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EP4292520A3 - Systems, devices and methods for non-invasive hematological measurements - Google Patents

Systems, devices and methods for non-invasive hematological measurements Download PDF

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Publication number
EP4292520A3
EP4292520A3 EP23207252.0A EP23207252A EP4292520A3 EP 4292520 A3 EP4292520 A3 EP 4292520A3 EP 23207252 A EP23207252 A EP 23207252A EP 4292520 A3 EP4292520 A3 EP 4292520A3
Authority
EP
European Patent Office
Prior art keywords
imaging device
images
time
analysis
capillary structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23207252.0A
Other languages
German (de)
French (fr)
Other versions
EP4292520A2 (en
Inventor
Carlos CASTRO-GONZALES
Ian Butterworth
Aurelien Bourquard
Alvaro Sanchez-Ferro
Jason TUCKER-SCHWARTZ
Alberto PABLO-TRINIDAD
Maria J. LEDMESMA-CARBAYO
Tom VETTENBURG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Politecnica de Madrid
Massachusetts Institute of Technology
Original Assignee
Universidad Politecnica de Madrid
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Politecnica de Madrid, Massachusetts Institute of Technology filed Critical Universidad Politecnica de Madrid
Publication of EP4292520A2 publication Critical patent/EP4292520A2/en
Publication of EP4292520A3 publication Critical patent/EP4292520A3/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/489—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6825—Hand
    • A61B5/6826—Finger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G06T7/0014—Biomedical image inspection using an image reference approach
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V40/00—Recognition of biometric, human-related or animal-related patterns in image or video data
    • G06V40/10—Human or animal bodies, e.g. vehicle occupants or pedestrians; Body parts, e.g. hands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10016—Video; Image sequence
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10141—Special mode during image acquisition
    • G06T2207/10152—Varying illumination
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20081—Training; Learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20084—Artificial neural networks [ANN]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30101—Blood vessel; Artery; Vein; Vascular
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V40/00—Recognition of biometric, human-related or animal-related patterns in image or video data
    • G06V40/10—Human or animal bodies, e.g. vehicle occupants or pedestrians; Body parts, e.g. hands
    • G06V40/14—Vascular patterns
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V40/00—Recognition of biometric, human-related or animal-related patterns in image or video data
    • G06V40/10—Human or animal bodies, e.g. vehicle occupants or pedestrians; Body parts, e.g. hands
    • G06V40/15—Biometric patterns based on physiological signals, e.g. heartbeat, blood flow
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Signal Processing (AREA)
  • Psychiatry (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Evolutionary Computation (AREA)
  • Fuzzy Systems (AREA)
  • Mathematical Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Quality & Reliability (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Multimedia (AREA)
  • Human Computer Interaction (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Image Analysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Processing (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

A system for non-invasive in vivo analysis of blood cell dynamics. The system comprises a platform to receive a body portion of a user during use, the body portion having capillary structure; an imaging device coupled to the platform and to acquire a time-lapse series of images of the capillary structure, wherein each image resolves multiple capillaries; and an imaging objective coupled to the imaging device. The imaging device is configured to communicate with a controller that is adapted to: receive the time-lapse series of images of the capillary structure from the imaging device; and process the time-lapse series of images to perform the analysis of blood cell dynamics for one or more capillaries of the multiple capillaries. The analysis of blood cell dynamics comprises detecting passage in a capillary of a cell that exhibits a contrast in absorption relative to red blood cells.
EP23207252.0A 2017-10-16 2018-10-16 Systems, devices and methods for non-invasive hematological measurements Pending EP4292520A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762572738P 2017-10-16 2017-10-16
PCT/US2018/056100 WO2019079310A1 (en) 2017-10-16 2018-10-16 Systems, devices and methods for non-invasive hematological measurements
EP18867626.6A EP3697294B1 (en) 2017-10-16 2018-10-16 System and method for non-invasive hematological measurements

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP18867626.6A Division EP3697294B1 (en) 2017-10-16 2018-10-16 System and method for non-invasive hematological measurements
EP18867626.6A Division-Into EP3697294B1 (en) 2017-10-16 2018-10-16 System and method for non-invasive hematological measurements

