EP4308220A4 - Pairing vagus nerve stimulation with emg-controlled functional electrical stimulation to enhance neuroplasticity and recovery - Google Patents

Pairing vagus nerve stimulation with emg-controlled functional electrical stimulation to enhance neuroplasticity and recovery Download PDF

Info

Publication number: EP4308220A4
Authority: EP; European Patent Office
Prior art keywords: emg; recovery; vagus nerve; stimulation; functional electrical
Prior art date: 2021-03-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP22772278.2A

Other languages

German (de)

French (fr)

Other versions

EP4308220A1 (en

Inventor

Eric Meyers

Michael DARROW

David FRIEDENBERG

Lauren WENGERD

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Battelle Memorial Institute Inc

Original Assignee

Battelle Memorial Institute Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2021-03-19

Filing date

2022-03-18

Publication date

2024-08-28

2022-03-18 Application filed by Battelle Memorial Institute Inc filed Critical Battelle Memorial Institute Inc

2024-01-24 Publication of EP4308220A1 publication Critical patent/EP4308220A1/en

2024-08-28 Publication of EP4308220A4 publication Critical patent/EP4308220A4/en

Status Pending legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/251—Means for maintaining electrode contact with the body
- A61B5/256—Wearable electrodes, e.g. having straps or bands
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/296—Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0484—Garment electrodes worn by the patient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36031—Control systems using physiological parameters for adjustment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A61N1/36139—Control systems using physiological parameters with automatic adjustment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/389—Electromyography [EMG]
- A61B5/397—Analysis of electromyograms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0452—Specially adapted for transcutaneous muscle stimulation [TMS]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Radiology & Medical Imaging (AREA)
Biophysics (AREA)
Heart & Thoracic Surgery (AREA)
Physiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pathology (AREA)
Physics & Mathematics (AREA)
Medical Informatics (AREA)
Molecular Biology (AREA)
Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dentistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Electrotherapy Devices (AREA)

EP22772278.2A 2021-03-19 2022-03-18 Pairing vagus nerve stimulation with emg-controlled functional electrical stimulation to enhance neuroplasticity and recovery Pending EP4308220A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US202163163237P	2021-03-19	2021-03-19
PCT/US2022/020920 WO2022198029A1 (en)	2021-03-19	2022-03-18	Pairing vagus nerve stimulation with emg-controlled functional electrical stimulation to enhance neuroplasticity and recovery

Publications (2)

Publication Number	Publication Date
EP4308220A1 EP4308220A1 (en)	2024-01-24
EP4308220A4 true EP4308220A4 (en)	2024-08-28

Family

ID=83285508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP22772278.2A Pending EP4308220A4 (en)	2021-03-19	2022-03-18	Pairing vagus nerve stimulation with emg-controlled functional electrical stimulation to enhance neuroplasticity and recovery

Country Status (5)

Country	Link
US (1)	US12337178B2 (en)
EP (1)	EP4308220A4 (en)
AU (1)	AU2022240751B2 (en)
CA (1)	CA3210817A1 (en)
WO (1)	WO2022198029A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20230109161A1 (en) *	2021-10-04	2023-04-06	Battelle Memorial Institute	Systems and methods for reducing spasticity after neurological injury

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8706241B2 (en) *	2005-10-19	2014-04-22	Advanced Neuromodulation Systems, Inc.	System for patent interactive neural stimulation with robotic facilitation of limb movement
EP3653260A1 (en) *	2018-11-13	2020-05-20	GTX medical B.V.	Sensor in clothing of limbs or footwear
US20200405188A1 (en) *	2019-06-28	2020-12-31	Battelle Memorial Institute	Neurosleeve for closed loop emg-fes based control of pathological tremors
US20210038880A1 (en) *	2015-12-28	2021-02-11	Cogniguard Medical Holdings Limited	System and method for treating various neurological disorders using synchronized nerve activation
WO2021178914A1 (en) *	2020-03-06	2021-09-10	Northwell Health, Inc.	System and method for determining user intention from limb or body motion or trajectory to control neuromuscular stimuation or prosthetic device operation

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Publication number	Priority date	Publication date	Assignee	Title
US9333347B2 (en) *	2010-08-19	2016-05-10	ElectroCore, LLC	Devices and methods for non-invasive electrical stimulation and their use for vagal nerve stimulation on the neck of a patient
EP4620515A3 (en) *	2011-10-13	2025-12-03	Microtransponder, Inc.	System for pairing vagus nerve stimulation with motor therapy in stroke patients
US9884179B2 (en)	2012-12-05	2018-02-06	Bbattelle Memorial Institute	Neural sleeve for neuromuscular stimulation, sensing and recording
EP3970787B1 (en)	2015-06-02	2022-10-05	Battelle Memorial Institute	Neural sleeve for neuromuscular stimulation, sensing and recording
US20200040622A1 (en)	2018-08-03	2020-02-06	Magna BOCO GmbH	Closure system for motor vehicle having vehicle striker with vibration dampening assembly
EP4161629A1 (en)	2020-06-06	2023-04-12	Battelle Memorial Institute	Portable and wearable hand-grasp neuro-orthosis

