[go: up one dir, main page]

ES2002110A6 - Procedimiento para la preparacion de derivados de resorufina. - Google Patents

Procedimiento para la preparacion de derivados de resorufina.

Info

Publication number
ES2002110A6
ES2002110A6 ES8600580A ES8600580A ES2002110A6 ES 2002110 A6 ES2002110 A6 ES 2002110A6 ES 8600580 A ES8600580 A ES 8600580A ES 8600580 A ES8600580 A ES 8600580A ES 2002110 A6 ES2002110 A6 ES 2002110A6
Authority
ES
Spain
Prior art keywords
carboxamido
cyano
carboxyl
derivatives
case
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600580A
Other languages
English (en)
Inventor
Christian Klein
Hans Georg Batz
Rupert Herrmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES2002110A6 publication Critical patent/ES2002110A6/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE REIVINDICA UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE RESORUFINA DE FORMULAS GENERALES IA Y IB EN LOS CUALES R.1, R.2, R.3 Y R.5, QUE PUEDEN SER EN CADA CASO IGUALES O DISTINTOS, SIGNIFICAN HIDROGENO, UN GRUPO CARBOXI, CARBOXAMIDO, ALCOXI INFERIOR-CARBONILO, CIANO O NITRO, UN RADICAL ALQUILO INFERIOR O ALCOXI INFERIOR, QUE EN CADA CASO PUEDEN ESTAR SUSTITUIDOS CON GRUPOS CARBOXI, CARBOXAMIDO, ALCOXI INFERIOR-CARBONILO, CIANO O NITRO, PUDIENDO REPRESENTAR R.4 Y R.5, EN COMUN, UN COMPUESTO AROMATICO CONDENSADO, Z SIGNIFICA UN MIEMBRO DE PUENTE, A SIGNIFICA EL RADICAL DE UN LIGANDO Y N SIGNIFICA UN NUMERO ENTERO DE 1 A 200. SU PREPARACION SE EFECTUA EN VARIAS ETAPAS A TRAVES DE DERIVADOS REACTIVOS DE TRIACILDIHIORORRESORUFINA, QUE O BIEN SE HACEN REACCIONAR DIRECTAMENTE CON LIGANDOS REACTIVOS O ANALOGOS O LIGANDOS, O PUEDEN SER UNIDOS CON ESTOS A TRAVES DE SU ESPACIADOR.
ES8600580A 1985-07-25 1986-07-24 Procedimiento para la preparacion de derivados de resorufina. Expired ES2002110A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853526565 DE3526565A1 (de) 1985-07-25 1985-07-25 Resorufin-derivate, verfahren zu deren herstellung sowie deren verwendung in fluoreszenzimmunoassays

Publications (1)

Publication Number Publication Date
ES2002110A6 true ES2002110A6 (es) 1988-07-16

Family

ID=6276697

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600580A Expired ES2002110A6 (es) 1985-07-25 1986-07-24 Procedimiento para la preparacion de derivados de resorufina.

Country Status (11)