Publications (2)

Publication Number Publication Date
EP4292520A2 EP4292520A2 (en) 2023-12-20
EP4292520A3 true EP4292520A3 (en) 2024-07-10

Family

ID=66173433

Family Applications (2)

Application Number Title Priority Date Filing Date
EP23207252.0A Pending EP4292520A3 (en) 2017-10-16 2018-10-16 Systems, devices and methods for non-invasive hematological measurements
EP18867626.6A Active EP3697294B1 (en) 2017-10-16 2018-10-16 System and method for non-invasive hematological measurements

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18867626.6A Active EP3697294B1 (en) 2017-10-16 2018-10-16 System and method for non-invasive hematological measurements

Country Status (7)

Country Link
US (3) US11244452B2 (en)
EP (2) EP4292520A3 (en)
JP (2) JP7595320B2 (en)
CN (1) CN111491555B (en)
AU (2) AU2018352526B2 (en)
CA (1) CA3079209A1 (en)
WO (1) WO2019079310A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10789710B2 (en) 2015-05-15 2020-09-29 Gauss Surgical, Inc. Methods and systems for characterizing fluids from a patient
JP2020525801A (en) * 2017-06-23 2020-08-27 ボヤント ダイアグノスティックス インコーポレイテッドＶｏｙａｎｔ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． Medical diagnostic system and method
EP4292520A3 (en) 2017-10-16 2024-07-10 Massachusetts Institute of Technology Systems, devices and methods for non-invasive hematological measurements
EP3620098B1 (en) * 2018-09-07 2021-11-03 Ambu A/S Enhancing the visibility of blood vessels in colour images
US10799182B2 (en) * 2018-10-19 2020-10-13 Microsoft Technology Licensing, Llc Video-based physiological measurement using neural networks
CN109602401B (en) * 2019-01-28 2021-08-27 徐州市心血管病研究所 Microvascular hemodynamic parameter analyzer and analysis method
JP2020154828A (en) * 2019-03-20 2020-09-24 富士通株式会社 Data complement program, data complement method and data complement device
US11754824B2 (en) * 2019-03-26 2023-09-12 Active Medical, BV Method and apparatus for diagnostic analysis of the function and morphology of microcirculation alterations
CN116211296A (en) * 2019-07-24 2023-06-06 麻省理工学院 Finger Inserts for Nailfold Imaging Devices
CN111145201B (en) * 2019-12-26 2021-10-08 中南大学 A Robust and Fast UAV Photogrammetry Mark Detection and Localization Method
US12230016B2 (en) * 2020-03-03 2025-02-18 Google Llc Explanation of machine-learned models using image translation
HUP2000138A1 (en) * 2020-04-22 2021-10-28 Mediner Gyogyszerkereskedelmi Method and system for optical examination of nails
JP7565493B2 (en) * 2020-05-28 2024-10-11 レウコ・ラボズ・インコーポレイテッド Method for detecting white blood cells and/or white blood cell subtypes from non-invasive capillary videos and method for determining red blood cell concentration from non-invasive capillary videos - Patents.com
US11270438B2 (en) * 2020-06-12 2022-03-08 Samasource Impact Sourcing, Inc. System and method for triggering machine learning (ML) annotation model retraining
CN114073494A (en) * 2020-08-19 2022-02-22 京东方科技集团股份有限公司 Leukocyte detection method, system, electronic device, and computer-readable medium
US20230389835A1 (en) * 2020-08-23 2023-12-07 My-Or Diagnostics Ltd. Apparatus and method for determining hemoglobin levels
KR102403577B1 (en) * 2020-08-27 2022-05-31 (주)한국아이티에스 Noninvasive hba1c measurement system and method using monte carlo simulation
CN116847783A (en) * 2020-12-18 2023-10-03 约翰霍普金斯大学 Compact capillary microscope for non-invasive blood analysis
JP2022098405A (en) * 2020-12-21 2022-07-01 国立研究開発法人理化学研究所 Blood abnormality prediction apparatus, blood abnormality prediction method and program
WO2022182603A1 (en) * 2021-02-23 2022-09-01 West Virginia University Board of Governors on behalf of West Virginia University Radon transform and persistent homology patient barcodes
CN113705312A (en) * 2021-04-02 2021-11-26 腾讯科技（深圳）有限公司 Hemoglobin detection method, device and computer readable storage medium
JP7602438B2 (en) * 2021-07-12 2024-12-18 富士フイルム株式会社 Medical imaging apparatus and method of operation thereof
CN117999026A (en) * 2021-08-02 2024-05-07 露科实验室股份有限公司 Automated system and method for acquiring images of one or more capillaries in a capillary bed
CN115054209B (en) * 2022-04-14 2023-09-26 杭州华视诺维医疗科技有限公司 Multi-parameter physiological information detection system and method based on intelligent mobile equipment
WO2024182397A1 (en) * 2023-02-28 2024-09-06 Life Technologies Corporation Systems and methods for pixel detection
WO2025160489A1 (en) * 2024-01-25 2025-07-31 10X Genomics, Inc. Systems and methods for image segmentation using multiple stain indicators
CN118469957A (en) * 2024-05-17 2024-08-09 北京信息科技大学 A method and device for counting white blood cells in nail fold microcirculation based on microscopic imaging
CN120298304A (en) * 2025-03-06 2025-07-11 北京信息科技大学 Portable nailfold microcirculatory leukocyte real-time non-invasive monitoring and counting method and device based on deep learning
CN120235870B (en) * 2025-05-30 2025-10-14 中国医学科学院北京协和医院 Intelligent pelvic floor muscle state assessment method by utilizing medical imaging analysis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120089031A1 (en) * 2003-10-03 2012-04-12 Can Ince Systems and methods for sidesstream dark field imaging
WO2016086023A1 (en) * 2014-11-24 2016-06-02 Massachusetts Institute Of Technology Systems, apparatus, and methods for analyzing blood cell dynamics

