ES1162008U - Case for filling microplaces (Machine-translation by Google Translate, not legally binding) - Google Patents
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- 238000004448 titration Methods 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/56—Means for indicating position of a recipient or sample in an array
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/32—Processes for applying liquids or other fluent materials using means for protecting parts of a surface not to be coated, e.g. using stencils, resists
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/141—Preventing contamination, tampering
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
Description
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ESTUCHE PARA EL LLENADO DE MICROPLACASCASE FOR FILLING MICROPLACES
D E S C R I P C I O ND E S C R I P C I O N
SECTOR DE LA TECNICATECHNICAL SECTOR
La presente invencion se enmarca, de forma general, en los instrumentos y metodos de analisis de muestras biologicas mediante microplacas en los campos de la investigation o el ensayo cllnico, en las diversas areas relacionadas de forma general con la biotecnologla y/o la biomedicina. De forma mas especifica, la presente invencion se enmarca en los instrumentos y metodos que facilitan el llenado manual de este tipo de microplacas y permiten un mayor control de la contamination aerea y/o por aerosoles de las muestras, principalmente en los analisis basados en la reaction en cadena de la polimerasa (PCR).The present invention is framed, in general, in the instruments and methods of analysis of biological samples by microplates in the fields of research or clinical testing, in the various areas related in general to biotechnology and / or biomedicine. More specifically, the present invention is part of the instruments and methods that facilitate the manual filling of this type of microplates and allow greater control of air pollution and / or aerosol samples, mainly in the analyzes based on the polymerase chain reaction (PCR).
Posibles sectores a los que podrla pertenecer esta invencion segun la Clasificacion Internacional de Patentes:Possible sectors to which this invention could belong according to the International Patent Classification:
C12Q1/68: Bioqulmica; Tecnicas de genetica y procesos de analisis en los que intervienen acidos nucleicos; Reaccion en cadena de la polimerasa (PCR).C12Q1 / 68: Biochemistry; Genetic techniques and analysis processes in which nucleic acids are involved; Polymerase chain reaction (PCR).
C12M1/26: Bioqulmica; Tecnicas de genetica. Inoculador o preparador de muestras en equipos para enzimologla o microbiologla.C12M1 / 26: Biochemistry; Genetic techniques Inoculator or sample preparer in equipment for enzymology or microbiology.
G01N33/50: Instrumentos de medida y analisis de las propiedades flsicas y qulmicas de materiales biologicos como orina o sangre. Pruebas basadas en union a ligandos bioespeclficos; pruebas inmunologicas.G01N33 / 50: Measuring instruments and analysis of the physical and chemical properties of biological materials such as urine or blood. Tests based on binding to biospecific ligands; immunological tests
ANTECEDENTES DE LA INVENCIONBACKGROUND OF THE INVENTION
La microplaca se ha convertido en los ultimos anos en uno de los utensilios mas comunes y practicos en biomedicina, y se encuentra en muy diversos tipos de laboratorios, tanto de investigacion como de diagnostico. El llenado manual de las microplacas presenta dos problemas principales. Uno es la dificultad del seguimiento de la pauta de llenado que, en elThe microplate has become in recent years one of the most common and practical tools in biomedicine, and is found in many different types of laboratories, both research and diagnosis. Manual filling of the microplates presents two main problems. One is the difficulty of monitoring the filling pattern that, in the
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formato mas habitual de 96 pocillos, requiere un alto grado de atencion y concentration por parte del tecnico que lo realiza. Para solventar esta dificultad existen ya en el mercado dispositivos electronicos programables que iluminan desde abajo el pocillo que se debe cargar en cada momento, facilitando al tecnico su localization. El otro problema es que, durante el llenado de la microplaca, todos los pocillos permanecen destapados hasta que se completa el llenado del ultimo de ellos, lo que aumenta el riesgo de contamination cruzada, especialmente en tecnicas muy sensibles, como la reaction en cadena de la polimerasa (PCR).96-well most common format, requires a high degree of attention and concentration by the technician who performs it. To solve this difficulty, there are already programmable electronic devices on the market that illuminate from below the well that must be loaded at all times, making it easy for the technician to locate it. The other problem is that, during the filling of the microplate, all the wells remain uncapped until the filling of the last one of them is completed, which increases the risk of cross contamination, especially in very sensitive techniques, such as the chain reaction of polymerase (PCR).
