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ES2084560A1 - Process for preparing indole derivatives - Google Patents

Process for preparing indole derivatives

Info

Publication number
ES2084560A1
ES2084560A1 ES09400481A ES9400481A ES2084560A1 ES 2084560 A1 ES2084560 A1 ES 2084560A1 ES 09400481 A ES09400481 A ES 09400481A ES 9400481 A ES9400481 A ES 9400481A ES 2084560 A1 ES2084560 A1 ES 2084560A1
Authority
ES
Spain
Prior art keywords
image
indole derivatives
alkyl group
preparing indole
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09400481A
Other languages
Spanish (es)
Other versions
ES2084560B1 (en
Inventor
Forner M Dolores Fernandez
Duran Carles Puig
Crespo Maria Isabel Crespo
Mauri Jacinto Moragues
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Laboratorios Almirall SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Almirall SA filed Critical Laboratorios Almirall SA
Priority to ES9400481A priority Critical patent/ES2084560B1/en
Priority to BR9500821A priority patent/BR9500821A/en
Priority to FI951047A priority patent/FI116837B/en
Priority to CO95008919A priority patent/CO4340738A1/en
Priority to EG17595A priority patent/EG20611A/en
Priority to UY23929A priority patent/UY23929A1/en
Publication of ES2084560A1 publication Critical patent/ES2084560A1/en
Application granted granted Critical
Publication of ES2084560B1 publication Critical patent/ES2084560B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Process for preparing indole derivatives of formula (I): < IMAGE > where "Z" represents a ring selected from: < IMAGE > (II) in which n is 4, 5 or 6 < IMAGE > (III) < IMAGE > (IV) where R1 is hydrogen or an alkyl group and R2 is an alkyl, methoxy, benzyl or R3NHCO group, where R3 is an alkyl group, and < IMAGE > (V) where R4 is an alkyl group, and pharmaceutically acceptable salts of the same which comprises methylating an aminoethyl indole of formula (IX): < IMAGE > where "Z" is as defined above, including formaldehyde and a boron hydride complex.
ES9400481A 1994-03-09 1994-03-09 EL INDOL DERIVATIVES PREPARATION PROCEDURE. Expired - Fee Related ES2084560B1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES9400481A ES2084560B1 (en) 1994-03-09 1994-03-09 EL INDOL DERIVATIVES PREPARATION PROCEDURE.
BR9500821A BR9500821A (en) 1994-03-09 1995-03-06 Process for the preparation of an indole derivative
FI951047A FI116837B (en) 1994-03-09 1995-03-07 Process for the preparation of indole derivatives
CO95008919A CO4340738A1 (en) 1994-03-09 1995-03-07 PROCEDURE FOR THE PREPARATION OF INDOL DERIVATIVES
EG17595A EG20611A (en) 1994-03-09 1995-03-08 Process for the production of indole derivatives
UY23929A UY23929A1 (en) 1994-03-09 1995-03-09 PROCEDURE FOR THE PREPARATION OF INDEOL DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9400481A ES2084560B1 (en) 1994-03-09 1994-03-09 EL INDOL DERIVATIVES PREPARATION PROCEDURE.

Publications (2)

Publication Number Publication Date
ES2084560A1 true ES2084560A1 (en) 1996-05-01
ES2084560B1 ES2084560B1 (en) 1997-01-16

Family

ID=8285486

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9400481A Expired - Fee Related ES2084560B1 (en) 1994-03-09 1994-03-09 EL INDOL DERIVATIVES PREPARATION PROCEDURE.

Country Status (6)

Country Link
BR (1) BR9500821A (en)
CO (1) CO4340738A1 (en)
EG (1) EG20611A (en)
ES (1) ES2084560B1 (en)
FI (1) FI116837B (en)
UY (1) UY23929A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013098A1 (en) * 2005-07-25 2007-02-01 Matrix Laboratories Limited A process for the preparation of almotriptan

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2774605A1 (en) 2013-02-06 2014-09-10 Galenicum Health S.L. Pharmaceutical composition comprising almotriptan malate having uniform drug distribution and potency
CN106478484B (en) * 2016-08-31 2017-11-10 重庆华森制药股份有限公司 A kind of method for preparing almotriptan key intermediate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8402268A1 (en) * 1980-08-12 1984-01-16 Glaxo Group Ltd Indole-5-acetamides for treatment of migraine
EP0147107A1 (en) * 1983-12-06 1985-07-03 Glaxo Group Limited Indole derivates
ES8801900A1 (en) * 1984-08-01 1988-03-01 Glaxo Group Ltd Indole derivative
ES2033577B1 (en) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 PROCEDURE FOR OBTAINING 2-CARBOXY-3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE AND ITS LOWER ALKYL ESTERS.
ES2033578B1 (en) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 PROCEDURE FOR OBTAINING 3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8402268A1 (en) * 1980-08-12 1984-01-16 Glaxo Group Ltd Indole-5-acetamides for treatment of migraine
ES8500903A1 (en) * 1980-08-12 1984-11-01 Glaxo Group Ltd A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF THE INDOL.
EP0147107A1 (en) * 1983-12-06 1985-07-03 Glaxo Group Limited Indole derivates
ES8801900A1 (en) * 1984-08-01 1988-03-01 Glaxo Group Ltd Indole derivative
ES2033577B1 (en) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 PROCEDURE FOR OBTAINING 2-CARBOXY-3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE AND ITS LOWER ALKYL ESTERS.
ES2033578B1 (en) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 PROCEDURE FOR OBTAINING 3- (2- (DIMETHYLAMINE) ETHYL) -N-METHYL-1H-INDOL-5-METHANOSULFONAMIDE.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013098A1 (en) * 2005-07-25 2007-02-01 Matrix Laboratories Limited A process for the preparation of almotriptan
US7943784B2 (en) * 2005-07-25 2011-05-17 Matrix Laboratories Limited Process for the preparation of almotriptan

Also Published As

Publication number Publication date
UY23929A1 (en) 1995-03-21
FI116837B (en) 2006-03-15
BR9500821A (en) 1995-11-21
FI951047A7 (en) 1995-09-10
EG20611A (en) 1999-09-30
ES2084560B1 (en) 1997-01-16
CO4340738A1 (en) 1996-07-30
FI951047A0 (en) 1995-03-07

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Owner name: ALMIRALL S.A.

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