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US534211A (en) 1895-02-12 Charles h
US2588528A (en) 1948-07-27 1952-03-11 California Thimble Corp Finger shaped thimble
US2548378A (en) 1949-12-06 1951-04-10 Ewald H Kleinfeld Finger splint
US4425924A (en) * 1981-09-29 1984-01-17 Riva Charles E Blood velocity measurement in retinal capillaries utilizing the blue field entoptic phenomenon
US4998533A (en) 1986-07-15 1991-03-12 Winkelman James W Apparatus and method for in vivo analysis of red and white blood cell indices
US4694843A (en) 1986-10-07 1987-09-22 Casenhiser Elaine J Fingertip cover
US5596987A (en) 1988-11-02 1997-01-28 Noninvasive Technology, Inc. Optical coupler for in vivo examination of biological tissue
US5218207A (en) 1989-01-19 1993-06-08 Futrex, Inc. Using led harmonic wavelengths for near-infrared quantitative
US5086229A (en) 1989-01-19 1992-02-04 Futrex, Inc. Non-invasive measurement of blood glucose
US5237178A (en) 1990-06-27 1993-08-17 Rosenthal Robert D Non-invasive near-infrared quantitative measurement instrument
US5068536A (en) 1989-01-19 1991-11-26 Futrex, Inc. Method for providing custom calibration for near infrared instruments for measurement of blood glucose
US5365066A (en) 1989-01-19 1994-11-15 Futrex, Inc. Low cost means for increasing measurement sensitivity in LED/IRED near-infrared instruments
US5204532A (en) 1989-01-19 1993-04-20 Futrex, Inc. Method for providing general calibration for near infrared instruments for measurement of blood glucose
US5077476A (en) 1990-06-27 1991-12-31 Futrex, Inc. Instrument for non-invasive measurement of blood glucose
US5362966A (en) 1990-06-27 1994-11-08 Rosenthal Robert D Measurement of finger temperature in near-infrared quantitative measurement instrument
US5436455A (en) 1990-06-27 1995-07-25 Futrex Inc. Non-invasive near-infrared quantitative measurement instrument
US5638818A (en) 1991-03-21 1997-06-17 Masimo Corporation Low noise optical probe
IL107396A (en) 1992-11-09 1997-02-18 Boehringer Mannheim Gmbh Method and apparatus for analytical determination of glucose in a biological matrix
US5452717A (en) 1993-07-14 1995-09-26 Masimo Corporation Finger-cot probe
US5598842A (en) 1993-09-03 1997-02-04 Toa Medical Electronics Co., Ltd. Non-invasive blood analyzer and method using the same
JP3497012B2 (en) 1994-11-30 2004-02-16 謙 石原 Non-invasive blood analyzer
US5791345A (en) * 1993-09-03 1998-08-11 Toa Medical Electronics Co., Ltd. Non-invasive blood analyzer
JP3364323B2 (en) 1994-05-17 2003-01-08 謙 石原 Non-invasive blood analyzer
US5582705A (en) * 1995-05-19 1996-12-10 Iowa State University Research Foundation, Inc. Multiplexed capillary electrophoresis system
KR100269563B1 (en) 1995-10-23 2000-12-01 사이토메트릭스, 인코오포레이티드 Apparatus for reflected imaging analysis
US6041247A (en) 1995-11-29 2000-03-21 Instrumentarium Corp Non-invasive optical measuring sensor and measuring method
IL120881A (en) 1996-07-30 2002-09-12 It M R Medic L Cm 1997 Ltd Method and apparatus for the non-invasive continous monitoring of peripheral arterial tone
JP4136017B2 (en) 1996-09-19 2008-08-20 シスメックス株式会社 Particle analyzer
MY117121A (en) 1997-01-09 2004-05-31 Nec Corp Finger fixing apparatus.
US5855212A (en) 1997-10-23 1999-01-05 Walker; Alvin Miller Thumb and finger nail polish remover device
