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ES2084161T3 - Adhesivos de poliisobutileno para dispositivos transdermicos. - Google Patents

Adhesivos de poliisobutileno para dispositivos transdermicos.

Info

Publication number
ES2084161T3
ES2084161T3 ES91908912T ES91908912T ES2084161T3 ES 2084161 T3 ES2084161 T3 ES 2084161T3 ES 91908912 T ES91908912 T ES 91908912T ES 91908912 T ES91908912 T ES 91908912T ES 2084161 T3 ES2084161 T3 ES 2084161T3
Authority
ES
Spain
Prior art keywords
transdermic
devices
polyisbutylene
adhesives
gdp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91908912T
Other languages
English (en)
Inventor
Karly S Wang
James L Osborne
James A Hunt
Melinda K Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24027514&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2084161(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ES2084161T3 publication Critical patent/ES2084161T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A61L15/585—Mixtures of macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTA UN ADHESIVO, UTIL PARA DISPOSITIVOS DE LIBERACION TRANSDERMICA, QUE COMPRENDE UNA MEZCLA DE POLIETILENO DE ALTO Y BAJO PESO MOLECULAR QUE TIENE UNA RELACION HMW PIB: LMW PIB EN LA BANDA DE 5-40:95-60 QUE ESTA SUBSTANCIALMENTE LIBRE DE PLASTIFICADORES Y DE ESPESADORES. EL ADHESIVO ENCUENTRA UN USO PARTICULAR COMO COMPONENTE DE UN DISPOSITIVO DE LIBERACION TRANSDERMICA PARA LIBERAR AGENTES ACEITOSOS NO POLARES TALES COMO NICOTINA, BENZOTRIPENO, SECOVERINA, DEXSECOVERINA, Y ARECOLINA.
ES91908912T 1990-04-16 1991-04-12 Adhesivos de poliisobutileno para dispositivos transdermicos. Expired - Lifetime ES2084161T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/509,644 US5508038A (en) 1990-04-16 1990-04-16 Polyisobutylene adhesives for transdermal devices

Publications (1)

Publication Number Publication Date
ES2084161T3 true ES2084161T3 (es) 1996-05-01

Family

ID=24027514

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91908912T Expired - Lifetime ES2084161T3 (es) 1990-04-16 1991-04-12 Adhesivos de poliisobutileno para dispositivos transdermicos.

Country Status (18)