La reaccion en cadena de la polimerasa (PCR) es una tecnica de biologla molecular que permite la amplification de fragmentos especlficos de ADN (acido desoxirribonucleico). Una de las principales ventajas de esta tecnica es su gran sensibilidad, que permite amplificaciones incluso con cantidades Infimas de ADN diana. Curiosamente, esta ventaja es a la vez uno de los principales inconvenientes de la PCR, ya que esta alta sensibilidad la hace muy vulnerable a la contaminacion, esto es, la entrada inadvertida y no controlada de ADN diana en una reaccion de amplificacion. La contaminacion es uno de los principales problemas de la PCR porque, cuando se detecta, invalida el analisis y, cuando no se detecta, puede dar lugar a falsos resultados positivos.The polymerase chain reaction (PCR) is a molecular biology technique that allows the amplification of specific DNA fragments (deoxyribonucleic acid). One of the main advantages of this technique is its great sensitivity, which allows amplifications even with infamous amounts of target DNA. Interestingly, this advantage is both one of the main disadvantages of PCR, since this high sensitivity makes it very vulnerable to contamination, that is, the inadvertent and uncontrolled entry of target DNA into an amplification reaction. Contamination is one of the main problems of PCR because, when detected, it invalidates the analysis and, when it is not detected, can lead to false positive results.
La contaminacion en las muestras de PCR puede tener diversos orlgenes. A veces procede de alguno de los componentes de la reaccion (tampones, reactivos, extractos, etc) o de los materiales o instrumentos con los que estos se manipulan (tubos de reaccion, puntas de pipeta, etc). En otros casos la contaminacion proviene por via aerea del ambiente en que se preparan las mezclas de reaccion. Por ejemplo, cuando se pretende amplificar ADN humano, la contaminacion puede proceder de los propios tecnicos que preparan las reacciones. Cuando se pretende amplificar ADN de virus, bacterias u otros microorganismos frecuentes en el ambiente, la contaminacion puede proceder simplemente del aire. Para evitar este tipo de contaminaciones los tecnicos se ven obligados a tomar diversas medidas preventivas, como trabajar en campanas de flujo laminar, o utilizar guantes, gafas, mascarillas, gorros, batas, y otras medidas que, en general, suelen resultar caras, incomodas y contaminantes.Contamination in the PCR samples can have different origins. Sometimes it comes from some of the reaction components (buffers, reagents, extracts, etc.) or from the materials or instruments with which they are handled (reaction tubes, pipette tips, etc.). In other cases the contamination comes from the environment in which the reaction mixtures are prepared. For example, when it is intended to amplify human DNA, the contamination can come from the technicians who prepare the reactions. When it is intended to amplify DNA from viruses, bacteria or other microorganisms frequent in the environment, the contamination can simply come from the air. To avoid this type of contamination, technicians are forced to take various preventive measures, such as working in laminar flow hoods, or wearing gloves, glasses, masks, caps, gowns, and other measures that, in general, are usually expensive, uncomfortable. and pollutants
Las microplacas de 96 pocillos presentan el riesgo anadido de una mayor probabilidad de contaminacion cruzada mediante aerosoles. La contaminacion cruzada es la que proviene de una muestra vecina que se esta analizando simultaneamente, y los aerosoles, en este caso, son las suspensiones en aire de minusculas gotas que procedentes de una muestra pueden caer en el pocillo de otra. Los principales problemas respecto a la contaminacion por aerosoles96-well microplates present the added risk of a greater likelihood of cross contamination by aerosols. The cross contamination is the one that comes from a neighboring sample that is being analyzed simultaneously, and the aerosols, in this case, are the air suspensions of tiny drops that from one sample can fall into the well of another. The main problems regarding aerosol contamination
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de estas microplacas de reaction son que los pocillos estan muy proximos entre si, y permanecen destapados hasta que todas las mezclas de reaction se completan, momento en el que todos se cubren y sellan al unlsono con una lamina transparente.of these reaction microplates are that the wells are very close to each other, and remain uncapped until all reaction mixtures are completed, at which time all are covered and sealed in unison with a transparent sheet.