US6179159B1 (en) 1998-01-26 2001-01-30 Mariruth D. Gurley Communicable disease barrier digit cover and dispensing package therefor
US6424851B1 (en) 1998-10-13 2002-07-23 Medoptix, Inc. Infrared ATR glucose measurement system (II)
US6438396B1 (en) 1998-11-05 2002-08-20 Cytometrics, Inc. Method and apparatus for providing high contrast imaging
US6358208B1 (en) * 1998-11-21 2002-03-19 Philipp Lang Assessment of cardiovascular performance using ultrasound methods and devices that interrogate interstitial fluid
US6154285A (en) 1998-12-21 2000-11-28 Secugen Corporation Surface treatment for optical image capturing system
AU4022801A (en) 1999-09-23 2001-04-24 Richard G. Nadeau Medical applications of orthogonal polarization spectral imaging
US6213952B1 (en) 1999-09-28 2001-04-10 Orsense Ltd. Optical device for non-invasive measurement of blood related signals utilizing a finger holder
US6687521B2 (en) 2000-02-03 2004-02-03 Hamamatsu Photonics K.K. Noninvasion biological optical measuring instrument, measured portion holding device, and method for manufacturing the same
US20090018417A1 (en) 2001-01-19 2009-01-15 Wei-Kung Wang Apparatus monitoring signal in situ
CN1316699C (en) 2000-07-19 2007-05-16 浜松光子学株式会社 Light-emitting device drive circuit
JP2002277747A (en) 2001-03-21 2002-09-25 Juyu International Co Capillary blood observation method and automatic measuring device
US6634367B2 (en) 2002-03-25 2003-10-21 Kathleen Hunter Abraham Sealing enclosure for finger tips
CN1166951C (en) 2002-08-28 2004-09-15 彭黎明 Woundless blood cell parameter measuring method
GB0225791D0 (en) 2002-11-05 2002-12-11 Kratos Analytical Ltd Charged particle spectrometer and detector therefor
US20070299322A1 (en) 2003-11-18 2007-12-27 Sony Corporation Input Device, Input Method, And Electronic Device
US7333186B2 (en) 2004-03-17 2008-02-19 Matsushita Electric Industrial Co., Ltd. Method and device for measuring biological information
US7251836B2 (en) 2004-06-08 2007-08-07 Wanda Santiago Finger cover
CA2634466A1 (en) * 2004-12-22 2006-06-29 Bio-Tree Systems, Inc. Medical imaging methods and apparatus for diagnosis and monitoring of diseases and uses therefor
US20060161063A1 (en) 2005-01-19 2006-07-20 Yio-Wha Shau System and method for real-time microcirculation diagnosis
US20070092115A1 (en) * 2005-10-26 2007-04-26 Usher David B Method and system for detecting biometric liveness
US7991210B2 (en) * 2005-11-23 2011-08-02 Vital Images, Inc. Automatic aortic detection and segmentation in three-dimensional image data
JP5095986B2 (en) 2005-11-30 2012-12-12 学校法人慶應義塾 Non-nail invasive blood substance measuring device and nail plate transpiration device
JP2007215951A (en) 2006-02-20 2007-08-30 Sony Ericsson Mobilecommunications Japan Inc Vein authentication assisting panel
AU2007226129A1 (en) 2006-03-10 2007-09-20 Noam Asna Automated sampling and analysis using a personal sampler device
US7477924B2 (en) 2006-05-02 2009-01-13 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US9646415B2 (en) 2006-05-16 2017-05-09 Underground Imaging Technologies, Inc. System and method for visualizing multiple-sensor subsurface imaging data