Country Link
US (1) US5508038A (es)
EP (1) EP0525105B1 (es)
JP (1) JP3035346B2 (es)
KR (1) KR0150228B1 (es)
AT (1) ATE134512T1 (es)
AU (1) AU630817B2 (es)
CA (1) CA2040352A1 (es)
DE (1) DE69117505T2 (es)
DK (1) DK0525105T3 (es)
ES (1) ES2084161T3 (es)
FI (1) FI112171B (es)
GR (1) GR3019157T3 (es)
IE (1) IE74862B1 (es)
NO (1) NO300086B1 (es)
NZ (1) NZ237810A (es)
PT (1) PT97357B (es)
WO (1) WO1991016085A1 (es)
ZA (1) ZA912753B (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251469B (it) * 1991-07-15 1995-05-15 Zambon Spa Sistema terapeutico transdermale per la somministrazione di farmaci ad attivita' broncodilatante.
CA2166869A1 (en) * 1993-07-09 1995-01-19 Ooi Wong Method and device for providing nicotine replacement therapy transdermally/transbuccally
GB2281036A (en) * 1993-08-02 1995-02-22 Agri Tech Topical compositions containing polybutenes
DK0760238T3 (da) * 1994-05-18 2002-07-22 Hisamitsu Pharmaceutical Co Præparat, der kan indgives perkutant, til behandling af vandladningslidelse
AU4657896A (en) * 1995-01-19 1996-08-07 Cygnus, Inc. Polyisobutylene adhesives containing high TG tackifier for transdermal devices
ES2190472T5 (es) * 1995-06-07 2012-03-09 Ortho-Mcneil Pharmaceutical, Inc. Parche transdérmico para la administración de 17-deacetil norgestimato, en combinación con un estrógeno.
JP3545532B2 (ja) * 1996-05-08 2004-07-21 鐘淵化学工業株式会社 複合ゴム粒子および複合ゴム系グラフト共重合体粒子
US6011116A (en) * 1996-05-08 2000-01-04 Kaneka Corporation Thermoplastic resin composition
US6007837A (en) * 1996-07-03 1999-12-28 Alza Corporation Drug delivery devices and process of manufacture
US6174545B1 (en) 1997-07-01 2001-01-16 Alza Corporation Drug delivery devices and process of manufacture
US5948433A (en) * 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
US6605751B1 (en) * 1997-11-14 2003-08-12 Acrymed Silver-containing compositions, devices and methods for making
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
AU774594B2 (en) 1998-12-18 2004-07-01 Alza Corporation Transparent transdermal nicotine delivery devices
AU2742401A (en) * 1999-12-30 2001-07-16 Acrymed Methods and compositions for improved delivery devices
DE10003767A1 (de) 2000-01-28 2001-10-04 Beiersdorf Ag Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung nichtsteroidaler Antirheumatika
DE10056009A1 (de) * 2000-11-11 2002-05-16 Beiersdorf Ag Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung hyperämisierender Wirkstoffe
CN1678277B (zh) 2002-07-29 2010-05-05 艾克里麦德公司 治疗皮肤病的方法和组合物
TWI296531B (en) 2002-10-18 2008-05-11 Hisamitsu Pharmaceutical Co Transdermal adhesive preparations for topical administration of fentanyl
US8361553B2 (en) 2004-07-30 2013-01-29 Kimberly-Clark Worldwide, Inc. Methods and compositions for metal nanoparticle treated surfaces
NZ552928A (en) 2004-07-30 2011-05-27 Acrymed Inc Antimicrobial silver compositions
US10251392B2 (en) * 2004-07-30 2019-04-09 Avent, Inc. Antimicrobial devices and compositions
JP4745747B2 (ja) * 2004-08-12 2011-08-10 日東電工株式会社 フェンタニル含有貼付製剤
