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ES2054650T3 - Fenilacetonitrilos basicamente substituidos, su obtencion y medicamentos que los contienen. - Google Patents

Fenilacetonitrilos basicamente substituidos, su obtencion y medicamentos que los contienen.

Info

Publication number
ES2054650T3
ES2054650T3 ES87117946T ES87117946T ES2054650T3 ES 2054650 T3 ES2054650 T3 ES 2054650T3 ES 87117946 T ES87117946 T ES 87117946T ES 87117946 T ES87117946 T ES 87117946T ES 2054650 T3 ES2054650 T3 ES 2054650T3
Authority
ES
Spain
Prior art keywords
phenylacetonitrils
obtaining
medicines containing
basically substituted
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87117946T
Other languages
English (en)
Inventor
Werner Dr Seitz
Liliane Dr Unger
Manfred Dr Raschack
Verena Dr Baldinger
Klaus Dr Ruebsamen
Josef Dr Gries
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2054650T3 publication Critical patent/ES2054650T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

SE DESCRIBEN FENILACETONITRILOS SUSTITUIDOS CON BASES DE FORMULA (I) EN LA QUE R1 A R6 Y N TIENEN EL SIGNIFICADO QUE SE INDICA EN LA DESCRIPCION, ASI COMO LA OBTENCION DE ESTOS. ESTOS COMPUESTOS SON APROPIADOS PARA EL TRATAMIENTO DE ENFERMEDADES.
ES87117946T 1986-12-11 1987-12-04 Fenilacetonitrilos basicamente substituidos, su obtencion y medicamentos que los contienen. Expired - Lifetime ES2054650T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863642331 DE3642331A1 (de) 1986-12-11 1986-12-11 Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ES2054650T3 true ES2054650T3 (es) 1994-08-16

Family

ID=6315963

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87117946T Expired - Lifetime ES2054650T3 (es) 1986-12-11 1987-12-04 Fenilacetonitrilos basicamente substituidos, su obtencion y medicamentos que los contienen.

Country Status (9)

Country Link
US (1) US4940780A (es)
EP (1) EP0271013B1 (es)
JP (1) JP2569088B2 (es)
AT (1) ATE90339T1 (es)
AU (1) AU611113B2 (es)
CA (1) CA1337991C (es)
DE (1) DE3642331A1 (es)
ES (1) ES2054650T3 (es)
ZA (1) ZA879280B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1276178C (en) * 1985-10-18 1990-11-13 Chi-Dean Liang Bicyclo-substituted phenylacetonitrile derivatives
CH676845A5 (es) * 1986-11-07 1991-03-15 Oreal
GB8823203D0 (en) * 1988-10-04 1988-11-09 Pfizer Ltd Therapeutic agents
IE64870B1 (en) * 1989-12-21 1995-09-20 Searle & Co Methods of using 2-isopropyl-2-phenylaminovaleronitriles immunosuppressants and vasodilators
CA2032872A1 (en) * 1989-12-21 1991-06-22 Philippe R. Bovy W-amino-.alpha.-phenylalkanonitrile derivatives
US5162569A (en) * 1989-12-21 1992-11-10 G. D. Searle & Co. Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
US5223536A (en) * 1991-07-23 1993-06-29 Fmc Corporation 1,4-diaryl-1-cyclopropyl-4-substituted butanes as insecticides and acaricides
US5393913A (en) * 1993-03-03 1995-02-28 Rhone-Poulenc Inc. N-formylanilines
FR2717473B1 (fr) * 1994-03-16 1996-06-28 Esteve Labor Dr Dérivés de cyclopropylacétonitrile, leur préparation et leur application comme médicaments.
DE19502967A1 (de) * 1995-01-31 1996-08-01 Basf Ag Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen
GB9618835D0 (en) * 1996-09-10 1996-10-23 Chiroscience Ltd Process
US5859279A (en) * 1996-09-10 1999-01-12 Darwin Discovery Limited Compound and process
WO2000055122A1 (en) 1999-03-16 2000-09-21 Eisai Co., Ltd. Nitrile derivatives
WO2003082234A1 (fr) * 2002-03-28 2003-10-09 Shiseido Co., Ltd. Derives de phenylacetonitrile, tonique capillaire et preparations externes pour la peau contenant ces derives