JP5058913B2 (en) 2007-08-09 2012-10-24 シャープ株式会社 Image processing method and particle size distribution measuring method using the same
US8366652B2 (en) 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
EP2203733B1 (en) * 2007-10-25 2017-05-03 Washington University in St. Louis Confocal photoacoustic microscopy with optical lateral resolution
US20090204044A1 (en) 2008-02-07 2009-08-13 Catherine Benison Finger splint assembly and method of treating mallet finger
US8842900B2 (en) 2008-10-28 2014-09-23 Sysmex Corporation Specimen processing system and blood cell image classifying apparatus
WO2010058872A1 (en) 2008-11-24 2010-05-27 Young-Tae Lee Thimble and gloves for working
US10489673B2 (en) 2009-04-03 2019-11-26 Siemens Healthcare Gmbh System and method for detecting landmarks in a three-dimensional image volume
US8805051B2 (en) 2009-04-07 2014-08-12 Virginia Commonwealth University Image processing and machine learning for diagnostic analysis of microcirculation
US8423117B2 (en) 2009-06-22 2013-04-16 General Electric Company System and method to process an acquired image of a subject anatomy to differentiate a portion of subject anatomy to protect relative to a portion to receive treatment
JP5767775B2 (en) * 2009-07-06 2015-08-19 富士フイルム株式会社 Endoscope device
US20110081056A1 (en) 2009-10-05 2011-04-07 Salafia Carolyn M Automated placental measurement
CN104330346B (en) 2009-12-04 2017-04-12 生命技术公司 Method FOR ACOUSTIC FLOW CYTOMETRY
US9706138B2 (en) 2010-04-23 2017-07-11 Flir Systems, Inc. Hybrid infrared sensor array having heterogeneous infrared sensors
EP2385474A1 (en) 2010-05-07 2011-11-09 TomTec Imaging Systems GmbH Method for analysing medical data
US8731262B2 (en) 2010-06-03 2014-05-20 Siemens Medical Solutions Usa, Inc. Medical image and vessel characteristic data processing system
US8977013B2 (en) 2010-07-12 2015-03-10 The Institute For Diagnostic Imaging Research, University Of Windsor Biometric sensor and method for generating a three-dimensional representation of a portion of a finger
CN103228200A (en) * 2010-10-25 2013-07-31 史提芬·维杜纳 Diagnosis, prevention and prognosis of Alzheimer's disease, brain trauma, macular degeneration and multiple neurodegenerative disorders and eye diseases Device and method for detecting amyloid in retina
JP5702991B2 (en) 2010-11-19 2015-04-15 キヤノン株式会社 Image processing apparatus and image processing method
WO2012112641A1 (en) 2011-02-15 2012-08-23 Microbix Biosystems Inc. Methods, systems, and apparatus for performing flow cytometry
US9202127B2 (en) 2011-07-08 2015-12-01 Qualcomm Incorporated Parallel processing method and apparatus for determining text information from an image
KR101273692B1 (en) 2011-09-09 2013-06-17 스타링포스 주식회사 Method for anaiysis of nail capillary image
US8848996B2 (en) * 2012-02-17 2014-09-30 Siemens Medical Solutions Usa, Inc. System for suppressing vascular structure in medical images
JP2013169296A (en) 2012-02-20 2013-09-02 Canon Inc Image processing apparatus and image processing method
US8908797B2 (en) 2012-03-07 2014-12-09 Samsung Electronics Co., Ltd. Apparatus and method for time alignment of an envelope tracking power amplifier
US9357916B2 (en) 2012-05-10 2016-06-07 Carl Zeiss Meditec, Inc. Analysis and visualization of OCT angiography data
