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ES2001000A4 - Derivados de nucleosidos y su utilizacion para la sintesis de oligonucleosidos - Google Patents

Derivados de nucleosidos y su utilizacion para la sintesis de oligonucleosidos

Info

Publication number
ES2001000A4
ES2001000A4 ES87400739T ES87400739T ES2001000A4 ES 2001000 A4 ES2001000 A4 ES 2001000A4 ES 87400739 T ES87400739 T ES 87400739T ES 87400739 T ES87400739 T ES 87400739T ES 2001000 A4 ES2001000 A4 ES 2001000A4
Authority
ES
Spain
Prior art keywords
radical
synthesis
hydrogen atom
derivatives
nucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES87400739T
Other languages
English (en)
Spanish (es)
Inventor
Robert Teoule
Didier Molko
Jean-Claude Schulhof
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Publication of ES2001000A4 publication Critical patent/ES2001000A4/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
ES87400739T 1986-04-08 1987-04-03 Derivados de nucleosidos y su utilizacion para la sintesis de oligonucleosidos Pending ES2001000A4 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8604990A FR2596761B1 (fr) 1986-04-08 1986-04-08 Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides

Publications (1)

Publication Number Publication Date
ES2001000A4 true ES2001000A4 (es) 1988-04-16

Family

ID=9334007

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87400739T Pending ES2001000A4 (es) 1986-04-08 1987-04-03 Derivados de nucleosidos y su utilizacion para la sintesis de oligonucleosidos

Country Status (8)