Country Link
US (2) US4954630A (es)
EP (1) EP0209875B1 (es)
JP (3) JPS6236368A (es)
KR (1) KR870001184A (es)
AT (1) ATE55998T1 (es)
CA (1) CA1338320C (es)
CS (1) CS273617B2 (es)
DE (2) DE3526565A1 (es)
ES (1) ES2002110A6 (es)
SU (1) SU1621811A3 (es)
YU (1) YU45348B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319620A1 (en) * 1987-12-10 1989-06-14 Viomedics Inc. Novel oxazines-ureas and thiazine urea chromophors
DE3526565A1 (de) * 1985-07-25 1987-02-05 Boehringer Mannheim Gmbh Resorufin-derivate, verfahren zu deren herstellung sowie deren verwendung in fluoreszenzimmunoassays
DE3644401A1 (de) * 1986-12-24 1988-07-07 Boehringer Mannheim Gmbh Neue hydrolase-substrate
JPH01211595A (ja) * 1988-02-18 1989-08-24 Kikkoman Corp 新規Ｎ−アセチル−β−Ｄ−グルコサミン誘導体、その製法及びＮ−アセチル−β−Ｄ−グルコサミニダーゼ活性測定用試薬への利用
CA2227448C (en) * 1995-07-26 2008-02-05 Universite De Montreal Elisa serodiagnosis of pig pleuropneumonia serotypes 5a and 5b
ATE345501T1 (de) 1997-04-08 2006-12-15 Univ Montreal Elisa-serodiagnose von schweinepleuropneumonie des serotyps 2
JP3810035B2 (ja) 1997-09-08 2006-08-16 日本精機株式会社 易開封性包装袋およびその製造装置
US6514687B1 (en) * 1998-12-14 2003-02-04 Vertex Pharmaceuticals (San Diego), Llc Optical molecular sensors for cytochrome P450 activity
US6420130B1 (en) * 1998-12-14 2002-07-16 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
DK1140888T3 (da) * 1998-12-14 2003-08-25 Vertex Pharma San Diego Llc Optiske molekylære sensorer for cytochrom P450-aktivitet
US6143492A (en) * 1998-12-14 2000-11-07 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
GB9902068D0 (en) * 1999-01-29 1999-03-24 Smithkline Beecham Plc Compounds
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US6972339B2 (en) 2001-09-07 2005-12-06 Epoch Biosciences, Inc. Compounds and methods for fluorescent labeling
US8569516B2 (en) * 2001-09-07 2013-10-29 Elitech Holding B.V. Compounds and methods for fluorescent labeling
CA2498320A1 (en) * 2002-09-20 2004-04-01 Integrated Dna Technologies, Inc. Anthraquinone quencher dyes, their methods of preparation and use
US7541454B2 (en) * 2003-10-24 2009-06-02 Epoch Biosciences, Inc. Compounds and methods for fluorescent labeling
WO2005042504A1 (en) 2003-10-31 2005-05-12 Molecular Probes, Inc. Fluorinated resorufin compounds and their application in detecting hydrogen peroxide
US7439341B2 (en) 2003-11-14 2008-10-21 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
US7671218B2 (en) 2004-08-13 2010-03-02 Elitech Holdings B.V. Phosphonate fluorescent dyes and conjugates
JP2008545659A (ja) 2005-05-20 2008-12-18 インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド オリゴヌクレオチドを標識する化合物及び方法
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
JP5886828B2 (ja) 2010-03-26 2016-03-16 インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド 核酸のハイブリダイゼーションを強化する方法
US8735575B2 (en) 2010-07-30 2014-05-27 Washington University Phenoxazine derivatives and methods of use thereof
AU2011299233B2 (en) 2010-09-07 2016-09-15 Integrated Dna Technologies, Inc. Modifications for antisense compounds
JP6196968B2 (ja) 2011-05-24 2017-09-13 エリテックグループ・ベスローテン・フェンノートシャップＥｌｉｔｅｃｈｇｒｏｕｐ Ｂ．Ｖ． メチシリン耐性黄色ブドウ球菌の検出
WO2013035703A1 (ja) * 2011-09-09 2013-03-14 コニカミノルタエムジー株式会社 生体物質検出方法
US9642858B2 (en) 2012-10-30 2017-05-09 University of Pittsburgh—of the Commonwealth System of Higher Education Use of resazurin, or analogs thereof, for antibacterial therapy
EP2971106B1 (en) 2013-03-11 2020-02-26 ELITechGroup, Inc. Methods for true isothermal strand displacement amplification
ES2654631T3 (es) 2013-05-13 2018-02-14 Elitechgroup B.V. PCR digital en gotas con sondas cortas de ranura menor
EP3230467A1 (en) 2014-12-12 2017-10-18 ELITechGroup B.V. Methods and compositions for detecting antibiotic resistant bacteria
JP2017538418A (ja) 2014-12-12 2017-12-28 エリテックグループ・ベスローテン・フェンノートシャップＥｌｉｔｅｃｈｇｒｏｕｐ Ｂ．Ｖ． 抗生物質耐性細菌を検出する方法および組成物
WO2021080629A1 (en) 2019-10-23 2021-04-29 Elitechgroup, Inc. Methods for true isothermal strand displacement amplification
EP3932995A1 (en) 2020-07-04 2022-01-05 Emulseo SAS Novel fluorescent substrates and uses thereof in microfluidics