WO2013173446A1 (en) 2012-05-15 2013-11-21 1087 Systems, Inc. Cytometry system with interferometric measurement
US8855430B1 (en) * 2012-05-30 2014-10-07 Google Inc. Refining image annotations
KR101452576B1 (en) 2012-07-03 2014-10-21 곽명수 the supplementary photographing device and the health detecting method using both mobile phone and the device
US9855009B2 (en) 2012-07-15 2018-01-02 Cnoga Medical Ltd. Apparatus for measuring blood characteristics for deployment on a host device having a digital sensor
EP3495799B1 (en) 2012-07-25 2023-09-06 Labrador Diagnostics LLC A system for imaging a biological sample
JP2014045868A (en) * 2012-08-30 2014-03-17 Canon Inc Interactive controller
US8957374B2 (en) 2012-09-28 2015-02-17 Corning Incorporated Systems and methods for measuring birefringence in glass and glass-ceramics
US9217714B2 (en) 2012-12-06 2015-12-22 Seagate Technology Llc Reflective surfaces for surface features of an article
JP6542130B2 (en) 2013-01-28 2019-07-10 オスロ ユニヴェルジテットサイケフス ホーエフ Evaluation of circulatory failure
US9445057B2 (en) 2013-02-20 2016-09-13 Magna Electronics Inc. Vehicle vision system with dirt detection
JP6200168B2 (en) * 2013-02-28 2017-09-20 キヤノン株式会社 Image processing apparatus and image processing method
JP6092659B2 (en) 2013-02-28 2017-03-08 キヤノン株式会社 Image processing apparatus and image processing method
US9424395B2 (en) 2013-03-04 2016-08-23 Heartflow, Inc. Method and system for sensitivity analysis in modeling blood flow characteristics
KR101802626B1 (en) * 2013-03-15 2017-11-28 아이리스 인터내셔널 인크. Method and composition for staining and sample processing
US20150141766A1 (en) * 2013-09-30 2015-05-21 Flfi-Tfch Ltd. Apparatus and method for optical measurement of cardiovascular recovery and/or repiration rate
JP6608141B2 (en) 2014-01-24 2019-11-20 国立大学法人九州工業大学 Health condition evaluation support system
US10198817B2 (en) 2014-04-17 2019-02-05 The Trustees Of Columbia University In The City Of New York Technologies for diagnosing neurological or psychiatric illnesses
US10284486B2 (en) 2014-07-10 2019-05-07 Oracle International Corporation System and method for resource isolation and consumption in a multitenant application server environment
JP2016086842A (en) * 2014-10-29 2016-05-23 キヤノン株式会社 Image processing apparatus and image processing method
WO2016097979A1 (en) * 2014-12-15 2016-06-23 Koninklijke Philips N.V. Approach for measuring capillary refill time
JP6551729B2 (en) 2015-04-20 2019-07-31 あっと株式会社 Capillary blood vessel image processing method and image processing program, and capillary blood vessel analysis diagnostic device
WO2016194718A1 (en) * 2015-06-05 2016-12-08 ソニー株式会社 Image processing device, image processing method, and surgical system
JP6872758B2 (en) * 2015-11-01 2021-05-19 エルフィ−テック エルティーディー．Ｅｌｆｉ−Ｔｅｃｈ Ｌｔｄ． Methods and devices for hemodynamic characterization of neurological or compatible states by dynamic light scattering (DLS)
US9772282B2 (en) 2015-11-12 2017-09-26 Massachusetts Institute Of Technology System for wide field-of-view, highly oblique illumination microscopy for scatter-based discrimination of cells
JP2017097711A (en) 2015-11-26 2017-06-01 国立大学法人九州工業大学 Scalp capillary quantification system, scalp capillary quantification program, scalp evaluation system, and scalp evaluation program
