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EP4414031A3 - Glp-1 receptor agonists in dementia - Google Patents

Glp-1 receptor agonists in dementia Download PDF

Info

Publication number
EP4414031A3
EP4414031A3 EP24175772.3A EP24175772A EP4414031A3 EP 4414031 A3 EP4414031 A3 EP 4414031A3 EP 24175772 A EP24175772 A EP 24175772A EP 4414031 A3 EP4414031 A3 EP 4414031A3
Authority
EP
European Patent Office
Prior art keywords
glp
receptor agonists
dementia
semaglutide
subjects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24175772.3A
Other languages
German (de)
French (fr)
Other versions
EP4414031A2 (en
Inventor
Sarah FRIEDRICH
Charlotte Christine Thim HANSEN
Lotte Bjerre Knudsen
Anna SECHER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=73172681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP4414031(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of EP4414031A2 publication Critical patent/EP4414031A2/en
Publication of EP4414031A3 publication Critical patent/EP4414031A3/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to improved medical therapies for all forms and stages of dementia involving administration of (i) GLP-1 receptor agonists to subjects with metabolic syndrome or (ii) semaglutide.
EP24175772.3A 2019-11-06 2020-11-05 Glp-1 receptor agonists in dementia Pending EP4414031A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP19207501 2019-11-06
EP20186623 2020-07-20
EP20803489.2A EP4054620B1 (en) 2019-11-06 2020-11-05 Semaglutide in the treatment of alzheimer's dementia
PCT/EP2020/081087 WO2021089678A1 (en) 2019-11-06 2020-11-05 Glp-1 receptor agonists in dementia

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP20803489.2A Division EP4054620B1 (en) 2019-11-06 2020-11-05 Semaglutide in the treatment of alzheimer's dementia

Publications (2)

Publication Number Publication Date
EP4414031A2 EP4414031A2 (en) 2024-08-14
EP4414031A3 true EP4414031A3 (en) 2025-02-05

Family

ID=73172681

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20803489.2A Active EP4054620B1 (en) 2019-11-06 2020-11-05 Semaglutide in the treatment of alzheimer's dementia
EP24175772.3A Pending EP4414031A3 (en) 2019-11-06 2020-11-05 Glp-1 receptor agonists in dementia

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20803489.2A Active EP4054620B1 (en) 2019-11-06 2020-11-05 Semaglutide in the treatment of alzheimer's dementia

Country Status (19)

Country Link
US (4) US20220280612A1 (en)
EP (2) EP4054620B1 (en)
JP (2) JP7670698B2 (en)
KR (1) KR20220110731A (en)
CN (1) CN114728042A (en)
AU (1) AU2020377469A1 (en)
BR (1) BR112022007721A2 (en)
CA (1) CA3154744A1 (en)
ES (1) ES2984177T3 (en)
HR (1) HRP20241052T1 (en)
HU (1) HUE067514T2 (en)
IL (1) IL291876A (en)
MA (1) MA57599B1 (en)
MX (1) MX2022004779A (en)
PH (1) PH12022550842A1 (en)
PL (1) PL4054620T3 (en)
RS (1) RS65780B1 (en)
TW (2) TW202519256A (en)
WO (1) WO2021089678A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL4054620T3 (en) 2019-11-06 2024-10-14 Novo Nordisk A/S Semaglutide in the treatment of alzheimer's dementia
IL295182A (en) * 2020-01-30 2022-09-01 Lilly Co Eli Therapeutic uses of dulaglutide
CN117320755A (en) * 2020-12-16 2023-12-29 香港中文大学 A method to reverse aging brain function decline
JP7813887B2 (en) 2021-12-02 2026-02-13 ケブンハウンス、ウニバーシテート Peptide drug conjugates for the treatment of neurodegenerative diseases
CN120731085A (en) * 2023-03-02 2025-09-30 甘李药业股份有限公司 Medical use of a GLP-1 compound
CN120131965A (en) * 2025-04-10 2025-06-13 瓯江实验室 Use of GLP-1 receptor agonists in the treatment of Alzheimer's disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170112897A1 (en) * 2015-10-23 2017-04-27 Cedars-Sinai Medical Center Methods for treating brain insulin resistance
WO2017112889A1 (en) * 2015-12-23 2017-06-29 The Johns Hopkins University Long-acting glp-1r agonist as a therapy of neurological and neurodegenerative conditions

