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ES2074828T3 - Copoliester degradable de 4-hidroxi-prolina y composicion farmaceutica que lo contiene. - Google Patents

Copoliester degradable de 4-hidroxi-prolina y composicion farmaceutica que lo contiene.

Info

Publication number
ES2074828T3
ES2074828T3 ES92307924T ES92307924T ES2074828T3 ES 2074828 T3 ES2074828 T3 ES 2074828T3 ES 92307924 T ES92307924 T ES 92307924T ES 92307924 T ES92307924 T ES 92307924T ES 2074828 T3 ES2074828 T3 ES 2074828T3
Authority
ES
Spain
Prior art keywords
pharmaceutical composition
copoliester
prolin
degradable
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92307924T
Other languages
English (en)
Inventor
Seiji Mochizuki
Kiyoshi Nawata
Yuji Makino
Yoshiki Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of ES2074828T3 publication Critical patent/ES2074828T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6852—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE DESCRIBE UN COPOLIMERO BIODEGRADABLE QUE TIENE UNIDADES CONSTITUYENTES DERIVADAS DE 4 FATICO (ALFA) HIDROXICARBOXILICO, REPRESENTADO POR LAS ESTRUCTURAS (I) Y (II): DONDE X REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ACILO QUE TIENE LA FORMULA RCONO O UN GRUPO ALCOXI CON 1 A 20 ATOMOS DE CARBONO, E Y REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO CON 1 A 8 ATOMOS DE CARBONO, Y N Y M SON INDEPENDIENTEMENTE ENTEROS DE 1 O MAS, M+N ES AL MENOS 10, Y M/(M+N) ES AL MENOS 0,01 Y COMPOSICION FARMACEUTICA QUE LO CONTIENE.
ES92307924T 1991-09-06 1992-09-01 Copoliester degradable de 4-hidroxi-prolina y composicion farmaceutica que lo contiene. Expired - Lifetime ES2074828T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP25429091 1991-09-06

Publications (1)

Publication Number Publication Date
ES2074828T3 true ES2074828T3 (es) 1995-09-16

Family

ID=17262915

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92307924T Expired - Lifetime ES2074828T3 (es) 1991-09-06 1992-09-01 Copoliester degradable de 4-hidroxi-prolina y composicion farmaceutica que lo contiene.

Country Status (7)

Country Link
US (1) US5395916A (es)
EP (1) EP0531091B1 (es)
JP (1) JPH05202177A (es)
AT (1) ATE125278T1 (es)
DE (1) DE69203551T2 (es)
DK (1) DK0531091T3 (es)
ES (1) ES2074828T3 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765177B2 (en) * 1997-09-12 2014-07-01 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US6372880B1 (en) 1997-12-25 2002-04-16 Mitsui Chemicals, Inc. Copolymer and process for preparing the same
WO2001010414A1 (en) * 1999-08-04 2001-02-15 Oakwood Laboratories L.L.C. Slow release microspheres
US7265247B1 (en) 2006-07-28 2007-09-04 Im&T Research, Inc. Substituted phenylsulfur trifluoride and other like fluorinating agents
US8399720B2 (en) * 2007-03-23 2013-03-19 Ube Industries, Ltd. Methods for producing fluorinated phenylsulfur pentafluorides
KR101421921B1 (ko) * 2007-03-23 2014-07-22 우베 인더스트리즈 리미티드 아릴설퍼 펜타플루오라이드의 제조공정
US8030516B2 (en) * 2007-10-19 2011-10-04 Ube Industries, Ltd. Methods for producing perfluoroalkanedi(sulfonyl chloride)
JP2011518765A (ja) * 2007-12-11 2011-06-30 宇部興産株式会社 ジフルオロメチレン−及びトリフルオロメチル−含有化合物を製造するための方法及び組成物
TW201006787A (en) * 2008-03-07 2010-02-16 Im & T Res Inc Fluorination processes with arylsulfur halotetrafluorides
CN102186812A (zh) * 2008-08-18 2011-09-14 宇部兴产株式会社 制备氟烷基芳基亚磺酰基化合物及其氟化的化合物的方法
KR101676054B1 (ko) * 2008-09-22 2016-11-14 우베 고산 가부시키가이샤 폴리(펜타플루오로설파닐)방향족 화합물을 제조하기 위한 공정
US20100174096A1 (en) * 2009-01-05 2010-07-08 Im&T Research, Inc. Methods for Production of Optically Active Fluoropyrrolidine Derivatives
WO2010081014A1 (en) * 2009-01-09 2010-07-15 Im&T Research, Inc. Novel 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
USRE30170E (en) * 1975-04-04 1979-12-18 Sutures, Inc. Hydrolyzable polymers of amino acid and hydroxy acids
US4428939A (en) * 1981-10-16 1984-01-31 Prockop Darwin J Collagen inhibiting compositions and processes for manufacturing and using same
JPS61172813A (ja) * 1985-01-28 1986-08-04 Japan Atom Energy Res Inst ポリ乳酸を担体とする徐放性複合体の製造方法
JPH0720859B2 (ja) * 1985-02-07 1995-03-08 武田薬品工業株式会社 マイクロカプセルの製造法
US4831107A (en) * 1986-07-28 1989-05-16 Semih Erhan Polymer preparation from lysine and a quinone
JPS6341416A (ja) * 1986-08-08 1988-02-22 Takeda Chem Ind Ltd 鎮痛性ペプチド含有マイクロカプセルの製造法
JP2702729B2 (ja) * 1988-02-24 1998-01-26 エーザイ株式会社 徐放性埋込剤
CA2046830C (en) * 1990-07-19 1999-12-14 Patrick P. Deluca Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer

Also Published As

Publication number Publication date
ATE125278T1 (de) 1995-08-15
EP0531091B1 (en) 1995-07-19
DE69203551T2 (de) 1996-01-11
JPH05202177A (ja) 1993-08-10
DE69203551D1 (de) 1995-08-24
US5395916A (en) 1995-03-07
DK0531091T3 (da) 1995-09-11
EP0531091A1 (en) 1993-03-10

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