2022
- 2022-03-18 EP EP22772278.2A patent/EP4308220A4/en active Pending
- 2022-03-18 CA CA3210817A patent/CA3210817A1/en active Pending
- 2022-03-18 US US17/698,350 patent/US12337178B2/en active Active
- 2022-03-18 AU AU2022240751A patent/AU2022240751B2/en active Active
- 2022-03-18 WO PCT/US2022/020920 patent/WO2022198029A1/en not_active Ceased

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8706241B2 (en) *	2005-10-19	2014-04-22	Advanced Neuromodulation Systems, Inc.	System for patent interactive neural stimulation with robotic facilitation of limb movement
US20210038880A1 (en) *	2015-12-28	2021-02-11	Cogniguard Medical Holdings Limited	System and method for treating various neurological disorders using synchronized nerve activation
EP3653260A1 (en) *	2018-11-13	2020-05-20	GTX medical B.V.	Sensor in clothing of limbs or footwear
US20200405188A1 (en) *	2019-06-28	2020-12-31	Battelle Memorial Institute	Neurosleeve for closed loop emg-fes based control of pathological tremors
WO2021178914A1 (en) *	2020-03-06	2021-09-10	Northwell Health, Inc.	System and method for determining user intention from limb or body motion or trajectory to control neuromuscular stimuation or prosthetic device operation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2022198029A1 *

Also Published As

Publication number	Publication date
US20220296901A1 (en)	2022-09-22
CA3210817A1 (en)	2022-09-22
WO2022198029A1 (en)	2022-09-22
AU2022240751A1 (en)	2023-09-21
EP4308220A1 (en)	2024-01-24
US12337178B2 (en)	2025-06-24
AU2022240751B2 (en)	2025-05-08

Publication	Publication Date	Title
IL298193B1 (en)	2023-09-01	Systems and methods for vagus nerve stimulation
EP4338790A3 (en)	2024-06-19	Vagus nerve stimulation system
WO2010057046A3 (en)	2010-08-26	Multiplexed multi-electrode neurostimulation devices
IL291272A (en)	2022-05-01	Neuromodulation of the glossopharyngeal nerve to improve sleep disordered breathing
EP2986338B8 (en)	2021-12-15	Transcutaneous electrical nerves stimulator with automatic detection of user sleep-wake state
WO2013103579A3 (en)	2013-10-10	Neural stimulation device with insulating sheath
MX364500B (en)	2019-04-29	Non-invasive nerve stimulation system.
MX2012010841A (en)	2013-01-29	Charge-enhanced neural electric stimulation system.
WO2012100260A3 (en)	2012-11-01	A parylene-based microelectrode array implant for spinal cord stimulation
WO2010144578A3 (en)	2011-03-31	Nerve cuff with pocket for leadless stimulator
WO2010091435A3 (en)	2010-11-25	Multiplexed multi-electrode neurostimulation devices with integrated circuit having integrated electrodes
WO2011139632A3 (en)	2012-04-19	Header for implantable pulse generator and method of making same
EP3180070A4 (en)	2018-02-07	Implantable lead affixation structure for nerve stimulation to alleviate bladder dysfunction and other indications
WO2014186122A3 (en)	2015-01-15	Systems and methods for making tip electrodes for leads of electrical stimulation systems
WO2013046043A3 (en)	2013-07-04	Electrode configuration for implantable modulator
CL2009001634U1 (en)	2011-06-10	A patch with an electrical transcutaneous nerve stimulator device comprises an elongated band that has: a central module with a current control panel between two electrodes, two flanges on both sides of the module each of which is associated with one of the electrodes.
WO2009062114A3 (en)	2009-08-27	Cochlear stimulation device comprising a flexible electrode array
WO2013061304A3 (en)	2013-07-18	Transcutaneous electrical nerve stimulation of the knee
EP3458150A4 (en)	2020-01-22	Transdermal electrical stimulation at the neck to induce neuromodulation
CA218818S (en)	2023-03-02	Electrode assembly for electrical stimulation
AU201813344S (en)	2018-06-04	Transcutaneous Electrical Nerve Stimulation (Tens) Device
WO2007117800A3 (en)	2008-01-24	Electrodes for transcutaneous electrical nerve stimulator
EP3242715A4 (en)	2018-09-26	Enhanced transcutaneous electrical nerve stimulator with automatic detection of leg orientation and motion for enhanced sleep analysis
EP4308220A4 (en)	2024-08-28	Pairing vagus nerve stimulation with emg-controlled functional electrical stimulation to enhance neuroplasticity and recovery
UA116181C2 (en)	2018-02-12	Panel equipped with a photovoltaic device

Legal Events

Date	Code	Title	Description
2022-09-23	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2023-12-22	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2023-12-22	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2024-01-24	17P	Request for examination filed	Effective date: 20230908
2024-01-24	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2024-03-13	P01	Opt-out of the competence of the unified patent court (upc) registered	Effective date: 20240202
2024-06-26	DAV	Request for validation of the european patent (deleted)
2024-06-26	DAX	Request for extension of the european patent (deleted)
2024-08-28	A4	Supplementary search report drawn up and despatched	Effective date: 20240730
2024-08-28	RIC1	Information provided on ipc code assigned before grant	Ipc: A61N 1/36 20060101AFI20240724BHEP