JP4824963B2 (ja) * 2004-08-12 2011-11-30 日東電工株式会社 貼付材及び貼付製剤
US9289378B2 (en) * 2004-09-20 2016-03-22 Avent, Inc. Antimicrobial amorphous compositions
JP5058531B2 (ja) 2005-09-09 2012-10-24 日東電工株式会社 ビソプロロール含有貼付製剤
WO2007035940A2 (en) * 2005-09-23 2007-03-29 Alza Corporation Transdermal norelgestromin delivery system
EP1948142B1 (en) 2005-09-23 2014-04-09 ALZA Corporation High enhancer-loading polyacrylate formulation for transdermal applications
ES2499067T3 (es) 2005-10-13 2014-09-26 Nitto Denko Corporation Preparación transdérmica de nicotina y método de producción de la misma
EP2015722B1 (en) * 2006-04-28 2016-11-16 Avent, Inc. Antimicrobial site dressings
EP2117521B1 (en) 2006-11-03 2012-06-27 Durect Corporation Transdermal delivery systems comprising bupivacaine
US20080154230A1 (en) * 2006-12-20 2008-06-26 Janardhanan Anand Subramony Anode for electrotransport of cationic drug
US20100041704A1 (en) * 2007-01-12 2010-02-18 Aberg A K Gunnar Dermal compositions of substituted amides and the use thereof as medication for pain and pruritus
WO2008108424A1 (ja) * 2007-03-08 2008-09-12 Nitto Denko Corporation ビソプロロール経皮投与デバイス
WO2008154368A2 (en) 2007-06-08 2008-12-18 University Of Virginia Patent Foundation Topical poloxamer formulations for enhancing microvascular flow: compositions and uses thereof
KR101583680B1 (ko) * 2007-10-15 2016-01-08 알자 코퍼레이션 펜타닐의 1일-1회 교체 경피 투여
MX2011005436A (es) 2008-11-24 2011-11-04 Kimberly Clark Co Constructos laminados antimicrobianos.
KR101738650B1 (ko) * 2009-07-21 2017-05-22 밀란 인크. 폴리이소부틸렌계 경피 패치의 연속 제조 방법
DE102009048973A1 (de) * 2009-10-09 2011-04-14 Beiersdorf Ag Transdermale therapeutische Systeme enthaltend 4-n-Butylresorcin
DE102011100619A1 (de) 2010-05-05 2012-01-05 Amw Gmbh Transdermales therapeutisches System (TTS) mit einem Gehalt an einem Opiod-Analgetikum
WO2012084969A1 (en) 2010-12-22 2012-06-28 Hexal Ag Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition
WO2012105620A1 (ja) * 2011-02-02 2012-08-09 日東電工株式会社 貼付剤および貼付製剤
JP5698018B2 (ja) * 2011-02-02 2015-04-08 日東電工株式会社 貼付剤および貼付製剤
US9072682B2 (en) 2012-12-31 2015-07-07 Mylan Inc. Transdermal dosage form for low-melting point active agent
US20140271923A1 (en) 2013-03-14 2014-09-18 Christopher Brian Reid Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
AU2014281317A1 (en) * 2013-06-20 2016-02-04 Mylan Technologies, Inc. Storage stable transdermal patch of rotigotine
DE102017104026A1 (de) 2017-02-27 2018-08-30 Lts Lohmann Therapie-Systeme Ag Nicotin enthaltendes transparentes transdermales therapeutisches System
US10406114B2 (en) * 2017-06-11 2019-09-10 Masoumeh Nasrollahzadeh Abyazani Antibiotic-loaded transdermal patch
DE102017115701B4 (de) * 2017-07-12 2022-03-03 Lts Lohmann Therapie-Systeme Ag Fampridin-TTS
WO2021226470A1 (en) * 2020-05-08 2021-11-11 WeCool Toys Inc. Modular and customizable toy systems comprising building blocks, removable non-adhesive graphics, and built-in instructions
US20240149185A1 (en) * 2022-11-04 2024-05-09 Charlie-Kao Industry Co., Ltd. Building block assembly

