (1) KR880009955A (en)
CN (1) CN88100923A (en)
AT (1) AT395851B (en)
BE (1) BE1001464A3 (en)
CA (1) CA1300141C (en)
CH (1) CH677924A5 (en)
CS (1) CS274423B2 (en)
DE (1) DE3806009C2 (en)
DK (1) DK99388A (en)
ES (1) ES2009236A6 (en)
FI (1) FI880895A7 (en)
FR (1) FR2615853B1 (en)
GB (1) GB2201417B (en)
GR (1) GR1002245B (en)
IL (1) IL85545A (en)
IT (1) IT1217342B (en)
NL (1) NL8800484A (en)
PL (1) PL152958B1 (en)
SE (1) SE8800651L (en)
YU (1) YU46441B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU217129B (en) * 1993-07-16 1999-11-29 EGIS Gyógyszergyár Rt. Process for the preparation of buspiron as therapeutical active ingredient of high purity
KR950014099A (en) * 1993-11-10 1995-06-15 장기하 Method for preparing N- (2-pyrimidyl) piperazinyl butylamide
CN119409681B (en) * 2024-03-28 2025-12-16 北京华素制药股份有限公司 Preparation method of buspirone hydrochloride

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE300422B (en) * 1964-07-03 1968-04-29 Astra Ab
DE1545543B1 (en) * 1964-07-03 1970-01-22 Astra Apotekarnes Kem Fab 4-aminobutinylimides, their salts and processes for their preparation
US3354178A (en) * 1965-04-09 1967-11-21 Sterling Drug Inc Nu-(4-amino-2-butynyl)-nu-alkylcarboxamides
BE759371A (en) * 1969-11-24 1971-05-24 Bristol Myers Co HETEROCYCLICAL AZASPIRODECANEDIONES AND METHODS FOR THEIR PREPARATION
JPS6310786A (en) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd Novel imide derivative and production thereof
JPS6310760A (en) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd Novel production of imide derivative

Also Published As

Publication number Publication date
KR880009955A (en) 1988-10-06
IL85545A0 (en) 1988-08-31
GB8804385D0 (en) 1988-03-23
GR880100108A (en) 1988-12-16
DE3806009C2 (en) 1996-09-12
SE8800651L (en) 1988-08-26
GB2201417B (en) 1990-10-31
SE8800651D0 (en) 1988-02-25
YU36288A (en) 1989-10-31
CS274423B2 (en) 1991-04-11
CS122288A2 (en) 1990-08-14
IT8819545A0 (en) 1988-02-25
ATA47688A (en) 1992-08-15
GB2201417A (en) 1988-09-01
CA1300141C (en) 1992-05-05
NL8800484A (en) 1988-09-16
IT1217342B (en) 1990-03-22
FR2615853A1 (en) 1988-12-02
IL85545A (en) 1992-05-25
PL152958B1 (en) 1991-02-28
YU46441B (en) 1993-10-20
BE1001464A3 (en) 1989-11-07
CH677924A5 (en) 1991-07-15
DE3806009A1 (en) 1988-09-08
AT395851B (en) 1993-03-25
CN88100923A (en) 1988-09-28
GR1002245B (en) 1996-04-22
DK99388D0 (en) 1988-02-25
FI880895A7 (en) 1988-08-26
PL270815A1 (en) 1989-04-03
FI880895A0 (en) 1988-02-25
DK99388A (en) 1988-08-26
FR2615853B1 (en) 1991-01-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000301