ES2003112A6 - Un procedimiento para la preparacion de un decapeptido. - Google Patents
Un procedimiento para la preparacion de un decapeptido.Info
- Publication number
- ES2003112A6 ES2003112A6 ES8602274A ES8602274A ES2003112A6 ES 2003112 A6 ES2003112 A6 ES 2003112A6 ES 8602274 A ES8602274 A ES 8602274A ES 8602274 A ES8602274 A ES 8602274A ES 2003112 A6 ES2003112 A6 ES 2003112A6
- Authority
- ES
- Spain
- Prior art keywords
- neurokinin
- solutions containing
- peptide antagonists
- opthalmic solutions
- decapeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NHXYSAFTNPANFK-HDMCBQFHSA-N Neurokinin B Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(O)=O)C1=CC=CC=C1 NHXYSAFTNPANFK-HDMCBQFHSA-N 0.000 title abstract 3
- 102000046798 Neurokinin B Human genes 0.000 title abstract 3
- 101800002813 Neurokinin-B Proteins 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- -1 D-Asp amino acids Chemical class 0.000 abstract 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
EL DECAPEPTIDO DE FORMULA (I): A1-D-PRO2-HIS3-D4-PHE5-D-TRP6-VAL7-D-TRP8-LEU9-NLE10-NH2FF(I) DONDE A1 ES ASP1 O D-ASP1 Y D4 ES ASP4 O D)ASP4 Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, SE OBTIENE HACIENDO REACCIONAR JUNTOS Y EN CUALQUIER ORDEN QUE SE DESEE LOS AMINOACIDOS INDIVIDUALES 1 A 10 ANTES SEÑALADOS. ESTOS DECAPEPTIDOS SON ANALGESICOS Y EJERCEN ACTIVIDAD ANTAGONISTA DE LA NEUROQUININA B QUE TAMBIEN ES CONOCIDA COMO NEUROMEDINA K. DICHOS DECAPEPTIDOS SON UTILES PARA LA OBTENCION DE SOLUCIONES OFTALMICAS PARA EL TRATAMIENTO DEL DOLOR O LA INFLAMACION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/781,839 US4665157A (en) | 1985-09-30 | 1985-09-30 | Peptide antagonists of neurokinin B |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2003112A6 true ES2003112A6 (es) | 1988-10-16 |
Family
ID=25124115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8602274A Expired ES2003112A6 (es) | 1985-09-30 | 1986-09-29 | Un procedimiento para la preparacion de un decapeptido. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4665157A (es) |
| EP (1) | EP0219258A3 (es) |
| JP (1) | JPS62123198A (es) |
| AU (1) | AU587285B2 (es) |
| CA (1) | CA1291592C (es) |
| DK (1) | DK464986A (es) |
| ES (1) | ES2003112A6 (es) |
| GR (1) | GR862451B (es) |
| ZA (1) | ZA867423B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4742156A (en) * | 1985-09-30 | 1988-05-03 | Mcneilab, Inc. | Peptide antagonists of neurokinin B and opthalmic solutions containing them |
| US4665157A (en) * | 1985-09-30 | 1987-05-12 | Mcneilab, Inc. | Peptide antagonists of neurokinin B |
| US5331089A (en) * | 1988-03-25 | 1994-07-19 | Merck Sharpe & Dohme, Ltd. | Peptides useful as tachykinin agonists |
| DE3813124A1 (de) * | 1988-04-15 | 1989-10-26 | Krieg Benno | Destillierbare pufferloesungen und ihre anwendungen |
| US5830863A (en) * | 1988-06-20 | 1998-11-03 | Merrell Pharmaceuticals Inc. | Neurokinin A antagonists |
| US6218364B1 (en) | 1988-06-20 | 2001-04-17 | Scott L. Harbeson | Fluorinated neurokinin A antagonists |
| IT1233696B (it) * | 1989-05-29 | 1992-04-14 | Menarini Farma Ind | Peptidi di sintesi antagonisti della neurochinina a. loro sali e relativi procedimenti di fabbricazione |
| AU638264B2 (en) * | 1989-08-10 | 1993-06-24 | Aventis Inc. | Cyclic neurokinin a antagonists |
| US5374621A (en) * | 1991-09-13 | 1994-12-20 | Regents Of The University Of California | Neurotensin method for inhibiting vascular leakage |
| US5328927A (en) * | 1992-03-03 | 1994-07-12 | Merck Sharpe & Dohme, Ltd. | Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them |
| GB9927125D0 (en) | 1999-11-16 | 2000-01-12 | Univ Reading The | Placental human neurokinin B precursor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4481190A (en) * | 1982-12-21 | 1984-11-06 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| US4481139A (en) * | 1983-04-13 | 1984-11-06 | Board Of Regents, The University Of Texas System | Peptide antagonists of substance P |
| US4665157A (en) * | 1985-09-30 | 1987-05-12 | Mcneilab, Inc. | Peptide antagonists of neurokinin B |
-
1985
- 1985-09-30 US US06/781,839 patent/US4665157A/en not_active Expired - Lifetime
-
1986
- 1986-09-26 GR GR862451A patent/GR862451B/el unknown
- 1986-09-29 ZA ZA867423A patent/ZA867423B/xx unknown
- 1986-09-29 DK DK464986A patent/DK464986A/da not_active Application Discontinuation
- 1986-09-29 EP EP86307446A patent/EP0219258A3/en not_active Withdrawn
- 1986-09-29 AU AU63214/86A patent/AU587285B2/en not_active Expired - Fee Related
- 1986-09-29 ES ES8602274A patent/ES2003112A6/es not_active Expired
- 1986-09-29 CA CA000519316A patent/CA1291592C/en not_active Expired - Lifetime
- 1986-09-30 JP JP61230195A patent/JPS62123198A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0219258A2 (en) | 1987-04-22 |
| JPS62123198A (ja) | 1987-06-04 |
| ZA867423B (en) | 1988-04-27 |
| DK464986D0 (da) | 1986-09-29 |
| GR862451B (en) | 1987-02-03 |
| AU587285B2 (en) | 1989-08-10 |
| CA1291592C (en) | 1991-10-29 |
| EP0219258A3 (en) | 1988-12-21 |
| AU6321486A (en) | 1987-04-02 |
| DK464986A (da) | 1987-03-31 |
| US4665157A (en) | 1987-05-12 |
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