EXPLICACION DE LA INVENCIONEXPLANATION OF THE INVENTION
Definiciones:Definitions:
En las descripciones de las que consta la presente invention, se llama microplaca a la placa de analisis (tambien llamada a veces placa multipocillo o placa de titulacion o placa microtituladora) que cuenta con multiples pocillos que se comportan cada uno como un pequeno tubo de ensayo independiente y permiten, por tanto, hacer multiples analisis de forma simultanea. Las microplacas se emplean principalmente en investigation o en ensayos cllnicos en biomedicina y campos relacionados. Entre sus aplicaciones mas frecuentes esta la reaction en cadena de la polimerasa (PCR) o el ensayo de inmunoabsorcion ligado a enzimas (ELISA).In the descriptions of the present invention, the analysis plate is also called microplate (also sometimes called multiwell plate or titration plate or microtiter plate) that has multiple wells that each behave like a small test tube independent and allow, therefore, to do multiple analyzes simultaneously. Microplates are mainly used in research or in clinical trials in biomedicine and related fields. Among its most frequent applications is the polymerase chain reaction (PCR) or enzyme-linked immunosorbent assay (ELISA).
En las descripciones de las que consta la presente invention, se llama biomedicina al conjunto de los diversos campos que cubren las ramas de la biologla, las ciencias medicas en general (incluidas tambien veterinaria, farmacia, etc), las ingenierlas ambientales (agronomla, ingenierla forestal, etc) o la biotecnologla, y en general, a cualquier disciplina cuyo objeto de analisis sean principalmente muestras biologicas o sus derivados.In the descriptions of the present invention, biomedicine is called the set of various fields that cover the branches of biology, medical sciences in general (including veterinary, pharmacy, etc.), environmental engineering (agronomla, engineering forestry, etc.) or biotechnology, and in general, to any discipline whose object of analysis is mainly biological samples or their derivatives.
Descripciones:Descriptions:
La presente invention consiste en un estuche o casete para contener durante su llenado las microplacas que se emplean en laboratorios tanto de investigation como de diagnostico de los diversos campos de la biomedicina. Dicho estuche cuenta con una tapa que deja al descubierto en cada momento unicamente el pocillo o los pocillos que se estan cargando mientras mantiene cubiertos los restantes. De esta forma, esta invention contribuye a evitar la contaminacion aerea y por aerosoles de las mezclas de reaccion durante el llenado de la microplaca, a la vez que facilita al operario el seguimiento de la pauta de carga. La tapa ademas puede ser opaca a ciertas longitudes de onda, lo que permite al operario trabajar a plena luz, aunque los pocillos de la microplaca contengan compuestos fotosensibles.The present invention consists of a case or cassette to contain during its filling the microplates that are used in laboratories for both research and diagnosis of the various fields of biomedicine. Said case has a lid that reveals only the well or wells that are being loaded at all times while keeping the rest covered. In this way, this invention contributes to avoid air and aerosol contamination of the reaction mixtures during the filling of the microplate, while facilitating the operator to track the loading pattern. The lid can also be opaque at certain wavelengths, which allows the operator to work in full light, although the microplate wells contain photosensitive compounds.