Country Link
US (1) US4980460A (fr)
EP (2) EP0438203B1 (fr)
JP (2) JPH0631305B2 (fr)
AT (1) ATE67768T1 (fr)
DE (3) DE241363T1 (fr)
ES (1) ES2001000A4 (fr)
FR (1) FR2596761B1 (fr)
GR (1) GR880300040T1 (fr)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204456A (en) * 1986-04-08 1993-04-20 Commissariat A L'energie Atomique Derivatives of nucleosides and their use for the synthesis of oligonucleotides
FR2621591B1 (fr) * 1987-10-08 1990-01-12 Commissariat Energie Atomique Derives de nucleosides, notamment de desoxy-2' cytidine et leur utilisation pour la synthese d'oligonucleotides
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5262530A (en) * 1988-12-21 1993-11-16 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5047524A (en) * 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
GB9009980D0 (en) * 1990-05-03 1990-06-27 Amersham Int Plc Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
US5616700A (en) * 1992-04-24 1997-04-01 Beckman Instruments, Inc. Processes for synthesizing nucleotides and modified nucleotides using N.sub.
US5428148A (en) * 1992-04-24 1995-06-27 Beckman Instruments, Inc. N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
US5348868A (en) * 1992-04-24 1994-09-20 Beckman Instruments, Inc. Methods and reagents for cleaving and deprotecting oligonucleotides
ES2100051T3 (es) * 1993-01-08 1997-06-01 Hybridon Inc Sintesis de bloques dimeros y su uso en el ensamblaje de oligonucleotidos.
US6087491A (en) 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
US5623068A (en) * 1994-03-07 1997-04-22 Beckman Instruments, Inc. Synthesis of DNA using substituted phenylacetyl-protected nucleotides
DE4418691A1 (de) * 1994-05-28 1996-02-22 Boehringer Mannheim Gmbh 3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
US5763594A (en) * 1994-09-02 1998-06-09 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US5872244A (en) * 1994-09-02 1999-02-16 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US6232465B1 (en) 1994-09-02 2001-05-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5808045A (en) * 1994-09-02 1998-09-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5990300A (en) * 1994-09-02 1999-11-23 Andrew C. Hiatt Enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US6214987B1 (en) 1994-09-02 2001-04-10 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
JP4293634B2 (ja) 1995-06-07 2009-07-08 ソレクサ・インコーポレイテッド 分類および同定のためのオリゴヌクレオチドタグ
JP2000500740A (ja) 1995-10-19 2000-01-25 プロリゴ・エルエルシー オリゴヌクレオチドの溶液相合成方法
AU2542097A (en) * 1996-03-26 1997-10-17 Lynx Therapeutics, Inc. Oligonucleotide treatments and compositions for human melanoma
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US6326479B1 (en) 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6153411A (en) * 1998-10-30 2000-11-28 American Water Works Company, Inc. Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
US6184347B1 (en) 1998-11-19 2001-02-06 Agilent Technologies Inc. Minimization of blooming in high-density arrays by using reactive wash reagents
EP1163251A1 (fr) 1999-03-24 2001-12-19 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES N-acylphosphoramidites et leur utilisation dans la synthese d'oligonucleotides
US6221635B1 (en) 1999-05-06 2001-04-24 The Wistar Institute Methods for solid-phase amplification of DNA template (SPADT) using multiarrays
US20070059752A1 (en) * 1999-06-09 2007-03-15 Biosearch Technologies, Inc. Fluorescence energy transfer probes with stabilized conformations
US7255999B2 (en) 2001-05-21 2007-08-14 Monogram Biosciences, Inc. Methods and compositions for analyzing proteins
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US6936702B2 (en) * 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
JP2004516810A (ja) 2000-06-07 2004-06-10 リ−コール インコーポレーティッド 電荷スイッチヌクレオチド
EP1176151B1 (fr) 2000-07-28 2014-08-20 Agilent Technologies, Inc. Synthèse des polynucléotides utilisant la chimie combinée d'oxidation et de protection
ES2327316T3 (es) 2000-09-26 2009-10-28 Boston Probes, Inc. Sondas, conjuntos de sondas, metodos y kits que se refieren a la deteccion, identificacion y/o enumeracion de bacterias.
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
US7118907B2 (en) * 2001-06-06 2006-10-10 Li-Cor, Inc. Single molecule detection systems and methods
WO2003003014A1 (fr) * 2001-06-29 2003-01-09 Veri-Q, Inc. Procedes et compositions pour determiner la purete d'acides nucleiques synthetises par voie chimique et les purifier
US7355037B2 (en) * 2001-12-03 2008-04-08 The United States Of America As Represented By The Department Of Health And Human Services Thermolabile hydroxyl protecting groups and methods of use
US7255874B1 (en) 2001-12-21 2007-08-14 Closure Medical Corporation Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
GB0200526D0 (en) * 2002-01-11 2002-02-27 Science And Technology The Methods
US20060246434A1 (en) * 2002-03-15 2006-11-02 Erlander Mark G Nucleic acid amplification
AU2003249681A1 (en) * 2002-05-31 2003-12-19 Diversa Corporation Multiplexed systems for nucleic acid sequencing
CA2495895A1 (fr) * 2002-09-08 2004-03-18 Applera Corporation Procedes, compositions et banques se rapportant a la synthese de dimere et d'oligomere d'anp
US7745116B2 (en) * 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
US7417139B2 (en) 2003-08-30 2008-08-26 Agilent Technologies, Inc. Method for polynucleotide synthesis
US7193077B2 (en) 2003-08-30 2007-03-20 Agilent Technologies, Inc. Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis