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US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
BRPI9711437B8 (en) 1996-08-30 2021-05-25 Novo Nordisk As glp-1 derivatives
CA2361716C (en) 1999-02-05 2009-04-28 Emisphere Technologies, Inc. Method of preparing alkylated salicylamides
US7262325B2 (en) 2000-06-02 2007-08-28 Emisphere Technologies, Inc. Method of preparing salicylamides
ATE408414T1 (en) 2001-07-31 2008-10-15 Us Gov Health & Human Serv GLP 1 EXENDIN 4 PEPTIDE ANALOGUES AND THEIR USES
TWI362392B (en) 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
MX2008001468A (en) 2005-06-30 2008-04-07 Sod Conseils Rech Applic Glp-1 pharmaceutical compositions.
US8927015B2 (en) 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
WO2008019147A2 (en) 2006-08-04 2008-02-14 Amylin Pharmaceuticals, Inc. Use of exendins, exendin agonists and glp-1 receptor agonists for altering the concentration of fibrinogen
CN101506147B (en) 2006-09-07 2012-03-21 霍夫曼-拉罗奇有限公司 Process for the preparation of SNAC (sodium N-(8-[2-hydroxybenzoyl]-amino)octanoate)
AU2010338387B2 (en) 2009-12-16 2014-10-23 Novo Nordisk A/S Double-acylated GLP-1 derivatives
WO2011075393A2 (en) 2009-12-18 2011-06-23 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
MX377589B (en) * 2010-12-16 2025-03-10 Novo Nordisk As Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid
CN106117343B (en) 2011-04-12 2020-11-03 诺沃—诺迪斯克有限公司 Diacylated GLP-1 Derivatives
WO2013004983A1 (en) 2011-07-04 2013-01-10 Imperial Innovations Limited Novel compounds and their effects on feeding behaviour
RS60432B1 (en) * 2012-07-01 2020-07-31 Novo Nordisk As Use of long-acting glp-1 peptides
US10689429B2 (en) 2014-04-07 2020-06-23 Novo Nordisk A/S Double-acylated GLP-1 compounds
WO2016198624A1 (en) * 2015-06-12 2016-12-15 Sanofi Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
US20190142905A1 (en) 2016-04-19 2019-05-16 Ureka Sarl Peptide-oligourea foldamer compounds and methods of their use
GB201620611D0 (en) 2016-12-05 2017-01-18 Univ Of Lancaster Treatment of neurological diseases
PL4054620T3 (en) 2019-11-06 2024-10-14 Novo Nordisk A/S Semaglutide in the treatment of alzheimer's dementia
JP7761567B2 (en) 2020-02-18 2025-10-28 ノヴォ ノルディスク アー／エス Pharmaceutical preparations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170112897A1 (en) * 2015-10-23 2017-04-27 Cedars-Sinai Medical Center Methods for treating brain insulin resistance
WO2017112889A1 (en) * 2015-12-23 2017-06-29 The Johns Hopkins University Long-acting glp-1r agonist as a therapy of neurological and neurodegenerative conditions

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANDRE F BATISTA ET AL: "The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease : Liraglutide protects memory, insulin receptors, and synapses", THE JOURNAL OF PATHOLOGY, vol. 245, no. 1, 2 April 2018 (2018-04-02), pages 85 - 100, XP055682460, ISSN: 0022-3417, DOI: 10.1002/path.5056 *
LIPING ZHANG ET AL: "Semaglutide is Neuroprotective and Reduces [alpha]-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease", JOURNAL OF PARKINSON'S DISEASE, vol. 9, no. 1, 5 February 2019 (2019-02-05), NL, pages 157 - 171, XP055767444, ISSN: 1877-7171, DOI: 10.3233/JPD-181503 *
STEPHEN N. GOMPERTS,: "Lewy Body Dementias : Dementia With Lewy Bodies and Parkinson Disease Dementia", CONTINUUM - LIFELONG LEARNING IN NEUROLOGY: THE OFFICIAL CME JOURNAL OF THE AMERICAN ACADEMY OF NEUROLOGY, vol. 22, no. 2, Dementia, 1 April 2016 (2016-04-01), US, pages 435 - 463, XP055767450, ISSN: 1080-2371, DOI: 10.1212/CON.0000000000000309 *
WATSON KATHLEEN T ET AL: "Neural correlates of liraglutide effects in persons at risk for Alzheimer's disease", BEHAVIOURAL BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 356, 9 August 2018 (2018-08-09), pages 271 - 278, XP085492161, ISSN: 0166-4328, DOI: 10.1016/J.BBR.2018.08.006 *
YAN YANG ET AL: "Subcutaneous Administration of Liraglutide Ameliorates Alzheimer-Associated Tau Hyperphosphorylation in Rats with Type 2 Diabetes1", JOURNAL OF ALZHEIMER'S DISEASE, vol. 37, no. 3, 24 September 2013 (2013-09-24), NL, pages 637 - 648, XP055682486, ISSN: 1387-2877, DOI: 10.3233/JAD-130491 *
ZHANG LIPING ET AL: "Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model", NEUROPEPTIDES, CHURCHILL LIVINGSTONE, GB, vol. 71, 11 July 2018 (2018-07-11), pages 70 - 80, XP085482793, ISSN: 0143-4179, DOI: 10.1016/J.NPEP.2018.07.003 *

Also Published As

Publication number Publication date
WO2021089678A1 (en) 2021-05-14
EP4054620B1 (en) 2024-05-29
CN114728042A (en) 2022-07-08
HUE067514T2 (en) 2024-10-28
HRP20241052T1 (en) 2024-11-08
MX2022004779A (en) 2022-06-14
US20220280612A1 (en) 2022-09-08
MA57599B1 (en) 2024-06-28
IL291876A (en) 2022-06-01
EP4054620A1 (en) 2022-09-14
EP4414031A2 (en) 2024-08-14
PH12022550842A1 (en) 2023-10-09
PL4054620T3 (en) 2024-10-14
US12539326B2 (en) 2026-02-03
BR112022007721A2 (en) 2022-07-12
US20230302094A1 (en) 2023-09-28
TW202118509A (en) 2021-05-16
KR20220110731A (en) 2022-08-09
JP2025027130A (en) 2025-02-26
JP2023500032A (en) 2023-01-04
US20250099549A1 (en) 2025-03-27
TWI890704B (en) 2025-07-21
EP4054620C0 (en) 2024-05-29
ES2984177T3 (en) 2024-10-29
CA3154744A1 (en) 2021-05-14
RS65780B1 (en) 2024-08-30
US20240207364A1 (en) 2024-06-27
JP7670698B2 (en) 2025-04-30
AU2020377469A1 (en) 2022-04-28
TW202519256A (en) 2025-05-16

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