ES1265629U - Cosmetic composition of liposomes containing a quaternized derivative of 18-methyl eicosanoic acid (Machine-translation by Google Translate, not legally binding) - Google Patents
Cosmetic composition of liposomes containing a quaternized derivative of 18-methyl eicosanoic acid (Machine-translation by Google Translate, not legally binding) Download PDFInfo
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- ES1265629U ES1265629U ES202130082U ES202130082U ES1265629U ES 1265629 U ES1265629 U ES 1265629U ES 202130082 U ES202130082 U ES 202130082U ES 202130082 U ES202130082 U ES 202130082U ES 1265629 U ES1265629 U ES 1265629U
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- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 239000002502 liposome Substances 0.000 title claims abstract description 10
- 239000002537 cosmetic Substances 0.000 title claims abstract description 7
- WSRCOZWDQPJAQT-UHFFFAOYSA-N 18-methylicosanoic acid Chemical class CCC(C)CCCCCCCCCCCCCCCCC(O)=O WSRCOZWDQPJAQT-UHFFFAOYSA-N 0.000 title description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 18
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 12
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 6
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 6
- 229930195725 Mannitol Natural products 0.000 claims abstract description 6
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 6
- 229940106189 ceramide Drugs 0.000 claims abstract description 6
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 6
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000594 mannitol Substances 0.000 claims abstract description 6
- 235000010355 mannitol Nutrition 0.000 claims abstract description 6
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 6
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims abstract description 6
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 6
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 6
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 6
- 150000003839 salts Chemical class 0.000 claims abstract description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 6
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 6
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000006185 dispersion Substances 0.000 claims abstract description 3
- ZPFAVCIQZKRBGF-UHFFFAOYSA-N 1,3,2-dioxathiolane 2,2-dioxide Chemical compound O=S1(=O)OCCO1 ZPFAVCIQZKRBGF-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 235000002639 sodium chloride Nutrition 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 2
- KIWBPDUYBMNFTB-UHFFFAOYSA-N Ethyl hydrogen sulfate Chemical compound CCOS(O)(=O)=O KIWBPDUYBMNFTB-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 235000021321 essential mineral Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000003646 hair health Effects 0.000 description 1
- 230000003699 hair surface Effects 0.000 description 1
- 239000008350 hydrogenated phosphatidyl choline Substances 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000008105 phosphatidylcholines Chemical class 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
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- Cosmetics (AREA)
Abstract
Una composición cosmética en forma de una dispersión acuosa y estable de liposomas, caracterizada porque tiene la siguiente composición: a. entre 3,00 y 4,00% en peso de fosfatidilcolina pura, b. entre 0,10 y 1,00% en peso de fosfatidilcoliona hidrogenada, c. entre 5,60 y 8,00% en peso de manitol; d. entre 2,00 y 5,00% en peso de glicerol, e. entre 1,00 y 2,00% en peso de colesterol, f. entre 0,50 y 1,00% en peso de sorbato potásico, g. entre 0,50 y 1,00% en peso de benzoato sódico, h. entre 0,05 y 0,20% en peso de sal de origen marino, i. entre 0,60 y 1,20% en peso de dipropilenglicol, j. entre 0,40 y 0,80% en peso de C10-40 Isoalquilamidopropiletildimonium Etosulfato, k. entre 0,30 y 0,60% en peso de ceramida, l. agua hasta l00,00% en peso, donde dichos % en peso son con respecto al peso total de la composición.A cosmetic composition in the form of a stable, aqueous dispersion of liposomes, characterized in that it has the following composition: a. between 3.00 and 4.00% by weight of pure phosphatidylcholine, b. between 0.10 and 1.00% by weight of hydrogenated phosphatidylcholione, c. between 5.60 and 8.00% by weight of mannitol; d. between 2.00 and 5.00% by weight of glycerol, e. between 1.00 and 2.00% by weight of cholesterol, f. between 0.50 and 1.00% by weight of potassium sorbate, g. between 0.50 and 1.00% by weight of sodium benzoate, h. between 0.05 and 0.20% by weight of salt of marine origin, i. between 0.60 and 1.20% by weight of dipropylene glycol, j. between 0.40 and 0.80% by weight of C10-40 Isoalkylamidopropylethyldimonium Etosulfate, k. between 0.30 and 0.60% by weight of ceramide, l. water up to 100.00% by weight, where said% by weight are relative to the total weight of the composition.
Description
DESCRIPCIÓNDESCRIPTION
Composición cosmética de liposomas que contienen un derivado cuaternizado de ácido 18-metil eicosanoicoCosmetic composition of liposomes containing a quaternized derivative of 18-methyl eicosanoic acid
ANTECEDENTESBACKGROUND
La presente invención pertenece al campo de la cosmética, concretamente al de aplicaciones capilares, y consta de un liposoma que contiene un derivado cuaternizado de ácido 18-metil eicosanoico (18-MEA).The present invention belongs to the field of cosmetics, specifically to that of hair applications, and consists of a liposome containing a quaternized derivative of 18-methyl eicosanoic acid (18-MEA).