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB807687A (en) * 1955-10-10 1959-01-21 Bayer Ag Phenoxazone-dicarboxylic acid derivatives
US4141688A (en) * 1977-08-11 1979-02-27 Miles Laboratories, Inc. Composition, device and method for determining reducing agents
IT1140209B (it) * 1981-09-25 1986-09-24 Anic Spa Reagenti per immunoluorescenza e metodo per la loro preparazione
US4667032A (en) * 1983-01-21 1987-05-19 Merck Frosst Canada, Inc. Phenothiazone derivatives and analogs
US4859667A (en) * 1983-01-21 1989-08-22 Merck Frosst Canada, Inc. Pharmaceutical compositions of phenothiazone derivatives and analogs
US4714763A (en) * 1985-07-11 1987-12-22 Viomedics Inc. Novel oxazine-ureas and thiazine urea chromophors as fluorescent labels
DE3526566A1 (de) * 1985-07-25 1987-02-05 Boehringer Mannheim Gmbh N-acyl-dihydroresorufin-derivate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung von wasserstoffperoxid, peroxidatisch wirkender verbindungen oder peroxidase
DE3526565A1 (de) * 1985-07-25 1987-02-05 Boehringer Mannheim Gmbh Resorufin-derivate, verfahren zu deren herstellung sowie deren verwendung in fluoreszenzimmunoassays
DE3644401A1 (de) * 1986-12-24 1988-07-07 Boehringer Mannheim Gmbh Neue hydrolase-substrate
US5242805A (en) * 1991-08-23 1993-09-07 Molecular Probes, Inc. Long wavelength lipophilic fluorogenic glycosidase substrates

Also Published As

Publication number Publication date
YU130286A (en) 1987-12-31
US5304645A (en) 1994-04-19
CA1338320C (en) 1996-05-07
KR870001184A (ko) 1987-03-12
DE3673715D1 (de) 1990-10-04
JPS62174066A (ja) 1987-07-30
CS273617B2 (en) 1991-03-12
EP0209875B1 (de) 1990-08-29
DE3526565A1 (de) 1987-02-05
JPS62174067A (ja) 1987-07-30
ATE55998T1 (de) 1990-09-15
YU45348B (en) 1992-05-28
JPS6236368A (ja) 1987-02-17
US4954630A (en) 1990-09-04
SU1621811A3 (ru) 1991-01-15
EP0209875A1 (de) 1987-01-28
CS549286A2 (en) 1990-08-14

Similar Documents

Publication Publication Date Title
ES2002110A6 (es) Procedimiento para la preparacion de derivados de resorufina.
PT83202B (pt) Processo para a preparacao de compostos triciclicos aromaticos e de composicoes farmaceuticas que os contem
ES487537A0 (es) Un procedimiento para la preparacion de nuevos derivados de quinazolina.
CO4910132A1 (es) Agonistas adrenergicos selectivos de beta 3
ES2074205T3 (es) Compuestos heterociclicos condensados, su produccion y uso.
ES451997A1 (es) Procedimiento para preparar colorantes triazinicos.
DK0567622T3 (da) Hidtil ukendte pentacykliske forbindelser og anvendelse heraf som absorptions- eller fluorescensfarvestoffer
ES391026A1 (es) Procedimiento para la obtencion de benzonaftiridina.
GB1526353A (en) Solvent for dyes used in pressure-sensitive copying paper
ES423824A1 (es) Procedimiento para la obtencion de compuestos azoicos que contienen como minimo un grupo ciano en la posicion orto conrelacion al puente azoico.
GB1217714A (en) New water insoluble azo dyes of the benzisothiazole series
ES2075004T3 (es) Derivados de pirimidina, procedimientos para su produccion y composiciones herbicidas que los contienen.
KR910006423A (ko) 아닐린에 근거하는 유응성 아조염료
KR880009959A (ko) 방향족 아민 유도체
AR002072A1 (es) Proceso para la preparacion de derivados de pirrolidin-2-ona utiles como intermediarios en la sintesis de herbicidas.
ES455470A1 (es) Procedimiento para la preparacion compuesto de indolinospi- ropirano.
GB1434743A (en) Perinone dyestuffs and process for preparing them
FR2372873A1 (fr) Colorants azoiques reactifs
ES8106324A1 (es) Procedimiento para preparar colorantes monoazoicos dispersos
ES455701A1 (es) Procedimiento para preparar derivados de tieno 13,2-c pridi-na.
ES2049608B1 (es) Mezcla de complejos de hierro de diazocompuestos metalizables de utilidad como colorantes para el teñido de cuero.
ES450180A1 (es) Procedimiento para preparar colorantes monoazoicos disper- sos.
ES2070961T3 (es) Oxadiazolil-fenoxialquilisoxazoles y su uso como agentes antiviricos.
ES450184A1 (es) Procedimiento para preparar colorantes monoazoicos disper- sos.
ES450181A1 (es) Procedimiento para preparar colorantes monoazoicos disper- sos.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100528