US7385050B2 (en) 2003-08-30 2008-06-10 Agilent Technologies, Inc. Cleavable linker for polynucleotide synthesis
US7427679B2 (en) * 2003-08-30 2008-09-23 Agilent Technologies, Inc. Precursors for two-step polynucleotide synthesis
US9809824B2 (en) * 2004-12-13 2017-11-07 The United States Of America, Represented By The Secretary, Department Of Health And Human Services CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
US7608433B2 (en) 2005-02-09 2009-10-27 Idexx Laboratories Method of detection of classical swine fever
JP2009501024A (ja) * 2005-07-12 2009-01-15 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 癌の診断及び治療における遺伝的及びエピジェネティックな変化
WO2007047408A2 (fr) * 2005-10-12 2007-04-26 Pathologica, Llc. Application de signature promac
WO2010090857A2 (fr) 2009-01-21 2010-08-12 Vertex Pharmaceuticals Incorporated Procédés d'amplification d'acides nucléiques du virus de l'hépatite c
AR084358A1 (es) 2010-12-27 2013-05-08 Lilly Co Eli Composiciones y metodos para identificar y diferenciar componentes virales de vacunas multivalentes de la “fiebre de embarque” (complejo de enfermedad respiratoria bovina (brdc))
CA2822825C (fr) 2010-12-27 2016-02-09 Eli Lilly And Company Compositions vaccinales contre le virus de la diarrhee virale bovine de type 1b (bvdv-1b), et methodes associees
AP2013007005A0 (en) 2010-12-30 2013-07-31 Dow Agrosciences Llc Nucleic acid molecules that target the RHO1 small GTP-binding protein and confer resistance to coleopteran pests
MX353321B (es) 2010-12-30 2018-01-05 Dow Agrosciences Llc Moleculas de acido nucleico dirigidas a la subunidad de atpasa c vacuolar y que confieren resistencia a las plagas de coleopteros.
UY33851A (es) 2010-12-30 2012-07-31 Dow Agrosciences Llc Moléculas de ácido nucleico que confieren resistencia a las plagas de coleópteros
UY33853A (es) 2010-12-30 2012-07-31 Dow Agrosciences Llc ?moléculas de ácido nucleico que se dirigen a la subunidad h de la atpasa vacuolar y confieren resistencia a plagas de coleópteros?.
EP2844775B1 (fr) 2012-05-02 2018-07-18 Ibis Biosciences, Inc. Séquençage d'adn
EP2844772B1 (fr) 2012-05-02 2018-07-11 Ibis Biosciences, Inc. Séquençage d'adn
WO2013173844A1 (fr) 2012-05-18 2013-11-21 Pacific Biosciences Of California, Inc. Colorants hétéroarylcyanines
WO2014072832A2 (fr) 2012-10-18 2014-05-15 Oslo Universitetstssykehus Hf Biomarqueurs pour le cancer du col de l'utérus
ES2685710T3 (es) 2012-10-18 2018-10-10 Idexx Laboratories, Inc. Kits que comprenden controles para amplificación de ácido nucleico
ES2959628T3 (es) 2013-12-20 2024-02-27 Fraunhofer Ges Forschung Moléculas de ácido nucleico RNAPII-140 que confieren resistencia a plagas de coleópteros
BR102014031844A2 (pt) 2013-12-20 2015-10-06 Dow Agrosciences Llc ras oposto (rop) e moléculas de ácido nucleico relacionadas que conferem resistência a pragas de coleópteros e hemípteros
JP2017514492A (ja) 2014-05-07 2017-06-08 ダウ アグロサイエンシィズ エルエルシー 鞘翅目害虫に対する抵抗性を付与するｄｒｅ４核酸分子
US10093967B2 (en) 2014-08-12 2018-10-09 The Regents Of The University Of Michigan Detection of nucleic acids
US20160194658A1 (en) 2014-12-22 2016-07-07 Dow Agrosciences Llc Nucampholin nucleic acid molecules to control coleopteran insect pests
US20160264991A1 (en) 2015-03-13 2016-09-15 Dow Agrosciences Llc Rna polymerase i1 nucleic acid molecules to control insect pests
BR102016012010A2 (pt) 2015-05-29 2020-03-24 Dow Agrosciences Llc Molécula de ácido nucleico, de ácido ribonucleico (rna) e de ácido ribonucleico de filamento duplo (dsrna), usos de célula, planta e semente, produto primário, bem como métodos para controlar uma população de pragas coleópteras e/ou hemípteras, para melhorar o rendimento de uma cultura, e para produzir uma célula vegetal transgênica e uma planta transgênica
GB201511470D0 (en) 2015-06-30 2015-08-12 Cellcall Kft HPV detection method
WO2018089237A1 (fr) 2016-11-10 2018-05-17 Dow Agrosciences Llc Molécules d'acide nucléique de cytochrome b (cytb) qui régulent des pathogènes
EP3342780A1 (fr) 2016-12-30 2018-07-04 Dow AgroSciences LLC Molécules d'acides nucléiques prp8 (prétraitement de l'arnm du facteur 8) pour lutter contre les insectes nuisibles
US12460249B2 (en) 2017-03-08 2025-11-04 The Regents Of The University Of Michigan Protein analyte detection by analizing time-dependent signals from transient binding events of labeled low-affinity probes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
AU542967B2 (en) * 1980-02-29 1985-03-28 University Patents Inc. Preparation of oligonucleotides
EP0090789A1 (fr) * 1982-03-26 1983-10-05 Monsanto Company Synthèse chimique de DNA
DE3650371T2 (de) * 1985-03-28 1996-03-07 Chiron Corp 0,0'-Dicyanoethyl-phosphoramidite, Verfahren zu deren Herstellung und ihre Verwendung in Phosphorylierungsreaktionen.
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates

Also Published As

Publication number Publication date
EP0438203B1 (fr) 1996-11-06
ATE67768T1 (de) 1991-10-15
JPH0694475B2 (ja) 1994-11-24
EP0241363A1 (fr) 1987-10-14
EP0438203A2 (fr) 1991-07-24
DE3773245D1 (de) 1991-10-31
GR880300040T1 (en) 1988-10-18
EP0438203A3 (en) 1991-09-25
JPH0631305B2 (ja) 1994-04-27
DE3751947T2 (de) 1997-05-07
EP0241363B1 (fr) 1991-09-25
FR2596761B1 (fr) 1988-05-20
JPH06199888A (ja) 1994-07-19
DE241363T1 (de) 1988-06-30
US4980460A (en) 1990-12-25
JPS62294692A (ja) 1987-12-22
DE3751947D1 (de) 1996-12-12
FR2596761A1 (fr) 1987-10-09

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