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA916157A (en) * 1972-12-05 Dengel Ferdinand Basically substituted phenylacetonitriles and method for their preparation
FR1449564A (fr) * 1962-04-02 1966-05-06 Knoll Ag Procédé de préparation de phénylacétronitriles substitués par des groupes basiques
NL127712C (es) * 1964-12-21
DE1493904A1 (de) * 1965-07-31 1969-06-19 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
DE1643429A1 (de) * 1967-09-20 1971-01-28 Knoll Ag Basisch substituierte Phenylacetonitrile und Verfahren zu deren Herstellung
GB1202750A (en) * 1967-12-11 1970-08-19 Knoll Ag Substituted phenylacetonitriles
US4003914A (en) * 1973-12-21 1977-01-18 Hoffmann-La Roche Inc. Sulphur containing derivatives
CH611614A5 (en) * 1973-12-21 1979-06-15 Hoffmann La Roche Process for the preparation of heterocyclic compounds
DE2509797C2 (de) * 1975-03-06 1985-07-18 Dr. Karl Thomae Gmbh, 7950 Biberach Phthalimidine, deren physiologisch verträgliche Säureadditionssalze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
AT345806B (de) * 1975-03-06 1978-10-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer substituierter arylalkylamine und deren salze
DE2631222C3 (de) * 1976-07-12 1979-01-04 Knoll Ag, 6700 Ludwigshafen Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
DE3144150A1 (de) * 1981-04-10 1982-12-09 Basf Ag, 6700 Ludwigshafen (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel
DE3138488A1 (de) * 1981-09-28 1983-04-14 Knoll Ag, 6700 Ludwigshafen Verwendung von basisch substituierten phenylacetonritrilen bei der vorbeugenden bekaempfung von krankheiten und mittel dafuer
JPS59304A (ja) * 1982-06-23 1984-01-05 Agency Of Ind Science & Technol 水−アルコ−ル分離膜の製造方法
JPS59146001A (ja) * 1983-02-09 1984-08-21 Seiko Epson Corp 眼鏡レンズ
DE3344755A1 (de) * 1983-12-10 1985-06-20 Basf Ag, 6700 Ludwigshafen 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten
DE3409612A1 (de) * 1984-03-16 1985-09-19 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte isochromane und oxepine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
DE3433383A1 (de) * 1984-09-12 1986-03-20 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phenyl-acetonitril-derivate
US4612329A (en) * 1984-10-17 1986-09-16 Hokuriku Pharmaceutical Co., Ltd. Pharmaceutical alpha-aminoalkyl-alpha-alkylphenylacetonitriles
GB8426738D0 (en) * 1984-10-23 1984-11-28 Scras Pyridine derivatives
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
CA1276178C (en) * 1985-10-18 1990-11-13 Chi-Dean Liang Bicyclo-substituted phenylacetonitrile derivatives
US4593042A (en) * 1985-10-18 1986-06-03 G. D. Searle & Co. Bicyclo-substituted phenylacetonitrile derivatives
DE3603032A1 (de) * 1986-01-31 1987-08-06 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
CA1337991C (en) 1996-01-23
EP0271013A3 (en) 1990-01-24
AU611113B2 (en) 1991-06-06
ATE90339T1 (de) 1993-06-15
AU8240387A (en) 1988-06-16
JP2569088B2 (ja) 1997-01-08
JPS63156763A (ja) 1988-06-29
US4940780A (en) 1990-07-10
DE3642331A1 (de) 1988-06-23
EP0271013A2 (de) 1988-06-15
EP0271013B1 (de) 1993-06-09
ZA879280B (en) 1989-08-30

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