CA3014288A1 (en) * 2016-01-21 2017-07-27 Indiana University Research And Technology Corporation Treatment and prevention of retinal vascular disease by photocoagulation
CA3022798A1 (en) 2016-05-04 2017-11-09 LabThroughput LLC System and method for distinguishing blood components
US20170367924A1 (en) 2016-06-28 2017-12-28 Nanma Manufacturing Co., Ltd. Systems and methods for a male massage apparatus
JP6938863B2 (en) 2016-06-28 2021-09-22 カシオ計算機株式会社 Drawing device
US20180012359A1 (en) * 2016-07-06 2018-01-11 Marinko Venci Sarunic Systems and Methods for Automated Image Classification and Segmentation
US11403751B2 (en) 2016-08-22 2022-08-02 Iris International, Inc. System and method of classification of biological particles
CN106803247B (en) 2016-12-13 2021-01-22 上海交通大学 Microangioma image identification method based on multistage screening convolutional neural network
US10485309B1 (en) 2016-12-16 2019-11-26 Mark Bonner Finger mountable implement
US20180211380A1 (en) * 2017-01-25 2018-07-26 Athelas Inc. Classifying biological samples using automated image analysis
EP3602065A4 (en) 2017-03-20 2020-12-23 Spectral Platforms, Inc. SPECTROSCOPIC METHODS OF DETECTION AND CHARACTERIZATION OF MICROORGANISMS
CN107115099A (en) 2017-03-29 2017-09-01 广州医软智能科技有限公司 A kind of microcirculation of nail rugae imaging device
EP4292520A3 (en) 2017-10-16 2024-07-10 Massachusetts Institute of Technology Systems, devices and methods for non-invasive hematological measurements
US11690540B2 (en) 2019-01-25 2023-07-04 The General Hospital Corporation Systems, methods, and apparatus for differential phase contrast microscopy by transobjective differential EPI-detection of forward scattered light
CN116211296A (en) 2019-07-24 2023-06-06 麻省理工学院 Finger Inserts for Nailfold Imaging Devices
JP7565493B2 (en) 2020-05-28 2024-10-11 レウコ・ラボズ・インコーポレイテッド Method for detecting white blood cells and/or white blood cell subtypes from non-invasive capillary videos and method for determining red blood cell concentration from non-invasive capillary videos - Patents.com
CN117999026A (en) 2021-08-02 2024-05-07 露科实验室股份有限公司 Automated system and method for acquiring images of one or more capillaries in a capillary bed

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120089031A1 (en) * 2003-10-03 2012-04-12 Can Ince Systems and methods for sidesstream dark field imaging
WO2016086023A1 (en) * 2014-11-24 2016-06-02 Massachusetts Institute Of Technology Systems, apparatus, and methods for analyzing blood cell dynamics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BEZEMER R ET AL: "Validation of near-infrared laser speckle imaging for assessing microvascular (re)perfusion", MICROVASCULAR RESEARCH, ACADEMIC PRESS, US, vol. 79, no. 2, 1 March 2010 (2010-03-01), pages 139 - 143, XP026916483, ISSN: 0026-2862, [retrieved on 20100115], DOI: 10.1016/J.MVR.2010.01.004 *
HOWLADER ET AL: "Correlation of severity of chronic venous disease with capillary morphology assessed by capillary microscopy", JOURNAL OF VASCULAR SURGERY, ELSEVIER, AMSTERDAM, NL, vol. 43, no. 3, 1 March 2006 (2006-03-01), pages 563 - 569, XP005314953, ISSN: 0741-5214, DOI: 10.1016/J.JVS.2005.10.077 *

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