DESCRIPCIÓN DE LA INVENCIÓNDESCRIPTION OF THE INVENTION
Los liposomas son vesículas esféricas con una membrana compuesta de una doble capa de fosfolípidos, que constan de partes hidrosolubles y liposolubles. Los liposomas son osmóticamente activos y estables y presentan numerosas ventajas, como su buen poder de solubilización o su capacidad de aumentar la estabilidad de una molécula contenida en ellos debido a la carga eléctrica de su superficie. Además, son biodegradables, biocompatibles y no inmunogénicos y exhiben una buena estabilidad coloidal, química y biológica.Liposomes are spherical vesicles with a membrane composed of a double layer of phospholipids, consisting of water-soluble and fat-soluble parts. Liposomes are osmotically active and stable and have numerous advantages, such as their good solubilization power or their ability to increase the stability of a molecule contained in them due to the electrical charge on their surface. Furthermore, they are biodegradable, biocompatible and non-immunogenic and exhibit good colloidal, chemical and biological stability.
La presente invención se refiere a una composición cosmética que comprende una solución acuosa y estable de liposomas que contienen un derivado cuaternizado de 18-MEA, el lípido principal de la superficie del cabello y que, por tanto, confiere una carga catiónica al liposoma, lo que permite una adhesión al cabello y posterior liberación de los activos encaspulados, mientras brinda protección y ayuda al cabello a recuperar o mantener su aspecto saludable. Dicho derivado cuaternizado de 18-MEA es C10-40 Isoalquilamidopropiletildimonium Etosulfato, también llamado 3-(1-oxo-C10-40-isoalquil)amino-N-etil-N,N-dimetilpropanamino etil sulfato.The present invention relates to a cosmetic composition comprising a stable, aqueous solution of liposomes containing a quaternized derivative of 18-MEA, the main lipid on the hair surface and which, therefore, confers a cationic charge on the liposome, thereby that allows adhesion to the hair and subsequent release of the encapulated assets, while providing protection and helping the hair to regain or maintain its healthy appearance. Said quaternized derivative of 18-MEA is C10-40 Isoalkylamidopropylethyldimonium Ethosulfate, also called 3- (1-oxo-C10-40-isoalkyl) amino-N-ethyl-N, N-dimethylpropanamino ethyl sulfate.
Asimismo, esta composición contiene sal de origen marino, preferiblemente del Mar Muerto de Jordania, la cual contiene minerales esenciales que aportan propiedades de gran interés para el cabello.Also, this composition contains salt of marine origin, preferably from the Dead Sea of Jordan, which contains essential minerals that provide properties of great interest to the hair.
Así, la presente invención se refiere a una composición cosmética para uso capilar, en forma de una dispersión acuosa y estable de liposomas, caracterizada porque contiene el derivado cuaternizado de 18-MEA, C10-40 Isoalquilamidopropiletildimonium Etosulfato en una proporción de entre 0,40 y 0,80 % en peso con respecto al peso total de la composición. Thus, the present invention refers to a cosmetic composition for hair use, in the form of an aqueous and stable dispersion of liposomes, characterized in that it contains the quaternized derivative of 18-MEA, C10-40 Isoalkylamidopropylethyldimonium Etosulfate in a proportion of between 0.40 and 0.80% by weight with respect to the total weight of the composition.
En una realización preferida, el contenido del derivado cuaternizado de 18-MEA es de entre 0,50 y 0,70 % en peso con respecto al peso total de la composición.In a preferred embodiment, the content of the quaternized derivative of 18-MEA is between 0.50 and 0.70% by weight with respect to the total weight of the composition.
En una realización preferida de la invención, la composición comprende:In a preferred embodiment of the invention, the composition comprises:
a. entre 3,00 y 4,00 % en peso de fosfatidilcolina pura,to. between 3.00 and 4.00% by weight of pure phosphatidylcholine,
b. entre 0,10 y 1,00 % en peso de fosfatidilcoliona hidrogenada,b. between 0.10 and 1.00% by weight of hydrogenated phosphatidylcolione,
c. entre 5,60 y 8,00 % en peso de manitol,c. between 5.60 and 8.00% by weight of mannitol,
d. entre 2,00 y 5,00 % en peso de glicerol,d. between 2.00 and 5.00% by weight of glycerol,
e. entre 1,00 y 2,00 % en peso de colesterol,and. between 1.00 and 2.00% by weight of cholesterol,
f. entre 0,50 y 1,00 % en peso de sorbato potásico,F. between 0.50 and 1.00% by weight of potassium sorbate,
g. entre 0,50 y 1,00 % en peso de benzoato sódico,g. between 0.50 and 1.00% by weight of sodium benzoate,
h. entre 0,05 y 0,20 % en peso de sal de origen marino,h. between 0.05 and 0.20% by weight of salt of marine origin,
i. entre 0,60 y 1,20 % en peso de dipropilenglicol,i. between 0.60 and 1.20% by weight of dipropylene glycol,
j. entre 0,40 y 0,80 % en peso de C10-40 Isoalquilamidopropiletildimonium Etosulfato, k. entre 0,30 y 0,60 % en peso de ceramida,j. between 0.40 and 0.80% by weight of C10-40 Isoalkylamidopropylethyldimonium Etosulfate, k. between 0.30 and 0.60% by weight of ceramide,
l. agua hasta 100,00 % en peso,l. water up to 100.00% by weight,
donde dichos % en peso son con respecto al peso total de la composición.where said% by weight are with respect to the total weight of the composition.