De forma mas detallada, el instrumento objeto de la presente invention comprende dos partes principales:In more detail, the instrument object of the present invention comprises two main parts:
1. una plataforma base que cuenta con una cavidad central en la que encaja con precision una microplaca de dimensiones estandar, y1. a base platform that has a central cavity in which a microplate of standard dimensions fits precisely, and
2. una tapa que cubre todos los pocillos de la microplaca excepto el que se este cargando en cada momento, que queda al descubierto gracias a una apertura o ventana en dicha tapa. Para que la ventana de la tapa se desplace por la microplaca a medida que se llenan los sucesivos pocillos, se proponen dos dispositivos alternativos.2. a lid that covers all the wells of the microplate except the one that is being loaded at all times, which is exposed thanks to an opening or window in said lid. In order for the lid window to move through the microplate as the successive wells are filled, two alternative devices are proposed.
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DISPOSITIVO 1. Modelo de tapa deslizante (Figuras 1, 2).DEVICE 1. Sliding cover model (Figures 1, 2).
En este modelo, la plataforma base (2) tiene unas dimensiones aproximadas de 39 cm de ancho por 28 cm de fondo y 3 cm de alto y cuenta cuenta con una cavidad central (5) en la que encaja con precision una microplaca de dimensiones estandar. La plataforma esta parcialmente 10 cubierta por una tapa semirlgida y movil (1). Esta tapa presenta una ventana central (3) que tiene, para el caso de una microplaca de 96 pocillos, una superficie de unos 9 mm de lado (o de diametro, si es circular) que deja al descubierto uno de los pocillos de la microplaca. La tapa se coloca superpuesta sobre la plataforma base de forma que se pueda deslizar en las dos dimensiones del plano. Para que se desplace de forma precisa, la tapa puede presentar unas 15 pequenas pestanas, o algun otro dispositivo similar, que encajen sobre unas gulas dispuestas en la plataforma (4). La mision de estas gulas es hacer que la ventana de la tapa se situe exactamente sobre cada uno de los pocillos de la microplaca.In this model, the base platform (2) has approximate dimensions of 39 cm wide by 28 cm deep and 3 cm high and has a central cavity (5) in which a microplate of standard dimensions fits precisely . The platform is partially covered by a semi-rigid and mobile cover (1). This cover has a central window (3) that has, for the case of a 96-well microplate, an area of about 9 mm side (or diameter, if circular) that exposes one of the microplate wells . The cover is placed superimposed on the base platform so that it can slide in the two dimensions of the plane. To move precisely, the lid can have about 15 small tabs, or some other similar device, that fit on glues arranged on the platform (4). The mission of these glues is to make the lid window sit exactly on each of the microplate wells.
Para cargar la microplaca, esta se coloca en la cavidad de la plataforma base y se cubre con la tapa de forma que la ventana de esta se situe exactamente sobre el pocillo que se vaya a 20 cargar, dejando ocultos los restantes. De esta forma, la tapa impide que los posibles aerosoles provocados por la manipulacion de la muestra correspondiente a ese pocillo lleguen al resto de los pocillos de la microplaca. Para cargar otro pocillo, la tapa se desplaza a la posicion correspondiente siguiendo las gulas trazadas en la plataforma. De esta forma, la invencion ademas de reducir los riesgos de contamination, facilita al operario el seguimiento de la pauta 25 de carga.To load the microplate, it is placed in the cavity of the base platform and covered with the lid so that its window is placed exactly on the well to be loaded, leaving the remaining ones hidden. In this way, the lid prevents the possible aerosols caused by the manipulation of the sample corresponding to that well from reaching the rest of the microplate wells. To load another well, the lid moves to the corresponding position following the glues drawn on the platform. In this way, the invention, in addition to reducing the risks of contamination, makes it easier for the operator to follow the loading pattern 25.
La ventana de la tapa debe ser mas amplia que el pocillo de la microplaca, para evitar que la punta de la pipeta roce el borde de la ventana.The lid window should be wider than the well of the microplate, to prevent the tip of the pipette from rubbing the edge of the window.
Para evitar que la tapa y la microplaca entren en contacto, el diseno del estuche debe hacer que ambas se mantengan siempre entre si a una distancia minima de unos 2-3 mm.To prevent the cover and the microplate from coming into contact, the design of the case should always keep both of them at a minimum distance of about 2-3 mm.