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3252802A (en) * 1964-06-11 1966-05-24 Canadian Patents Dev Method of supplementing the feed of growing swine with nicotine
US3433775A (en) * 1966-01-12 1969-03-18 Exxon Research Engineering Co Process of making butyl rubber whereby a broad molecular weight distribution is obtained under controlled conditions
GB1163339A (en) * 1966-01-25 1969-09-04 Montedison Spa Polyisobutene
US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3734097A (en) * 1969-04-01 1973-05-22 Alza Corp Therapeutic adhesive tape
US3877468A (en) * 1970-07-22 1975-04-15 Leo Ab Chewable tobacco substitute composition
US3731683A (en) * 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US3845217A (en) * 1972-11-16 1974-10-29 Helsingborg L Ab Buffered smoking substitute compositions
US3870794A (en) * 1974-02-20 1975-03-11 Foundation For Behavioral Rese Treatment of certain emotional disorders with nicotine compounds
US4125623A (en) * 1974-04-08 1978-11-14 U.S. Philips Corporation Spasmolytics
NL178686C (nl) * 1974-04-08 1986-05-01 Duphar Int Res Werkwijze ter bereiding of vervaardiging van spasmolytisch werkzame preparaten en werkwijze ter bereiding van n-alkyl-n-gesubstitueerd alkylbeta-fenylethylaminen met spasmolytische werking.
US3923939A (en) * 1974-06-07 1975-12-02 Alza Corp Process for improving release kinetics of a monolithic drug delivery device
US3926188A (en) * 1974-11-14 1975-12-16 Alza Corp Laminated drug dispenser
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4562075A (en) * 1982-05-20 1985-12-31 Nelson Research & Development Co. Penetration enhancers for transdermal drug delivery of systemic agents
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4262003A (en) * 1975-12-08 1981-04-14 Alza Corporation Method and therapeutic system for administering scopolamine transdermally
US4060084A (en) * 1976-09-07 1977-11-29 Alza Corporation Method and therapeutic system for providing chemotherapy transdermally
DE2702604C2 (de) * 1977-01-22 1984-08-30 Basf Ag, 6700 Ludwigshafen Polyisobutene
US4201211A (en) * 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4748181A (en) * 1979-08-28 1988-05-31 Foundation For Behavioral Research Method for treating hypertension with nicotine
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4425337A (en) * 1981-12-30 1984-01-10 Merck & Co., Inc. Adjuvants for rectal delivery of drug
US4440740A (en) * 1982-04-26 1984-04-03 Merck & Co., Inc. α-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption
IE54286B1 (en) * 1983-01-18 1989-08-16 Elan Corp Plc Drug delivery device
DE3344691A1 (de) * 1983-12-10 1985-06-20 Bayer Ag, 5090 Leverkusen Wirkstoffabgasesysteme
DE3347278A1 (de) * 1983-12-28 1985-07-11 Bayer Ag, 5090 Leverkusen Wirkstoffabgabesysteme
DE3586707T2 (de) * 1984-10-05 1993-02-11 Hercon Lab System zur transdermalen applikation eines arzneimittels.
US4573995A (en) * 1984-10-09 1986-03-04 Alza Corporation Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine
DE3438284A1 (de) * 1984-10-16 1985-03-07 Hans-Harald von 2400 Lübeck Tilly Nikotinhaltiges depotpflaster
US4752478A (en) * 1984-12-17 1988-06-21 Merck & Co., Inc. Transdermal system for timolol
DE3685227D1 (de) * 1985-01-04 1992-06-17 Squibb & Sons Inc Wundverband.
US4597961A (en) * 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US4680172A (en) * 1985-03-05 1987-07-14 Ciba-Geigy Corporation Devices and methods for treating memory impairment
US4665069A (en) * 1985-04-02 1987-05-12 Barnett Rosenberg Analgesic composition and method of relieving pain
EP0204968B1 (de) * 1985-05-24 1989-09-27 Beiersdorf Aktiengesellschaft Nitro-Pflaster
DE3518707A1 (de) * 1985-05-24 1986-11-27 Beiersdorf Ag, 2000 Hamburg Nitro-pflaster
US4647580A (en) * 1985-07-18 1987-03-03 Syntex (U.S.A.) Inc. Treatment of Alzheimer's disease
US4715387A (en) * 1985-08-23 1987-12-29 The Regents Of The Univ. Of California Aerosol for use in the reduction of tobacco smoking
WO1987002870A1 (en) * 1985-11-14 1987-05-21 Rosen David I Transdermal application of nicotine
US4797284A (en) * 1986-03-12 1989-01-10 Merck & Co., Inc. Transdermal drug delivery system
DE3786199T2 (de) * 1986-04-03 1993-09-23 Hercon Lab Artikel fuer die verabreichung pharmakologisch aktiver substanzen.
DE3629304A1 (de) * 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung
EP0273004B1 (de) * 1986-11-20 1993-08-11 Ciba-Geigy Ag Benutzer-aktivierte Therapeutische Systeme
US4839174A (en) * 1987-10-05 1989-06-13 Pharmetrix Corporation Novel transdermal nicotine patch
JPH01251619A (ja) * 1988-03-30 1989-10-06 Nec Corp 半導体装置の製造方法
JPH0725669B2 (ja) * 1988-12-23 1995-03-22 日東電工株式会社 経皮投与用医薬製剤

Also Published As

Publication number Publication date
ATE134512T1 (de) 1996-03-15
FI112171B (fi) 2003-11-14
DE69117505T2 (de) 1996-07-11
AU630817B2 (en) 1992-11-05
PT97357A (pt) 1992-01-31
WO1991016085A1 (en) 1991-10-31
DK0525105T3 (da) 1996-06-24
PT97357B (pt) 1998-08-31
US5508038A (en) 1996-04-16
KR0150228B1 (ko) 1998-10-01
EP0525105B1 (en) 1996-02-28
FI924676A0 (fi) 1992-10-15
NO923954D0 (no) 1992-10-12
IE911244A1 (en) 1991-10-23
DE69117505D1 (de) 1996-04-04
FI924676L (fi) 1992-10-15
EP0525105A1 (en) 1993-02-03
NO923954L (no) 1992-12-16
JP3035346B2 (ja) 2000-04-24
IE74862B1 (en) 1997-08-13
GR3019157T3 (en) 1996-05-31
ZA912753B (en) 1992-01-29
NO300086B1 (no) 1997-04-07
JPH05507682A (ja) 1993-11-04
NZ237810A (en) 1992-03-26
CA2040352A1 (en) 1991-10-17
AU7852191A (en) 1991-11-11

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