En una realización más preferida de la invención, la composición comprende:In a more preferred embodiment of the invention, the composition comprises:
a. 3,4 % en peso de fosfatidilcolina pura,to. 3.4% by weight of pure phosphatidylcholine,
b. 0,80 % en peso de fosfatidilcoliona hidrogenada,b. 0.80% by weight of hydrogenated phosphatidylcholione,
c. 5,6 % en peso de manitol,c. 5.6% by weight of mannitol,
d. 3,2 % en peso de glicerol,d. 3.2% by weight of glycerol,
e. 1,8 % en peso de colesterol,and. 1.8% by weight of cholesterol,
f. 0,6 % en peso de sorbato potásico,F. 0.6% by weight of potassium sorbate,
g. 0,6 % en peso de benzoato sódico,g. 0.6% by weight of sodium benzoate,
h. 0,1 % en peso de sal de origen marino,h. 0.1% by weight of salt of marine origin,
i. 0,84 % en peso de dipropilengligol,i. 0.84% by weight of dipropylene glycol,
j. 0,56 % en peso de C10-40 Isoalquilamidopropiletildimonium Etosulfato,j. 0.56% by weight of C10-40 Isoalkylamidopropylethyldimonium Ethosulfate,
k. 0,40 % en peso de ceramida,k. 0.40% by weight of ceramide,
l. agua hasta 100,00 % en peso,l. water up to 100.00% by weight,
donde dichos % en peso son con respecto al peso total de la composición.where said% by weight are with respect to the total weight of the composition.
EJEMPLOSEXAMPLES
Esta invención se entenderá mejor por referencia a los ejemplos a continuación, pero aquellos expertos en la técnica apreciaran fácilmente que los ejemplos específicos detallados solamente son ilustrativos de la invención. This invention will be better understood by reference to the examples below, but those skilled in the art will readily appreciate that the detailed specific examples are only illustrative of the invention.
Ejemplo 1: Composición y forma de prepararlaExample 1: Composition and how to prepare it
* Todos los porcentajes son en peso con respecto al peso total de la composición.* All percentages are by weight with respect to the total weight of the composition.
La composición se preparó de la siguiente forma:The composition was prepared as follows:
. Se mezclaron la fosfatidilcolina, la fosfatidilcolina hidrogenada, la ceramida, el C10-40 Isoalquilamidopropiletildimonium Etosulfato, el dipropilenglicol y el colesterol, disueltos en etanol, con el manitol.. Phosphatidylcholine, hydrogenated phosphatidylcholine, ceramide, C10-40 Isoalkylamidopropylethyldimonium Ethosulfate, dipropylene glycol and cholesterol, dissolved in ethanol, were mixed with mannitol.
. Se secó la mezcla del punto 1 a vacío a temperatura controlada de 40 °C hasta eliminar el etanol.. The mixture from point 1 was dried under vacuum at a controlled temperature of 40 ° C until the ethanol was removed.
. El sólido formado se hidrató con una solución acuosa conteniendo el glicerol, el benzoato sódico, el sorbato potásico y la sal marina en agua ultra pura y se dejó hidratar durante 1h a 58 °C.. The solid formed was hydrated with an aqueous solution containing glycerol, sodium benzoate, potassium sorbate and sea salt in ultra pure water and allowed to hydrate for 1h at 58 ° C.
. La mezcla obtenida en el punto 3 se mezcló con un agitador de hélice a 600 rpm a temperatura controlada de 40 °C durante 30 min. . The mixture obtained in point 3 was mixed with a propeller stirrer at 600 rpm at a controlled temperature of 40 ° C for 30 min.
5. La disolución se homogeneizó a 15000 rpm durante 30 min a temperatura controlada de 40 °C.5. The solution was homogenized at 15000 rpm for 30 min at a controlled temperature of 40 ° C.
La composición así obtenida es homogénea y estable y constituye un excelente producto para la salud del cabello. The composition thus obtained is homogeneous and stable and constitutes an excellent product for hair health.
Claims (2)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES202130082U ES1265629Y (en) | 2021-01-20 | 2021-01-20 | Cosmetic composition of liposomes containing a quaternized derivative of 18-methyl eicosanoic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES202130082U ES1265629Y (en) | 2021-01-20 | 2021-01-20 | Cosmetic composition of liposomes containing a quaternized derivative of 18-methyl eicosanoic acid |
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| Publication Number | Publication Date |
|---|---|
| ES1265629U true ES1265629U (en) | 2021-04-19 |
| ES1265629Y ES1265629Y (en) | 2021-07-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| ES202130082U Active ES1265629Y (en) | 2021-01-20 | 2021-01-20 | Cosmetic composition of liposomes containing a quaternized derivative of 18-methyl eicosanoic acid |
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| ES1265629Y (en) | 2021-07-22 |
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