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DISPOSITIVO 2. Modelo de tapa con piezas moviles a modo de puzzle de piezas deslizantes (Figuras 3, 4).DEVICE 2. Cover model with movable pieces as a puzzle of sliding parts (Figures 3, 4).
En este modelo alternativo la tapadera (1) encaja sobre la plataforma base (2) que contiene la microplaca. Esta tapadera presenta un vano central del tamano de la microplaca sobre la que 35 se situa. Este vano central presenta un fino entramado que, para el caso de una microplaca deIn this alternative model the cover (1) fits on the base platform (2) that contains the microplate. This cover has a central opening of the size of the microplate on which it is placed. This central opening has a fine fabric that, in the case of a microplate of
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96 pocillos, soporta un conjunto de 95 pequenas piezas, cada una de ellas de unos 9 mm de lado (una superficie equivalente a uno de los pocillos de la microplaca). Todas las piezas presentan un saliente en dos de sus lados y un entrante hueco de tamano correspondiente en los otros dos, de forma que todas queden ensambladas entre si, pero que todas puedan desplazarse unas respecto a otras, siempre que haya un hueco disponible. Cada tapa presenta una ventana hueca (3) del tamano de una o varias de las piezas, que deja al descubierto uno o varios de los pocillos de la microplaca.96 wells, supports a set of 95 small pieces, each of them about 9 mm side (an area equivalent to one of the microplate wells). All the pieces have a projection on two of their sides and a recessed recess of corresponding size on the other two, so that they are all assembled together, but that all can move relative to each other, provided there is a gap available. Each cover has a hollow window (3) of the size of one or more of the pieces, which exposes one or more of the microplate wells.
Para cargar la microplaca, esta se coloca en la cavidad de la plataforma base y se cubre con la tapa. El operario desplaza entonces las piezas de la tapa para hacer que la ventana hueca de esta se situe exactamente sobre el pocillo que se vaya a cargar en cada momento, dejando ocultos los restantes. De esta forma, la tapa impide que los posibles aerosoles provocados por la manipulation de la muestra correspondiente a cada pocillo lleguen al resto de los pocillos de la microplaca, al tiempo que facilita al operario el seguimiento de la pauta de carga.To load the microplate, it is placed in the cavity of the base platform and covered with the lid. The operator then moves the pieces of the lid to make the hollow window of this one is placed exactly on the well that is going to be loaded in each moment, leaving the remaining ones hidden. In this way, the lid prevents the possible aerosols caused by the manipulation of the sample corresponding to each well to reach the rest of the wells of the microplate, while facilitating the operator to track the loading pattern.
Para evitar que la tapa y la microplaca entren en contacto, el diseno del estuche debe hacer que ambas se mantengan siempre entre si a una distancia minima de unos 2-3 mm.To prevent the cover and the microplate from coming into contact, the design of the case should always keep both of them at a minimum distance of about 2-3 mm.
BREVE DESCRIPCION DE LOS DIBUJOSBRIEF DESCRIPTION OF THE DRAWINGS
Para complementar la description que se esta realizando y con objeto de ayudar a una mejor comprension de las caracterlsticas de la invention, se acompana como parte integrante de dicha descripcion, un juego de dibujos en donde con caracter ilustrativo y no limitativo, se ha representado lo siguiente:To complement the description that is being carried out and in order to help a better understanding of the characteristics of the invention, a set of drawings is attached as an integral part of said description, where with an illustrative and non-limiting nature, the next:
Figura 1.- Vista casi cenital del dispositivo 1 (Modelo de tapa deslizante) de la invencion en la que se muestra la tapa movil con una ventana central y la plataforma base, con la cavidad central en la que encaja la microplaca y las gulas para la tapa.Figure 1.- Almost zenithal view of the device 1 (Sliding cover model) of the invention in which the mobile cover is shown with a central window and the base platform, with the central cavity in which the microplate and the glues for the lid
Figura 2.- Muestra otra perspectiva del dispositivo 1 de la invencion.Figure 2.- Shows another perspective of the device 1 of the invention.
Figura 3.- Vista casi frontal del dispositivo 2 (Modelo de tapa con piezas moviles) de la invencion, en la que se muestra la tapa abierta sobre la plataforma base en la que encaja la microplaca.Figure 3.- Almost frontal view of the device 2 (Cover model with movable parts) of the invention, in which the open cover is shown on the base platform on which the microplate fits.
Figura 4.- Muestra una vista casi cenital del dispositivo 2 de la invencion, en la que la tapa esta cerrada sobre la plataforma y se aprecian en ella la ensambladura de piezas moviles y laFigure 4.- Shows an almost overhead view of the device 2 of the invention, in which the lid is closed on the platform and the assembly of moving parts and the assembly can be seen therein.
ventana que dejan al descubierto.window left uncovered.
REALIZACION PREFERENTE DE LA INVENCIONPREFERRED EMBODIMENT OF THE INVENTION
55
La presente invencion se compone de dos piezas principales, muy simples estructuralmente, que pueden estar fabricadas con materiales plasticos.The present invention is composed of two main parts, very simple structurally, which can be made of plastic materials.
Las piezas que lo componen y sus materiales deben ser lavables y susceptibles de ser tratados con productos descontaminantes, como por ejemplo, los que eliminan el ADN. De esta forma, 10 este instrumento resulta reutilizable.The parts that compose it and its materials must be washable and capable of being treated with decontaminating products, such as those that eliminate DNA. In this way, this instrument is reusable.
A menudo algunos de los componentes de las reacciones que habitualmente se llevan a cabo en las microplacas son fotosensibles, lo que obliga a los tecnicos a trabajar en condiciones por debajo del optimo de iluminacion. La presente invencion puede ayudar tambien 15 a evitar este tipo de inconvenientes, si la tapa del estuche esta hecha con un material opaco a las longitudes de onda que inactivan estos reactivos.Often some of the components of the reactions that are usually carried out in the microplates are photosensitive, which forces technicians to work in conditions below the optimal lighting. The present invention can also help to avoid this type of inconvenience, if the cover of the case is made of an opaque material at the wavelengths that inactivate these reagents.
20twenty
Claims (5)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201630742U ES1162008Y (en) | 2016-06-07 | 2016-06-07 | CASE FOR FILLING MICROPLACES |
| PCT/ES2017/070408 WO2017212099A1 (en) | 2016-06-07 | 2017-06-05 | Case for filling microplates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201630742U ES1162008Y (en) | 2016-06-07 | 2016-06-07 | CASE FOR FILLING MICROPLACES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES1162008U true ES1162008U (en) | 2016-08-02 |
| ES1162008Y ES1162008Y (en) | 2016-10-24 |
Family
ID=57137679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201630742U Expired - Fee Related ES1162008Y (en) | 2016-06-07 | 2016-06-07 | CASE FOR FILLING MICROPLACES |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES1162008Y (en) |
| WO (1) | WO2017212099A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021215755A1 (en) * | 2020-04-24 | 2021-10-28 | (주)바이오니아 | Trackable precise-sample-injection device for multi-well plate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2227230A (en) * | 1989-01-21 | 1990-07-25 | Surgichem Ltd | A container for dispensing pills,tablets and capsules |
| US20070009396A1 (en) * | 2005-07-05 | 2007-01-11 | Hong Kong Ch Gene Ltd | Multi-well plate guide protector and method for multi-well dispensing |
-
2016
- 2016-06-07 ES ES201630742U patent/ES1162008Y/en not_active Expired - Fee Related
-
2017
- 2017-06-05 WO PCT/ES2017/070408 patent/WO2017212099A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017212099A1 (en) | 2017-12-14 |
| ES1162008Y (en) | 2016-10-24 |
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